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Cancer

Cover image for Cancer

1 December 1998

Volume 83, Issue 11

Pages 2243–2423

  1. Cancer—50 Years Later

    1. Top of page
    2. Cancer—50 Years Later
    3. Editorials
    4. Review Articles
    5. Original Articles
    6. Communications
    7. Correspondence
    1. You have free access to this content
      Intraepithelial carcinoma of the cervix : Reflections on half a century of progress (pages 2243–2246)

      Mark E. Sherman and Robert J. Kurman

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981201)83:11<2243::AID-CNCR1>3.0.CO;2-D

      Advances in our understanding of cervical carcinoma epidemiology, biology, and pathology that have been achieved in the last 50 years are briefly summarized.

  2. Editorials

    1. Top of page
    2. Cancer—50 Years Later
    3. Editorials
    4. Review Articles
    5. Original Articles
    6. Communications
    7. Correspondence
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      Cancer mortality among Native Americans (pages 2247–2250)

      Linda Burhansstipanov

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981201)83:11<2247::AID-CNCR2>3.0.CO;2-6

      The article by Cobb and Paisano in this issue of Cancer raises a number of important issues regarding Native American cancer research priorities. These include variations in anatomic cancer sites among Native Americans in different geographic regions, as well as the need for further study of specific risk factors for cancers affecting Native Americans.

      See also pages 2377-83.

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      Breast carcinoma in carriers of BRCA1 or BRCA2 mutations : Implications of proposed distinct histologic phenotypes (pages 2251–2254)

      Kelly-Anne Phillips

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981201)83:11<2251::AID-CNCR3>3.0.CO;2-6

      Emerging evidence for distinct histologic phenotypes for BRCA-associated breast tumors correlates with the concept of different molecular pathogenesis pathways in these tumors compared with sporadic tumors. The clinical value of determination of histologic differences between BRCA-associated and sporadic tumors requires further elucidation.

      See also pages 2335-45.

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      Is chemotherapy beneficial in the treatment of locoregionally advanced nasopharyngeal carcinoma? (pages 2255–2258)

      James R. Wong

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/1097-0142(19981201)83:11<2255::AID-CNCR4>3.0.CO;2-#

      The theoretic basis of neoadjuvant chemotherapy is to enhance locoregional control by tumor debulking or sensitizing the tumor to radiation, and to decrease distant metastasis by treatment of occult micrometastasis. Nasopharyngeal carcinoma, a very chemoresponsive tumor with a high incidence of distant metastasis, should be an excellent head and neck malignancy for neoadjuvant chemotherapy to display its potential. However, whether chemotherapy should be used routinely in the treatment of nasopharyngeal carcinoma is still controversial.

      See also pages 2270-83.

  3. Review Articles

    1. Top of page
    2. Cancer—50 Years Later
    3. Editorials
    4. Review Articles
    5. Original Articles
    6. Communications
    7. Correspondence
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      Current evaluation of the tissue localization and diagnostic utility of prostate specific membrane antigen (pages 2259–2269)

      Gerald P. Murphy, Abdel-Aziz A. Elgamal, Sai L. Su, David G. Bostwick and Eric H. Holmes

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981201)83:11<2259::AID-CNCR5>3.0.CO;2-T

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      Prostate specific membrane antigen is a highly prostate-restricted, membrane-bound marker of prostate epithelial cells, making it an ideal target for clinical diagnostic and therapeutic applications in the treatment and management of prostate carcinoma.

  4. Original Articles

    1. Top of page
    2. Cancer—50 Years Later
    3. Editorials
    4. Review Articles
    5. Original Articles
    6. Communications
    7. Correspondence
    1. Anatomic Site

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      Preliminary report of the asian-oceanian clinical oncology association randomized trial comparing cisplatin and epirubicin followed by radiotherapy versus radiotherapy alone in the treatment of patients with locoregionally advanced nasopharyngeal carcinoma (pages 2270–2283)

