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Cancer

Cover image for Cancer

15 December 1998

Volume 83, Issue 12

Pages 2425–2658

  1. Cancer—50 Years Later

    1. Top of page
    2. Cancer—50 Years Later
    3. Editorials
    4. Review Articles
    5. Original Articles
    6. Communications
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      "Multiple primary carcinomas of the large intestine"-50 years later (pages 2425–2426)

      Bernard Levin

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981215)83:12<2425::AID-CNCR1>3.0.CO;2-#

      The report by Thomas et al. in the first volume of Cancer 50 years ago concerned 132 patients with multiple primary lesions of the colon who underwent surgical treatment between 1907 and 1944. Since that time, there has been a tremendous increase in knowledge regarding colon carcinoma and two significant points discussed in the original article-family history and "right-sidedness" of multiple primary lesions-now are recognized to be prominent features of this entity.

  2. Editorials

    1. Top of page
    2. Cancer—50 Years Later
    3. Editorials
    4. Review Articles
    5. Original Articles
    6. Communications
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      Economic analysis of expensive technologies : The case of erythropoietin (pages 2427–2429)

      Jennifer J. Griggs and Alvin I. Mushlin

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981215)83:12<2427::AID-CNCR2>3.0.CO;2-V

      Despite its limitations, the willingness-to-pay approach can inform decision-makers regarding the cost-benefit of new technologies used in health care. See also pages 2588-96.

    2. Counterpoint

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      Experience enhances mammographic interpretation, doesn't it? (pages 2430–2431)

      Myron Moskowitz

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981215)83:12<2430::AID-CNCR3>3.0.CO;2-W

      The presence of smaller cancers in the population described by Schmidt et al. in this issue of Cancer cannot be taken to mean that radiologists dedicated to mammography interpret mammograms better than general radiologists do. They may well do so, but these data cannot prove that postulate.

      See also pages 2432-3 and 2516-20.

    3. Reply to Counterpoint

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      Experience enhances mammographic interpretation, doesn't it? yes, it Does! (pages 2432–2433)

      Ferdinand Schmidt, Karin A. Hartwagner, Elke B. Spork and Reinhard Groell

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981215)83:12<2432::AID-CNCR4>3.0.CO;2-R

      It is, of course, difficult to prove in a nonprospective study that dedication and training are the reasons that more small, curable breast carcinomas are detected, but the authors are convinced that their study shows just that.

      See also pages 2430-1 and 2516-20.

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      The National Cancer Data Base report on thyroid carcinoma : Reflections of practice patterns (pages 2434–2436)

      Ashok R. Shaha

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981215)83:12<2434::AID-CNCR5>3.0.CO;2-M

      The National Cancer Data Base has launched collaborative efforts in the collection of data related to various cancers from a large number of institutions. Precise interpretation of these data may be difficult when analyzing critical issues; however, these data do reflect current practice patterns.

      See also pages 2638-48.

  3. Review Articles

    1. Top of page
    2. Cancer—50 Years Later
    3. Editorials
    4. Review Articles
    5. Original Articles
    6. Communications
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      Malignant mesothelioma of the tunica vaginalis testis : Review of the literature and assessment of prognostic parameters (pages 2437–2446)

      Eugen Plas, Claus R. Riedl and Heinz Pflüger

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981215)83:12<2437::AID-CNCR6>3.0.CO;2-G

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      Malignant mesotheliomas of the tunica vaginalis testis are rare tumors that are usually seen in patients in the fifth and sixth decades of life, although 10% of the patients reported in the literature were younger than 25 years. An investigation of prognostic parameters determined that a patient's age and the presence of primary disseminated disease were factors significantly correlated with survival.

  4. Original Articles

    1. Top of page
    2. Cancer—50 Years Later
    3. Editorials
    4. Review Articles
    5. Original Articles
    6. Communications
    1. Anatomic Site

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      Reduced expression of cyclin-dependent kinase inhibitor p27Kip1 is an indicator of malignant behavior in oral squamous cell carcinoma (pages 2447–2455)

      Yasusei Kudo, Takashi Takata, Wataru Yasui, Ikuko Ogawa, Mutsumi Miyauchi, Toshitsugu Takekoshi, Eiichi Tahara and Hiromasa Nikai

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981215)83:12<2447::AID-CNCR7>3.0.CO;2-A

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      A study of 70 patients with oral squamous cell carcinoma indicated that the reduced expression of p27Kip1 correlated with its malignancy and poor prognosis. Oral squamous cell carcinoma cell lines with negative expression of p27Kip1 protein induced the accumulation of this protein by proteasome inhibitor.

