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Cancer Cytopathology

Cover image for Cancer Cytopathology

25 August 1998

Volume 84, Issue 4

Pages 193–267

Currently known as: Cancer Cytopathology

  1. Editorials

    1. Top of page
    2. Editorials
    3. Original Articles
    1. Counterpoint

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      Implementing liquid-based gynecologic cytology : Balancing marketing, financial, and scientific issues (pages 193–196)

      R. Marshall Austin

      Article first published online: 10 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980825)84:4<193::AID-CNCR1>3.0.CO;2-O

      Liquid-based gynecologic cytology is being implemented in U.S. laboratories within a complex business, marketing, and scientific environment. Although increased detection of squamous intraepithelial lesions appears promising in early direct-to-vial studies, further risk management experience is needed with the new technology, particularly with regard to the detection of clinically significant endocervical glandular lesions and adequacy criteria.

      See also pages 202-7.

    2. You have free access to this content
      Fine-needle aspiration biopsy of nonpalpable breast lesions : Challenges and promises (pages 197–199)

      Shahla Masood

      Article first published online: 10 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980825)84:4<197::AID-CNCR2>3.0.CO;2-K

      Fine-needle aspiration biopsy remains an effective means of sampling of nonpalpable breast lesions. The continuity of the fine-needle aspiration biopsy procedure requires the participation of the cytopathologist as an active member of a multidisciplinary team.

      See also pages 226-30.

    3. You have free access to this content
      Squamous atypia in the atrophic cervical vaginal smear : A plea for a more painstaking old style look versus a new look at the old problem (pages 200–201)

      Gabriele Medley and Valerie M. Surtees

      Article first published online: 10 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980825)84:4<200::AID-CNCR3>3.0.CO;2-Q

      If the problem of determining the significance of squamous atypia in the atrophic cervical vaginal smear is to be resolved, it will require the same painstaking observation, recording, and analysis of reproducible cytological criteria that the pioneers in cytology undertook when they established this discipline as a credible one in the spectrum of pathologic testing. This is a necessary prerequisite if cytology is to maintain its position as a cost-effective predictor of significant cervical abnormality in this era of limited health dollars.

      See also pages 218-25.

    4. General Topic

      Contemporary Issue
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      The promise and risk of a new technology : The Lehigh Valley Hospital's experience with liquid-based cervical cytology (pages 202–207)

      William B. Dupree, Harry Z. Suprun, David G. Beckwith, John J. Shane and Vincent Lucente

      Article first published online: 10 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980825)84:4<202::AID-CNCR4>3.0.CO;2-O

      Preliminary experience at Lehigh Valley Hospital suggests that the promise of liquid-based cervical cytology preparation not only improves sensitivity of the cytology test but also greatly enhances the overall quality of the cervicovaginal cytology service. Although the promise appears to be real, cautious optimism is indicated. In the future, more liquid-based cervicovaginal tests coupled with outcome studies will help in the evaluation of whether liquid-based systems truly allow better determination of both diagnosis and prognosis.

      See also pages 193-6.

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      The "Inconclusive-Possible high grade epithelial abnormality" category in papanicolaou smear reporting (pages 208–217)

      Meike Schoolland, Gregory F. Sterrett, Simon A. S. Knowles, Kenneth M. Mitchell and Jennifer J. Kurinczuk

      Article first published online: 10 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980825)84:4<208::AID-CNCR5>3.0.CO;2-I

      The category "possible high grade epithelial abnormality" is useful in Papanicolaou smear reporting. In this study it was not overused and provided a high yield of high grade lesions on biopsy follow-up. Accepting uncertainty in the diagnosis of some high grade lesions reduces their likelihood of being classified incorrectly as reactive changes, ignored because of poor cell preservation, or lost in the larger group of classifications such as atypical cells of undetermined significance, borderline nuclear abnormality, or nonspecific minor changes.

