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Cancer

Cover image for Cancer

1 October 1998

Volume 83, Issue 7

Pages 1275–1470

  1. Cancer—50 Years Later

    1. Top of page
    2. Cancer—50 Years Later
    3. Editorials
    4. Commentaries
    5. Original Articles
    6. Correspondence
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      Cancer epidemiology 50 years later (pages 1275–1277)

      Curtis J. Mettlin

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981001)83:7<1275::AID-CNCR1>3.0.CO;2-I

      A review of observations on cancer epidemiology from the inaugural volume of Cancer reveals insights that continue to be valid and changes that demonstrate the progress that has been made.

  2. Editorials

    1. Top of page
    2. Cancer—50 Years Later
    3. Editorials
    4. Commentaries
    5. Original Articles
    6. Correspondence
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      Can cancer risks be Altered by changing nutritional traditions? (pages 1278–1281)

      John H. Weisburger

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981001)83:7<1278::AID-CNCR2>3.0.CO;2-F

      Many chronic diseases, including cardiovascular diseases and cancer, stem from the prevailing lifestyle in any part of the world. Approximately 30% of such diseases are associated with tobacco use and approximately 60% with nutritional traditions and habits. Once these causative factors have been established through careful research, recommendations for prevention can be made. This is important for the individuals concerned, their families, their health management teams and insurance carriers, and their nation. Primary prevention is the best means of disease control.

      See also pages 1425-32.

  3. Commentaries

    1. Top of page
    2. Cancer—50 Years Later
    3. Editorials
    4. Commentaries
    5. Original Articles
    6. Correspondence
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      Cancer surveillance in the U.S. : Can we have a national system? (pages 1282–1291)

      Judith Swan, Phyllis Wingo, Rosemarie Clive, Dee West, Daniel Miller, Carol Hutchison, Edward J. Sondik and Brenda K. Edwards

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981001)83:7<1282::AID-CNCR3>3.0.CO;2-L

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      This report profiles cancer surveillance efforts in the U.S. and describes the National Coordinating Council for Cancer Surveillance, which was organized in 1995 to facilitate a collaborative approach among the organizations involved.

  4. Original Articles

    1. Top of page
    2. Cancer—50 Years Later
    3. Editorials
    4. Commentaries
    5. Original Articles
    6. Correspondence
    1. Anatomic Site

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      Salivary gland malignant myoepithelioma : A clinicopathologic and immunohistochemical study of ten cases (pages 1292–1299)

      Toshitaka Nagao, Isamu Sugano, Yasuo Ishida, Yasuo Tajima, Osamu Matsuzaki, Akiyoshi Konno, Yoichiro Kondo and Koichi Nagao

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981001)83:7<1292::AID-CNCR4>3.0.CO;2-L

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      Malignant myoepithelioma is a rare salivary gland tumor showing clinicopathologic diversity and presenting with various stages of myoepithelial differentiation. Histologic aggressiveness, marked cellular pleomorphism, p53 expression, and high cell proliferative activity are correlated with a poor clinical outcome.

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      Immunohistochemical evaluation of thymidylate synthase in gastric carcinoma using a new polyclonal antibody : The clinical role of thymidylate synthase as a prognostic indicator and its therapeutic usefulness (pages 1300–1306)

      Tetsuya Kuniyasu, Takeshi Nakamura, Yoshiki Tabuchi and Yoshikazu Kuroda

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981001)83:7<1300::AID-CNCR5>3.0.CO;2-M

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      Thymidylate synthase (TS) in gastric carcinoma was studied immunohistochemically using a new polyclonal antibody. From the results of univariate and multivariate analyses, it was concluded that the immunohistochemical evaluation of TS is useful in determining the prognosis of patients with gastric carcinoma.

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      Multifocal occurrence of gastric carcinoma in patients with a family history of gastric carcinoma (pages 1307–1311)

      Masaru Morita, Hiroyuki Kuwano, Hideo Baba, Akinobu Taketomi, Shunji Kohnoe, Hirotsugu Tomoda, Kohshi Araki, Hiroshi Saeki, Kaoru Kitamura and Keizo Sugimachi

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981001)83:7<1307::AID-CNCR6>3.0.CO;2-F

      In patients with gastric carcinoma, a family history of gastric carcinoma is a risk factor for the multifocal occurrence of their gastric carcinoma.