      Daniel T. T. Chua, Jonathan S. T. Sham, Damon Choy, Virchan Lorvidhaya, Yupa Sumitsawan, Sumitra Thongprasert, Visoot Vootiprux, Arkom Cheirsilpa, Tahir Azhar and Ary H. Reksodiputro

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981201)83:11<2270::AID-CNCR6>3.0.CO;2-T

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      In this randomized multicenter trial of 334 patients with locoregionally advanced nasopharyngeal carcinoma, no significant gains in relapse free or overall survival were demonstrated with the addition of neoadjuvant chemotherapy. In a subgroup analysis based on 286 evaluable patients, the addition of neoadjauvant chemotherapy reduced the overall incidence of recurrence, but survival was again not affected. See also pages 2255-8.

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      Prognostic significance of DNA flow cytometric analysis in patients with nasopharyngeal carcinoma (pages 2284–2292)

      Timothy T. C. Yip, W. H. Lau, John K. C. Chan, Roger K. C. Ngan, Y. F. Poon, C. W. Lung, T. Y. Lo and John H. C. Ho

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981201)83:11<2284::AID-CNCR7>3.0.CO;2-J

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      DNA flow cytometric analysis could be prognostically useful in differentiating nasopharyngeal carcinoma patients with poor survival and frequent recurrence.

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      Liver embolizations of patients with malignant neuroendocrine gastrointestinal tumors (pages 2293–2301)

      B. K. Eriksson, E. G. Larsson, B. M. Skogseid, A. M. Löfberg, L. E. Lörelius and K. E. Öberg

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981201)83:11<2293::AID-CNCR8>3.0.CO;2-E

      This study reports the value of arterial liver embolizations performed with gel foam powder relatively late in the clinical courses of neuroendocrine gastrointestinal tumors. The results indicate that "late" embolizations are as effective as "early" embolizations for patients with carcinoid tumors, whereas for patients with endocrine pancreatic tumors earlier embolizations may improve the results and survival.

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      Long term prognosis after hepatectomy for hepatocellular carcinoma : A survival analysis of 204 consecutive patients (pages 2302–2311)

      Hung Lau, Sheung Tat Fan, Irene O. L. Ng and John Wong

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981201)83:11<2302::AID-CNCR9>3.0.CO;2-1

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      A survival analysis was performed on 204 consecutive patients who underwent hepatectomy for hepatocellular carcinoma. pTNM classification and preoperative indocyanine green retention value at 15 minutes were the most important prognostic factors affecting the long term survival of these patients.

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      Clinicopathologic features of patients with hepatocellular carcinoma surviving >10 years after hepatic resection (pages 2312–2316)

      Ken Shirabe, Mitsuo Shimada, Kiyoshi Kajiyama, Tomonobu Gion, Yasuharu Ikeda, Hirofumi Hasegawa, Kenichi Taguchi, Kenji Takenaka and Keizo Sugimachi

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981201)83:11<2312::AID-CNCR10>3.0.CO;2-6

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      Good liver function, hepatitis B surface antigen positivity, and low concentration of serum hepatitis C virus (HCV) RNA in patients with HCV-related hepatocellular carcinoma are potentially good predictors of survival >10 years after hepatic resection.

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      A Phase II pilot trial of 13-cis retinoic acid and interferon-α in patients with advanced pancreatic carcinoma (pages 2317–2323)

      Felix H. Brembeck, Klaus Schoppmeyer, Ursula Leupold, Costel Gornistu, Volker Keim, Joachim Mössner, Ernst-Otto Riecken and Stefan Rosewicz

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981201)83:11<2317::AID-CNCR11>3.0.CO;2-P

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      Combination therapy with 13-cis retinoic acid and interferon-α in patients with advanced pancreatic carcinoma has been shown to be a feasible and well tolerated therapeutic regimen in a Phase II pilot trial. The authors observed one partial response and approximately 67% of patients had prolonged stable disease.