  2. Original Articles

    1. Top of page
    2. Editorials
    3. Original Articles
    1. General Topic

      Gynecologic Cytopathology
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      Squamous atypia in the atrophic cervical vaginal smear : A new look at an old problem (pages 218–225)

      Andrea Abati, William Jaffurs and Anna Maria Wilder

      Article first published online: 10 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980825)84:4<218::AID-CNCR6>3.0.CO;2-I

      Nuclear enlargement alone in squamous cells of an atrophic cervical vaginal smear does not warrant a diagnosis of atypical squamous cells of undetermined significance. Nuclear hyperchromasia and irregular nuclear contours remain the most reliable cellular characteristics for diagnosing squamous intraepithelial lesions in atrophic cervical vaginal smears.

      See also pages 200-1.

    2. Fine-Needle Aspiration
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      Stereotaxic aspiration biopsy in the evaluation of mammographically detected clustered microcalcification (pages 226–230)

      Joan Cangiarella, Cecilia L. Mercado, W. Fraser Symmans, Gillian M. Newstead, Hildegard K. Toth and Jerry Waisman

      Article first published online: 10 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980825)84:4<226::AID-CNCR7>3.0.CO;2-K

      Stereotaxic fine-needle aspiration biopsy is a cost-effective and reliable method of evaluating radiologic mammary microcalcification of indeterminate significance.

      See also pages 197-9.

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      Mucoepidermoid carcinoma ex Pleomorphic adenoma : Nonspecific preoperative cytologic findings in six cases (pages 231–234)

      Jerzy Klijanienko, Adel K. El-Naggar, Vincent Servois, Joseph Rodriguez, Pierre Validire and Philippe Vielh

      Article first published online: 10 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980825)84:4<231::AID-CNCR8>3.0.CO;2-P

      In cases of mucoepidermoid carcinoma ex pleomorphic adenoma, cytology slides usually show nonspecific features of high grade carcinoma.

    4. You have full text access to this OnlineOpen article
      Fine-needle aspiration of the macrofollicular and microfollicular subtypes of the follicular variant of papillary carcinoma of the thyroid (pages 235–244)

      Clara E. Mesonero, Julie E. Jugle, David C. Wilbur and Ritu Nayar

      Article first published online: 10 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980825)84:4<235::AID-CNCR9>3.0.CO;2-L

      The pure or predominantly microfollicular and macrofollicular subtypes of the follicular variant of papillary carcinoma of the thyroid can be reliably diagnosed on fine-needle aspirates by using a combination of Papanicolaou and Giemsa-type stains and applying consistent nuclear criteria.

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      Rhabdomyosarcoma presenting as a parotid gland mass in pediatric patients : Fine-needle aspiration biopsy findings (pages 245–251)

      Diva R. Salomão, June D. Sigman, Ellen Greenebaum and Michael B. Cohen

      Article first published online: 10 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980825)84:4<245::AID-CNCR10>3.0.CO;2-S

      This article describes the occurrence of rhabdomyosarcoma presenting as a parotid mass.

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      Utilization of fine-needle aspiration cytology and flow cytometry in the diagnosis and subclassification of primary and recurrent lymphoma (pages 252–261)

      Nancy A. Young, Tahseen I. Al-Saleem, Hormoz Ehya and Mitchell R. Smith

      Article first published online: 10 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980825)84:4<252::AID-CNCR11>3.0.CO;2-R

      The experience at a cancer referral center in the diagnosis and subclassification of primary and recurrent lymphoma by fine-needle aspiration cytology combined with immunophenotyping by flow cytometry is discussed.

    7. Molecular Diagnostics
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      Polymerase chain reaction-based detection of clonality as a non-morphologic diagnostic tool for fine-needle aspiration of the breast (pages 262–267)

      Jessica L. Magda, Brett A. Minger and David L. Rimm

      Article first published online: 10 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980825)84:4<262::AID-CNCR12>3.0.CO;2-Q

      Clonality, as assessed by gene rearrangement, has become a useful adjunctive test in hematopathology, but has not yet been proven in non-hematologic malignancies. This pilot work describes use of the human androgen receptor locus to assess clonality in fine-needle aspiration of the breast and found that although all malignancies are monoclonal, some nonmalignant proliferative lesions also appear to be clonal by this assay.

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