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Cancer

Cover image for Cancer

15 November 1998

Volume 83, Issue 10

Pages 2049–2240

  1. Original Articles

    1. Top of page
    2. Original Articles
    3. Communications
    4. Errata
    1. Anatomic Site

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      Changing patterns in the incidence of esophageal and gastric carcinoma in the United States (pages 2049–2053)

      Susan S. Devesa, William J. Blot and Joseph F. Fraumeni Jr.

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981115)83:10<2049::AID-CNCR1>3.0.CO;2-2

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      Previously reported increases of esophageal adenocarcinoma are continuing, most notably among white males. Cigarette smoking may contribute to the trend through an early stage carcinogenic effect, along with obesity, which may increase intraabdominal pressure and predispose to gastroesophageal reflux disease.

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      OK-432 and 5-fluorouracil, doxorubicin, and mitomycin C (FAM-P) versus FAM chemotherapy in patients with curatively resected gastric carcinoma : A randomized Phase III trial (pages 2054–2059)

      Si-Young Kim, Ho C. Park, Choong Yoon, Hwi J. Yoon, Yong M. Choi and Kyung S. Cho

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981115)83:10<2054::AID-CNCR2>3.0.CO;2-1

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      Gastric carcinoma is the leading cause of cancer death in Korea. Different adjuvant chemotherapy regimens have been proposed and tested in an effort to improve patient outcome after surgical resection. The authors report the effect of the addition of OK-432, which may be an active well tolerated agent, to a combined chemotherapy regimen comprised of 5-fluorouracil, doxorubicin, mitomycin C, and the intradermal administration of OK-432 on the survival of patients with gastric carcinoma who previously underwent curative resection.

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      Telomerase activity in gastrointestinal stromal tumors (pages 2060–2066)

      Shinji Sakurai, Masashi Fukayama, Yasuharu Kaizaki, Ken Saito, Kyotaro Kanazawa, Masatsugu Kitamura, Yoshiaki Iwasaki, Tsunekazu Hishima, Yukiko Hayashi and Morio Koike

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981115)83:10<2060::AID-CNCR3>3.0.CO;2-#

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      In this study of gastrointestinal stromal tumors, reactivation of telomerase, which was observed in high grade tumors of larger size with higher proliferating activity and p53 expression, was correlated inversely with poor patient prognosis.

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      A morphometric study of neovascularization in colorectal carcinoma (pages 2067–2075)

      Petros M. Pavlopoulos, Anastasia E. Konstantinidou, Emmanuel Agapitos, Nikolaos Kavantzas, Polyxeni Nikolopoulou and Panagiotis Davaris

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981115)83:10<2067::AID-CNCR4>3.0.CO;2-Q

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      Microvessel morphometry can provide more significant prognostic information in patients with colorectal carcinoma compared with microvessel density.

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      The fucosylation index of α-fetoprotein as a possible prognostic indicator for patients with hepatocellular carcinoma (pages 2076–2082)

      Yutaka Aoyagi, Osamu Isokawa, Takeshi Suda, Masashi Watanabe, Yasufumi Suzuki and Hitoshi Asakura

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981115)83:10<2076::AID-CNCR5>3.0.CO;2-L

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      The measurement of the fucosylation index of α-fetoprotein from sera before the initiation of treatment serves as a new prognostic factor and may improve prognostic estimates and appraisal of therapeutic outcomes for patients with hepatocellular carcinoma.

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      First-line treatment of advanced nonsmall cell lung carcinoma with docetaxel and vinorelbine (pages 2083–2090)

      Charalambos Kourousis, Nicos Androulakis, Stelios Kakolyris, John Souglakos, George Maltezakis, George Metaxaris, George Chalkiadakis, George Samonis, John Vlachonikolis and Vassilis Georgoulias

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981115)83:10<2083::AID-CNCR6>3.0.CO;2-I

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      The tolerance and efficacy of a combination of vinorelbine and docetaxel was studied in 46 chemotherapy-naive patients with nonoperable nonsmall cell lung carcinoma. Four complete and 11 partial responses were documented; the median overall survival was 5 months. Despite its efficacy, this regimen has relatively high hematologic toxicity and cannot be recommended for general use.