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      Altered p53 is associated with aggressive behavior of chondrosarcoma : A long term follow-up study (pages 2324–2334)

      Yumi Oshiro, Vijaya Chaturvedi, Dorothy Hayden, Tipu Nazeer, Mark Johnson, Dennis A. Johnston, Nelson G. Ordóñez, Alberto G. Ayala and Bogdan Czerniak

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981201)83:11<2324::AID-CNCR12>3.0.CO;2-U

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      Overexpression or alteration of the p53 gene is associated with aggressive clinical behavior of chondrosarcoma of bone.

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      The histologic phenotypes of breast carcinoma occurring before age 40 years in women with and without BRCA1 or BRCA2 germline mutations : A population-based study (pages 2335–2345)

      Jane E. Armes, A. J. Matthew Egan, Melissa C. Southey, Gillian S. Dite, Margaret R. E. McCredie, Graham G. Giles, John L. Hopper and Deon J. Venter

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981201)83:11<2335::AID-CNCR13>3.0.CO;2-N

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      Tumors from women identified from a population-based study with breast carcinoma diagnosed before age 40 years and who carried a germline protein truncating mutation in either BRCA1 or BRCA2 exhibited distinct histologic characteristics constituting recognizable histologic phenotypes. These phenotypes are independent of a family history of breast carcinoma and their recognition could be used in cancer clinics prior to genetic testing to identify those individuals likely to carry a germline mutation in these genes. See also pages 2251-4.

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      Radiation-enhanced expression of E6/E7 transforming oncogenes of human papillomavirus-16 in human cervical carcinoma (pages 2346–2352)

      Alessandro D. Santin, Paul L. Hermonat, Antonella Ravaggi, Maurizio Chiriva-Internati, Sergio Pecorelli and Groesbeck P. Parham

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981201)83:11<2346::AID-CNCR14>3.0.CO;2-G

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      Irradiation-induced up-regulation of the expression of E6/E7 transforming oncoproteins in human papillomavirus-16-infected cervical carcinoma cells could enhance their tumor immunogenicity but also may confer a more malignant phenotype to radiation-resistant tumor cells.

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      Surgical control of clinically localized prostate carcinoma is equivalent in African-American and White males (pages 2353–2360)

      Christophe E. Iselin, James W. Box, Robin T. Vollmer, Lester J. Layfield, Judith E. Robertson and David F. Paulson

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981201)83:11<2353::AID-CNCR15>3.0.CO;2-L

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      The comparison between outcome in African-American and white males with localized prostate carcinoma showed no significant difference. However, African-American males with positive surgical margins did less well than white males, suggesting greater aggressiveness of biologic residual disease in the African-American population. Because prostate carcinoma occurred earlier in the African-American population and local extent of disease impacts on outcome, African-American males would benefit from early detection programs.

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      Immunohistochemical analysis of metallothionein in astrocytic tumors in relation to tumor grade, proliferative potential, and survival (pages 2361–2369)

      Tsuyoshi Hiura, Humayun Khalid, Hiromi Yamashita, Yoshiharu Tokunaga, Akio Yasunaga and Shobu Shibata

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981201)83:11<2361::AID-CNCR16>3.0.CO;2-N

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      The expression of metallothionein (MT) in astrocytic tumors correlates with histologic grade and tumor Ki-67 labeling index. In this study, MT positive anaplastic astrocytoma and glioblastoma patients did not survive as long as those who were negative. Because MT is related to cisplatin resistance, it may be beneficial to assess the MT level in tumors during cisplatin chemotherapy for patients with astrocytic tumors.

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      Cladribine in the treatment of advanced relapsed or refractory low and intermediate grade non-Hodgkin's lymphoma (pages 2370–2376)

      Anil Tulpule, Gary Schiller, Laura A. Harvey-Buchanan, Myung Lee, Byron M. Espina, Aziz U. Khan, William Boswell, Bharat Nathwani and Alexandra M. Levine

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981201)83:11<2370::AID-CNCR17>3.0.CO;2-M

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      Cladribine as a single agent is associated with major responses in one-third of treated patients with refractory or relapsed advanced stage indolent lymphoma.