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      A clinicopathologic study of mucinous gastric carcinoma including multivariate analysis (pages 1312–1318)

      Chun-Ying Wu, Hong-Zen Yeh, Rocky Tai-Ping Shih and Gran-Hum Chen

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981001)83:7<1312::AID-CNCR7>3.0.CO;2-K

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      The mucinous gastric carcinoma (MGC) patients in this study were found to have biologically more aggressive disease and a lower 5-year survival rate than patients with nonmucinous gastric carcinoma (NGC). This pessimistic outcome was observed in both the moderately differentiated and the poorly differentiated MGC cases. However, multivariate analysis demonstrated that the poor prognosis of MGC patients was correlated with more advanced stage at diagnosis and frequent serosal invasion, not with the mucinous histology itself.

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      Rectal epithelial proliferation in persons with or without a history of adenoma and its association with diet and lifestyle habits (pages 1319–1327)

      Paul Rozen, Flora Lubin, Naomi Papo and Gershom Zajicek

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981001)83:7<1319::AID-CNCR8>3.0.CO;2-D

      In 223 screenees, rectal epithelial proliferation was not increased in 132 screenees who previously had adenomas compared with 91 adenoma free individuals. Proliferation levels appeared to be associated with gender and age, as well as diet and other lifestyle habits; therefore these factors should be considered when using proliferation measurements as a biomarker of risk for neoplasia and response to chemoprevention.

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      Adenocarcinoma of the pancreas : Detection of occult metastases in regional lymph nodes by a polymerase chain reaction-based assay (pages 1328–1334)

      Michael J. Demeure, Kara M. Doffek, Richard A. Komorowski and Stuart D. Wilson

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981001)83:7<1328::AID-CNCR9>3.0.CO;2-E

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      Stage I pancreatic adenocarcinoma is associated with poor survival rates despite the appearance of localized lymph node negative tumors. With a sensitive molecular polymerase chain reaction/restriction fragment length polymorphism assay for K-ras mutations, metastases were identified in the lymph nodes of 16 of 22 patients with this disease.

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      Bombesin/gastrin-releasing peptide antagonists RC-3095 and RC-3940-II inhibit tumor growth and decrease the levels and mRNA expression of epidermal growth factor receptors in H-69 small cell lung carcinoma (pages 1335–1343)

      Miklós Koppán, Gábor Halmos, José M. Arencibia, Najib Lamharzi and Andrew V. Schally

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981001)83:7<1335::AID-CNCR10>3.0.CO;2-5

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      Bombesin antagonists RC-3095 and RC-3940-II effectively inhibited growth of H-69 small cell lung carcinoma in nude mice and reduced the level and mRNA expression of epidermal growth factor receptors on tumor membranes. These peptide analogs should be considered for the treatment of small cell lung carcinoma.

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      Remission induction therapy of untreated acute myeloid leukemia using a non-cytarabine-containing regimen of idarubicin, etoposide, and carboplatin (pages 1344–1354)

      Eric J. Bow, Gilles Gallant, Gaynor J. Williams, Donna Woloschuk, Tsiporah B. Shore, Morel Rubinger and Brent A. Schacter

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981001)83:7<1344::AID-CNCR11>3.0.CO;2-4

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      Remission induction therapy with idarubicin, etoposide, and carboplatin was studied in adults with untreated acute myeloid leukemia. Although 67% of subjects achieved remission despite a high incidence of unfavorable karyotypes, mucosal toxicity limited the tolerability of this regimen.

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      Tumor-associated antigen TA-90 immune complex assay predicts subclinical metastasis and survival for patients with early stage melanoma (pages 1355–1361)

      Mark C. Kelley, Ralph C. Jones, Rishab K. Gupta, Reynold Yee, Stacey Stern, Leslie Wanek and Donald L. Morton

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981001)83:7<1355::AID-CNCR12>3.0.CO;2-3

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      An antigen specific assay for TA-90, a glycoprotein tumor marker, accurately predicted subclinical metastatic disease in patients with clinical Stage I melanoma. A multivariate analysis with standard prognostic factors demonstrated that a patient's TA-90 status was significantly correlated with disease free and overall survival.