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      High levels of hepatocyte growth factor/scatter factor in diffuse-type bronchioloalveolar cell carcinoma (pages 2091–2098)

      Jun-ichi Yamashita, Michio Ogawa, Shogo Nakano, Kazutoshi Okabe, Michio Abe, Akinori Iwasaki, Motohisa Kuwahara, Yasuteru Yoshinaga and Takayuki Shirakusa

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981115)83:10<2091::AID-CNCR7>3.0.CO;2-E

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      Diffuse-type bronchioloalveolar cell carcinoma (BAC) expresses considerably more hepatocyte growth factor/scatter factor than solitary-type BAC or other types of nonsmall cell lung carcinoma, as measured by an enzyme-linked immunosorbent assay.

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      Intrapleural administration of interleukin-2 for the treatment of patients with malignant pleural mesothelioma : A Phase II study (pages 2099–2104)

      Philippe Astoul, Diane Picat-Joossen, Jean-Regis Viallat and Christian Boutin

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981115)83:10<2099::AID-CNCR8>3.0.CO;2-3

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      Intrapleural interleukin-2 for the treatment of patients with malignant pleural mesothelioma is well tolerated, efficient, and results in prolonged survival.

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      Primary chondrosarcoma of long bones and limb girdles (pages 2105–2119)

      Johannes Björnsson, Richard A. McLeod, K. Krishnan Unni, Duane M. Ilstrup and Douglas J. Pritchard

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981115)83:10<2105::AID-CNCR9>3.0.CO;2-U

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      A clinicopathologic study of 344 patients with primary chondrosarcoma determined that chondrosarcoma is primarily a local disease and that histologic tumor grade is a highly significant predictor of biologic behavior.

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      Clinical correlates of the presence of the asp816Val c-kit mutation in the peripheral blood mononuclear cells of patients with mastocytosis (pages 2120–2129)

      Alexandra S. Worobec, Tekli Semere, Hiroshi Nagata and Dean D. Metcalfe

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981115)83:10<2120::AID-CNCR10>3.0.CO;2-C

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      The presence of the Asp816Val mutation in the catalytic domain of the c-kit receptor in peripheral blood mononuclear cells (PBMCs) appears to be associated with identifiable clinical patterns of mastocytosis with differing prognoses. Determination of the presence or absence of this mutation in PBMCs of mastocytosis patients offers a useful adjunct in determining the extent of workup and assigning prognosis in this complex and heterogeneous disease.

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      Type of mastectomy and quality of life for long term breast carcinoma survivors (pages 2130–2138)

      Michel Dorval, Elizabeth Maunsell, Luc Deschênes and Jacques Brisson

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981115)83:10<2130::AID-CNCR11>3.0.CO;2-8

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      From a public health perspective, the findings of this study suggest that more frequent performance of partial mastectomy may lessen the negative effect of breast carcinoma on younger survivors' quality of life. Nevertheless, total mastectomy may conceivably be the appropriate initial treatment for some women who truly choose it.

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      Ductal carcinoma in situ (DCIS) in the male breast : A morphologic study of 84 cases of pure DCIS and 30 cases of DCIS associated with invasive carcinoma-a preliminary report (pages 2139–2149)

      Anton P. Hittmair, Ruth A. Lininger and Fattaneh A. Tavassoli

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981115)83:10<2139::AID-CNCR12>3.0.CO;2-F

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      Ductal carcinoma in situ (DCIS) in the male breast most frequently presents as a low grade papillary retroareolar tumor; high grade (comedo) DCIS in pure in situ lesions is quite rare, in contrast to DCIS associated with invasive carcinoma.

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      Visual inspection of the uterine cervix after the application of acetic acid in the detection of cervical carcinoma and its precursors (pages 2150–2156)

      Rengaswamy Sankaranarayanan, Remani Wesley, Thara Somanathan, Namrata Dhakad, B. Shyamalakumary, N. Sreedevi Amma, D. Maxwell Parkin and Madhavan Krishnan Nair

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981115)83:10<2150::AID-CNCR13>3.0.CO;2-0

      Visual inspection of the uterine cervix after the application of 3-4% acetic acid (VIA) to detect distinct acetowhite areas, used as a screening test for cervical neoplasia, performed very similarly to cervical cytology in detecting moderate dysplasia or more advanced lesions in the setting in which this study was conducted. VIA merits further evaluation as a primary cervical carcinoma screening tool in low-resource settings.