    13. General Topic

      Cancer among Native Americans
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      Patterns of cancer mortality among Native Americans (pages 2377–2383)

      Nathaniel Cobb and Roberta E. Paisano

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981201)83:11<2377::AID-CNCR18>3.0.CO;2-Z

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      Compared with other racial groups in the U.S., American Indians and Alaska Natives experience quite different patterns of cancer mortality. See also pages 2247-50.

    14. Cancer Prevention
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      Volunteers as adjunct researchers in a cancer prevention trial : The American Cancer Society Colon Polyp Prevention Study (pages 2384–2390)

      Patricia C. Edinboro, Walter Lawrence Jr., Daniel W. Nixon, Alvin Zfass, P. Frederick Duckworth Jr. and Riguey King

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981201)83:11<2384::AID-CNCR19>3.0.CO;2-3

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      Volunteers can be trained to perform selected data collecting activities on a consistent and effective basis, thus allowing a large scale clinical trial to operate at reduced personnel costs.

    15. Pediatric Oncology
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      Prognostic factors in pediatric spinal cord astrocytoma (pages 2391–2399)

      Eric Bouffet, Alain Pierre-Kahn, Jean Claude Marchal, Anne Jouvet, Chantal Kalifa, Maurice Choux, Patrick Dhellemmes, Jean Guérin, Michel Tremoulet and Carmine Mottolese

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981201)83:11<2391::AID-CNCR20>3.0.CO;2-0

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      This retrospective study of pediatric spinal cord astrocytomas emphasizes the role of histology and presenting symptoms as major factors influencing the outcome.

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      Comparative activity of cisplatin, ifosfamide, doxorubicin, carboplatin, and etoposide in heterotransplanted hepatoblastoma (pages 2400–2407)

      Jörg Fuchs, Marc Wenderoth, Dietrich von Schweinitz, Johann Haindl and Ivo Leuschner

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981201)83:11<2400::AID-CNCR21>3.0.CO;2-6

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      Hepatoblastoma is a transplantable tumor in nude mice that resembles its human counterpart with respect to histologic and functional phenotype. Cisplatin and doxorubicin are the most effective agents for the treatment of xenotransplanted hepatoblastoma.

  5. Communications

    1. Top of page
    2. Cancer—50 Years Later
    3. Editorials
    4. Review Articles
    5. Original Articles
    6. Communications
    7. Correspondence
    1. General Topic

      The American College of Surgeons Commission on Cancer and the American Cancer Society
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      The National Cancer Data Base report on patterns of care for adenocarcinoma of the rectum, 1985-1995 (pages 2408–2418)

      J. Milburn Jessup, Andrew K. Stewart and Herman R. Menck

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981201)83:11<2408::AID-CNCR22>3.0.CO;2-G

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      Patients diagnosed with American Joint Committee on Cancer Stage I disease constitute a decreasing proportion of reported cases. Local excision is being employed with greater frequency in the treatment of patients with Stage I disease. The administration of chemotherapy in conjunction with surgery and radiation therapy has increased, particularly in the treatment of patients with Stage II and III disease.

  6. Correspondence

    1. Top of page
    2. Cancer—50 Years Later
    3. Editorials
    4. Review Articles
    5. Original Articles
    6. Communications
    7. Correspondence
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      Efficacy of gemcitabine in the treatment of patients with gallbladder carcinoma : A case report (pages 2419–2420)

      Jorge Gallardo, Miguel Fodor, Claudia Gamargo and Luis Orlandi

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981201)83:11<2419::AID-CNCR23>3.0.CO;2-9

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      Author reply (pages 2420–2421)

      Michael P. Castro

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981201)83:11<2420::AID-CNCR24>3.0.CO;2-W

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      Thyroid papillary carcinoma of columnar cell type : A clinicopathologic study of 16 cases (pages 2421–2422)

      Silvana Pilotti, Paola Collini, Giuseppe Sampietro, Antonella Manzari, Ettore Marubini and Franco Rilke

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981201)83:11<2421::AID-CNCR25>3.0.CO;2-Q

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      Author reply (pages 2422–2423)

      Bruce M. Wenig and Clara S. Heffess

      Version of Record online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981201)83:11<2422::AID-CNCR26>3.0.CO;2-K

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