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      Nuclear accumulation of p53 in colorectal adenocarcinoma : Prognostic importance differs with race and location of the tumor (pages 2456–2467)

      Upender Manne, Heidi L. Weiss, Russell B. Myers, Omar K. Danner, Cecilia Moron, Sudhir Srivastava and William E. Grizzle

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981215)83:12<2456::AID-CNCR8>3.0.CO;2-5

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      Nuclear accumulation of p53 was found to be a strong predictor of poor survival in white patients but not in African-American patients with primary adenocarcinomas of the proximal colon and was not of prognostic value in patients of either race with primary adenocarcinomas of the distal colorectum.

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      Serum α-L-fucosidase activity and early detection of hepatocellular carcinoma : A prospective study of patients with cirrhosis (pages 2468–2474)

      Maria G. Giardina, Margherita Matarazzo, Roberto Morante, Antonio Lucariello, Antonio Varriale, Vincenzo Guardasole and Giulio De Marco

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981215)83:12<2468::AID-CNCR9>3.0.CO;2-Y

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      During an 8-year follow-up period, 132 cirrhotic patients were monitored by measurement of serum α-L-fucosidase activity and α-fetoprotein and by ultrasonography. During the follow-up, hepatocellular carcinoma was detected in 19 patients. The results of this study show that serum α-L-fucosidase activity, in addition to α-fetoprotein and ultrasonography, is a useful marker in the early diagnosis of hepatocellular carcinoma during the follow-up of cirrhotic patients.

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      A randomized Phase III trial of etoposide, epirubicin, and cisplatin versus 5-fluorouracil, epirubicin, and cisplatin in the treatment of patients with advanced gastric carcinoma (pages 2475–2480)

      Fikri İçli, İsmail Çelik, Faruk Aykan, Aytuǧ Üner, Ahmet Demirkazik, Ahmet Özet, Mustafa Özgüroǧlu, Faruk Taş, Hakan Akbulut and Dinçer Firat

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981215)83:12<2475::AID-CNCR10>3.0.CO;2-H

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      Gastric carcinoma is more common than colorectal carcinoma in Turkey, and the majority of gastric carcinoma patients present with advanced stage disease. In this randomized trial involving patients with advanced gastric carcinoma, the activities of the EEP and FEP combinations (etoposide vs. 5-fluorouracil combined with epirubicin and cisplatin) were found to be limited, without a significant difference between them.

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      Expression of nm23 in gastric carcinoma : Association with tumor progression and poor prognosis (pages 2481–2487)

      Wolfram Müller, Anke Schneiders, Gerhard Hommel and Helmut E. Gabbert

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981215)83:12<2481::AID-CNCR11>3.0.CO;2-P

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      Expression of nm23 is correlated with aggressive tumor growth and poor prognoses for patients with gastric carcinoma, especially diffuse-type carcinoma.

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      Serum CA 125 level as a predictor of peritoneal dissemination in patients with gastric carcinoma (pages 2488–2492)

      Bunzo Nakata, Kosei Hirakawa-YS Chung, Yasuyuki Kato, Yoshito Yamashita, Kiyoshi Maeda, Naoyoshi Onoda, Tetsuji Sawada and Michio Sowa

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981215)83:12<2488::AID-CNCR12>3.0.CO;2-1

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      The serum CA 125 levels of 384 patients with gastric carcinoma were evaluated as a predictor of peritoneal metastasis. Serum CA 125 appears to be the most reliable among those tumor markers and imaging methods currently in clinical use.

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      Tumor proliferation, p53 expression, and apoptosis in laryngeal carcinoma : Relation to the results of radiotherapy (pages 2493–2501)

      Jose Lera, Pedro C. Lara, Sofia Perez, Juan L. Cabrera and Carlos Santana

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981215)83:12<2493::AID-CNCR13>3.0.CO;2-C

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      Ki-67 proliferation measurement and the pretreatment apoptotic index are useful in predicting the clinical outcome of laryngeal carcinoma patients referred for radiotherapy. The role of p53 oncoprotein determination in predicting these outcomes is not clearly defined. The assessment of biologic tumor characteristics could aid in the selection of patients for different treatment strategies.

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      Correlation of tumor size and axillary lymph node involvement with prognosis in patients with T1 breast carcinoma (pages 2502–2508)

      Anthony L. Abner, Laura Collins, Gloria Peiro, Abram Recht, Steven Come, Lawrence N. Shulman, Barbara Silver, Asa Nixon, Jay R. Harris, Stuart J. Schnitt and James L. Connolly

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981215)83:12<2502::AID-CNCR14>3.0.CO;2-I

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      An analysis of patients treated with conservative surgery and radiation therapy demonstrates that microscopic measurement of infiltrating tumor size is correlated more closely with prognosis than is macroscopic tumor size.