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      Serous borderline tumors of the ovary with noninvasive peritoneal implants (pages 2157–2163)

      David M. Gershenson, Elvio G. Silva, Guillermo Tortolero-Luna, Charles Levenback, Mitchell Morris and Carmen Tornos

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981115)83:10<2157::AID-CNCR14>3.0.CO;2-D

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      Approximately 30% of patients who have serous borderline tumors of the ovary with noninvasive peritoneal implants will develop progressive or recurrent tumors, most commonly serous carcinomas.

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      Predictors of survival for prostate carcinoma patients treated with salvage radical prostatectomy after radiation therapy (pages 2164–2171)

      Liang Cheng, Thomas J. Sebo, Jeff Slezak, Thomas M. Pisansky, Erik J. Bergstralh, Roxann M. Neumann, Kenneth A. Iczkowski, Horst Zincke and David G. Bostwick

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981115)83:10<2164::AID-CNCR15>3.0.CO;2-I

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      Long term cancer control was achieved when salvage prostatectomy was performed on selected patients with postirradiation local recurrence. Radical prostatectomy Gleason score and DNA ploidy were independent predictors of distant metastasis free survival and cancer specific survival for patients treated with this approach. Gleason score is still the gold standard for estimating the biologic aggressiveness of prostate carcinoma after radiation therapy.

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      Analyzing outcome-based staging for clinically localized adenocarcinoma of the prostate (pages 2172–2180)

      Anthony V. D'Amico, April Desjardin, Ming-Hui Chen, Steve Paik, Delray Schultz, Andrew A. Renshaw, Kevin R. Loughlin and Jerome P. Richie

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981115)83:10<2172::AID-CNCR16>3.0.CO;2-K

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      A proposed clinical staging system based on the prostate specific antigen (PSA) and the calculated volume of prostate carcinoma provided a clinically useful estimate of both postoperative and postradiation PSA failure free survival in patients with American Joint Committee on Cancer clinical T1,2 disease.

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      Brain metastases as the only manifestation of an undetected primary tumor (pages 2181–2184)

      Linh N. Nguyen, Moshe H. Maor and Mary Jane Oswald

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981115)83:10<2181::AID-CNCR17>3.0.CO;2-J

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      Treatment to the brain is effective in controlling intracranial metastases from undetected primary tumors; aggressive treatment with gross total resection and radiation is recommended.

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      Genetic and epigenetic alterations of the cyclin-dependent kinase inhibitors p15INK4b and p16INK4a in human thyroid carcinoma cell lines and primary thyroid carcinomas (pages 2185–2193)

      Rossella Elisei, Masaaki Shiohara, H. Phillip Koeffler and James A. Fagin

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981115)83:10<2185::AID-CNCR18>3.0.CO;2-4

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      Mutations of p16INK4a are common in thyroid carcinoma cell lines but rare in primary thyroid neoplasms. However, the p16 gene is subject to methylation in thyroid adenomas and papillary carcinomas, in which the function of this gene may be lost as an epigenetic event.

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      Mitotane associated with etoposide, doxorubicin, and cisplatin in the treatment of advanced adrenocortical carcinoma (pages 2194–2200)

      Alfredo Berruti, Massimo Terzolo, Anna Pia, Alberto Angeli and Luigi Dogliotti

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981115)83:10<2194::AID-CNCR19>3.0.CO;2-3

      Administration of mitotane plus etoposide, doxorubicin, and cisplatin to 28 patients with advanced adrenocortical carcinoma resulted in a 53.4% response rate that lasted 24.4 months. The toxicity was manageable.

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      Evaluation of the newly updated TNM classification of head and neck carcinoma with data from 3247 patients (pages 2201–2207)

      Heinrich Iro and Frank Waldfahrer

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981115)83:10<2201::AID-CNCR20>3.0.CO;2-7

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      The current study investigates the prognostic relevance of the newly updated TNM classification of head and neck tumors with data from a population of 3247 patients with carcinoma of the head and neck. Particular attention is focused on the division of Stage IV tumors into three substages.

    21. General Topic

      Pediatric Oncology
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      Malignant tumors of the kidney, brain, and soft tissues in children and young adults with the tuberous sclerosis complex (pages 2208–2216)

      Tahseen Al-Saleem, Lisa L. Wessner, Bernd W. Scheithauer, Kathleen Patterson, E. Steven Roach, Stephen J. Dreyer, Keita Fujikawa, Johannes Bjornsson, Jay Bernstein and Elizabeth Petri Henske

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981115)83:10<2208::AID-CNCR21>3.0.CO;2-K

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      In this article, the authors report on malignant tumors of the kidney, brain, and soft tissues in six children and young adults with the tuberous sclerosis complex. Three patients had renal cell carcinomas, two had malignant angiomyolipomas, and one had a glioblastoma multiforme.