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      Complications of axillary lymph node dissection for carcinoma of the breast : A report based on a patient survey (pages 1362–1368)

      Marc A. Warmuth, Gray Bowen, Leonard R. Prosnitz, Luis Chu, Gloria Broadwater, Bercedis Peterson, George Leight and Eric P. Winer

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981001)83:7<1362::AID-CNCR13>3.0.CO;2-2

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      Mild symptoms, especially pain and numbness, are common 2-5 years following axillary lymph node dissection.

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      A proposed glossary of terminology related to the surgical treatment of vulvar carcinoma (pages 1369–1375)

      Leonardo Micheletti, Mario Preti, Paolo Zola, Maria Clara Zanotto Valentino, Carlo Bocci and Fabrizio Bogliatto

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981001)83:7<1369::AID-CNCR14>3.0.CO;2-2

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      A glossary of terminology related to the surgical treatment of vulvar carcinoma is proposed to allow better understanding and exchange of experiences among oncologists.

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      Expression of p150 in cervical neoplasia and its potential value in predicting survival (pages 1376–1383)

      Athanassios Dellas, Joachim Torhorst, Felix Bachmann, Rahel Bänziger, Elisabeth Schultheiss and Max M. Burger

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981001)83:7<1376::AID-CNCR15>3.0.CO;2-1

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      A novel cloned p150 protein in cervical neoplasia is associated with disease progression and prognosis.

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      Angiogenesis in adenocarcinoma of the uterine cervix (pages 1384–1390)

      Tsunehisa Kaku, Toshio Hirakawa, Toshiharu Kamura, Satoshi Amada, Naoko Kinukawa, Hiroaki Kobayashi, Kunihiro Sakai, Kazuya Ariyoshi, Kenzo Sonoda and Hitoo Nakano

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981001)83:7<1384::AID-CNCR16>3.0.CO;2-0

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      In the current study cervical adenocarcinoma with a high microvessel count demonstrated a worse prognosis. Early adenocarcinoma was found to be angiogenic and adenoma malignum exhibited a high microvessel count.

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      Endocrine tumors of the cervix : Morphologic assessment, expression of human papillomavirus, and evaluation for loss of heterozygosity on 1p, 3p, 11q, and 17p (pages 1391–1400)

      Ciaran Mannion, Won-Sang Park, Yan Gao Man, Zhengping Zhuang, Jorge Albores-Saavedra and Fattaneh A. Tavassoli

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981001)83:7<1391::AID-CNCR17>3.0.CO;2-#

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      Endocrine tumors of the cervix are highly aggressive, can be subdivided into definable histopathologic categories, and are associated strongly with high risk types of human papillomavirus. Although loss of heterozygosity (LOH) at multiple 3p loci frequently is detected in these lesions, LOH at 17p(TP53 locus) is relatively uncommon and suggests that p53 mutations may not be important in the development of these neoplasms.

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      Expression of ras, c-myc, and p53 proteins in cervical intraepithelial neoplasia (pages 1401–1408)

      Betty L. Slagle, Raymond H. Kaufman, William C. Reeves and Joseph P. Icenogle

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981001)83:7<1401::AID-CNCR18>3.0.CO;2-8

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      Immunohistochemical detection of oncoproteins p21ras and p62myc and of tumor suppressor protein p53 in 395 cervical biopsy specimens revealed grade common and grade specific expression patterns.

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      Postchemotherapy residual masses in germ cell tumor patients : Content, clinical features, and prognosis (pages 1409–1419)

      Sally P. Stenning, M. Constance Parkinson, Cyril Fisher, Graham M. Mead, Patricia A. Cook, Sophie D. Fossa, Alan Horwich, William G. Jones, Edward S. Newlands, R. Timothy Oliver, A. Elizabeth Stenwig and Peter M. Wilkinson

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981001)83:7<1409::AID-CNCR19>3.0.CO;2-8

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      Progression free survival of germ cell tumor patients with residual masses after chemotherapy can be predicted by the completeness of excision and the presence of malignant germ cell elements. The presence of malignant germ cell elements, even those completely resected, confers a relatively poor prognosis.

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      Ovarian transposition by laparoscopy before radiotherapy in the treatment of hodgkin's disease (pages 1420–1424)

      Jean-Marc Classe, Marc Mahé, Philippe Moreau, Marie-Josée Rapp, Hervé Maisonneuve, Annick Lemevel, Sylvain Bourdin, Jean-Luc Harousseau and Jean-Claude Cuillière

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981001)83:7<1420::AID-CNCR20>3.0.CO;2-5

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      Ovarian transposition, a procedure that can improve the posttherapeutic quality of life for young women treated with abdominopelvic radiotherapy for advanced Hodgkin's disease, can be performed effectively by laparoscopy.