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      The effects of etoposide on testicular function in boys treated for Hodgkin's disease (pages 2217–2222)

      Lars Gerres, Jürgen H. Brämswig, Werner Schlegel, Heribert Jürgens and Günther Schellong

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981115)83:10<2217::AID-CNCR22>3.0.CO;2-J

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      When two courses of chemotherapy with vincristine, etoposide, prednisone, and doxorubicin are used, testicular function is normal in boys with Ann Arbor Stage I-IIA Hodgkin's disease. Other chemotherapeutic regimens (mechlorethamine, vincristine, procarbazine, prednisone, doxorubicin, bleomycin, vinblastine, and dacarbazine [MOPP]; vincristine, procarbazine, prednisone, and doxorubicin [OPPA]; cyclophosphamide, vincristine, procarbazine, and prednisone [COPP]; and chlorambucil, vinblastine, prednisolone, and procarbazine [ChlVPP]) have a 30-90% risk of severe testicular damage, especially infertility.

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      Trends in childhood cancer mortality as indicators of the quality of medical care in the developed world (pages 2223–2227)

      Carlo La Vecchia, Fabio Levi, Franca Lucchini, Pagona Lagiou, Dimitrios Trichopoulos and Eva Negri

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981115)83:10<2223::AID-CNCR23>3.0.CO;2-R

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      The decline of mortality from childhood cancers has been more pronounced in North America than in other economically developed areas of the world. When disease control depends on technologically advanced medical care, the North American population is in a better position.

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      Precursor lesions of Wilms' tumor in Indian children : A multiinstitutional study (pages 2228–2232)

      Kiran Mishra, Meera Mathur, K. B. Logani, Nandita Kakkar and Anurag Krishna

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981115)83:10<2228::AID-CNCR24>3.0.CO;2-9

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      This article highlights the differences between nephrogenic rests and its associated factors in children with Wilms' tumor reported in India and the West. Its findings suggest a different demographic and genetic basis of origin of the tumor that could have important clinical and therapeutic implications.

  2. Communications

    1. Top of page
    2. Original Articles
    3. Communications
    4. Errata
    1. General Topic

      International Union Against Cancer
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      Workshop on prostate markers (pages 2233–2238)

      Gerald P. Murphy and Alan Partin

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981115)83:10<2233::AID-CNCR25>3.0.CO;2-K

      Clinicians and scientists from Europe and the U. S. recently met to discuss new data regarding relevant markers for prostate carcinoma. These markers are of particular interest because of their potential to improve the diagnosis of early prostate carcinoma and their ability to aid in the prognostic evaluation of all stages of disease. Neuroendocrine cell markers, free prostate specific antigen (PSA), complex PSA (hK2), and prostate specific membrane antigen were evaluated. The results raise significant questions for current and future research.

  3. Errata

    1. Top of page
    2. Original Articles
    3. Communications
    4. Errata
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      Idiopathic giant cell myocarditis after autologous hematopoietic stem cell transplantation and interleukin-2 immunotherapy: a case report (pages 2239–2240)

      CI Truica, CH Hansen, DF Garvin and KR Meehan

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981115)83:10<2239::AID-CNCR26>3.0.CO;2-#

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      A Phase I trial of continuous hyperthermic peritoneal perfusion with tumor necrosis factor and cisplatin in the treatment of peritoneal carcinomatosis (page 2240)

      DL Bartlett, JF Buell, SK Libutti, E Reed, KB Lee, WE Figg, DJ Venzon and HR Alexander

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/1097-0142(19981115)83:10<2240::AID-CNCR27>3.0.CO;2-M

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      Malignant lymphoma in Thailand: changes in the frequency of malignant lymphoma determined from a histopathologic and immunophenotypic analysis of 425 cases at Siriraj Hospital (page 2240)

      S Sukpanichnant, D Sonakul, A Piankijagum, W Wanachiwanawin, G Veerakul and C Mahasandana

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/1097-0142(19981115)83:10<2240::AID-CNCR28>3.0.CO;2-J

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