    18. General Topic

      Cancer Prevention and Diet
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      Progress in improving diet to reduce cancer risk (pages 1425–1432)

      Susan M. Krebs-Smith

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981001)83:7<1425::AID-CNCR21>3.0.CO;2-5

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      Americans have made modest but important improvements in their diets in recent years and may meet the "Healthy People 2000" dietary objectives aimed at decreasing cancer risk. These trends are consistent with recent improvements in mortality rates for those patients with cancer sites that have demonstrated the strongest associations with diet: the colon/rectum, prostate, and breast.

      See also pages 1278-81.

    19. Chemotherapy: Toxicity Prevention
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      Oral glutamine reduces the duration and severity of stomatitis after cytotoxic cancer chemotherapy (pages 1433–1439)

      Peter M. Anderson, Georgene Schroeder and Keith M. Skubitz

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981001)83:7<1433::AID-CNCR22>3.0.CO;2-4

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      Glutamine suspension significantly reduces the duration and severity of mucositis associated with chemotherapy. This simple adjunct may improve the quality of life of patients receiving chemotherapy who have had mouth sores associated with chemotherapy.

    20. Pediatric Oncology
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      Epidemiology of osteosarcoma and Ewing's sarcoma in childhood : A study of 305 cases by the Children's Cancer Group (pages 1440–1448)

      Jonathan D. Buckley, Thomas W. Pendergrass, Constance M. Buckley, Douglas J. Pritchard, Mark E. Nesbit, Arthur J. Provisor and Leslie L. Robison

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981001)83:7<1440::AID-CNCR23>3.0.CO;2-3

      Results from a comprehensive case-control study of children with osteosarcoma and Ewing's sarcoma are presented. Although a number of differences were observed with respect to growth and development prior to diagnosis, there were no consistent patterns in these differences, and the study did not point to any other factors that might contribute to the risk of developing these bone tumors.

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      A Phase I study of granulocyte-macrophage-colony stimulating factor/interleukin-3 fusion protein (PIXY321) following ifosfamide, carboplatin, and etoposide therapy for children with recurrent or refractory solid tumors : A report of the Children's Cancer Group (pages 1449–1460)

      Mitchell S. Cairo, Mark D. Krailo, Joel A. Weinthal, Rita Secola, Sharon Bergeron, Carmella van de Ven, Bruce R. Blazar, Leslie Garrison and Gregory H. Reaman

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981001)83:7<1449::AID-CNCR24>3.0.CO;2-3

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      PIXY321 was well tolerated by the children in this trial, and its maximum tolerated dose has yet to be reached. PIXY321 administration following myelosuppressive chemotherapy with ifosfamide, carboplatin, and etoposide appears to enhance both in vitro and in vivo hematologic recovery.

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      Prenatal exposure to metronidazole and risk of childhood cancer : A retrospective cohort study of children younger than 5 years (pages 1461–1468)

      Purushottam B. Thapa, James A. Whitlock, Kelly G. Brockman Worrell, Patricia Gideon, Edward F. Mitchel Jr., Paula Roberson, Ray Pais and Wayne A. Ray

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981001)83:7<1461::AID-CNCR25>3.0.CO;2-1

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      The authors evaluated the role of in utero exposure to metronidazole and the risk of subsequent cancer in a retrospective cohort study of 328,846 children younger than 5 years. They concluded that there was no increase in risk for all cancers associated with in utero exposure to metronidazole, but suggested that the observed increased risk for neuroblastomas, although not significant, needs further evaluation.

  5. Correspondence

    1. Top of page
    2. Cancer—50 Years Later
    3. Editorials
    4. Commentaries
    5. Original Articles
    6. Correspondence
    1. You have free access to this content
    2. You have free access to this content
      Author reply (pages 1469–1470)

      Yoshiaki Sumiyoshi, Takayuki Shirakusa, Yuichi Yamashita, Takafumi Maekawa, Teru Hidoshima, Katsunobu Kawahara and Masahiro Kikuchi

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981001)83:7<1470::AID-CNCR27>3.0.CO;2-0

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