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      Breast carcinoma tumor characteristics in black and white women (pages 2509–2515)

      Joann G. Elmore, Victoria M. Moceri, Darryl Carter and Eric B. Larson

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981215)83:12<2509::AID-CNCR15>3.0.CO;2-V

      Black patients with breast carcinoma tend to be diagnosed at a younger age and have different tumor characteristics compared with white patients, with some differences persisting even after controlling for income, medical insurance coverage, and method of tumor detection. These differences may have etiologic and clinical implications.

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      Medical audit after 26,711 breast imaging studies : Improved rate of detection of small breast carcinomas (classified as Tis or T1a,b) (pages 2516–2520)

      Ferdinand Schmidt, Karin A. Hartwagner, Elke B. Spork and Reinhard Groell

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981215)83:12<2516::AID-CNCR16>3.0.CO;2-#

      A mammographic practice requires special personal dedication to achieve a high rate of detection of small, curable breast carcinomas.

      See also pages 2430-1 and 2432-3.

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      Preoperative CA 15-3 concentrations predict outcome of patients with breast carcinoma (pages 2521–2527)

      Stephen G. Shering, Frances Sherry, Enda W. McDermott, Niall J. O'Higgins and Michael J. Duffy

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981215)83:12<2521::AID-CNCR17>3.0.CO;2-A

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      High preoperative levels of the breast-associated antigen CA 15-3 predicted poor outcome of patients with breast carcinoma.

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      Biologic implications of the expression of vascular endothelial growth factor subtypes in ovarian carcinoma (pages 2528–2533)

      Jiro Fujimoto, Hideki Sakaguchi, Reiko Hirose, Satoshi Ichigo and Teruhiko Tamaya

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981215)83:12<2528::AID-CNCR18>3.0.CO;2-N

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      The elevation of VEGF165 might contribute to the advancement of all stages of ovarian carcinoma via angiogenic activity.

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      Very frequent p53 mutations in metastatic prostate carcinoma and in matched primary tumors (pages 2534–2539)

      Frederick J. Meyers, Paul H. Gumerlock, Sung Gil Chi, Holger Borchers, Arline D. Deitch and Ralph W. deVere White

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981215)83:12<2534::AID-CNCR19>3.0.CO;2-V

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      The frequency of mutant p53 in bone marrow metastases of patients with carcinoma of the prostate (CaP) and in matched sets of metastatic and primary lesions from the same patients was investigated. p53 mutations were found to be associated with increased metastatic potential of CaP.

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      The importance of human glandular kallikrein and its correlation with different prostate specific antigen serum forms in the detection of prostate carcinoma (pages 2540–2547)

      Franz Recker, Maciej K. Kwiatkowski, Timo Piironen, Kim Pettersson, Gerd Lümmen, Martin Wernli, Johannes Wiefelspütz, Samuel F. Graber, Mark Goepel, Andreas Huber and Reto Tscholl

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981215)83:12<2540::AID-CNCR20>3.0.CO;2-V

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      Human glandular kallikrein (hK2) in serum correlates highly with prostate specific antigen (PSA) serum forms. The hK2/free PSA ratio improves the specificity of tumor detection.

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      Prognostic factors for survival in patients with brain metastases from renal cell carcinoma (pages 2548–2553)

      Stéphane Culine, Mohamed Bekradda, Andrew Kramar, Annie Rey, Bernard Escudier and Jean-Pierre Droz

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981215)83:12<2548::AID-CNCR21>3.0.CO;2-4

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      A multivariate analysis identified two independent adverse prognostic factors for survival of patients with brain metastases from renal carcinoma: a disease free interval ≤ 18 months from initial diagnosis and the presence of other visceral metastases. A prognostic model is proposed to improve the selection of patients who could be included in clinical trials dealing with chemotherapeutic or immunologic approaches.

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      A combination of semiquantative telomerase assay and in-cell telomerase activity measurement using exfoliated urothelial cells for the detection of urothelial neoplasia (pages 2554–2560)

      Kazuma Ohyashiki, Naoyuki Yahata, Junko H. Ohyashiki, Hiroshi Iwama, Shigefumi Hayashi, Keiko Ando, Taku Aizawa, Takaaki Ito, Makoto Miki and Yoshiro Ebihara

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981215)83:12<2554::AID-CNCR22>3.0.CO;2-C

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      The goal of this study was to provide additional information regarding a noninvasive approach to the detection of urologic neoplasia. The study approach, a combination of semiquantative analysis and an in situ TRAP assay used to detect telomerase positive cells, might be a useful tool in the identification and monitoring of patients with this disease.

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      κ-Opioid receptor binding varies inversely with tumor grade in human gliomas (pages 2561–2566)

      Eric C. Pan, Laura M. Bohn, Mariana M. Belcheva, Gail E. Thomas, Anantha N. Manepalli, James Y. Mamone, Frank E. Johnson and Carmine J. Coscia

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981215)83:12<2561::AID-CNCR23>3.0.CO;2-H

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      Specimens obtained at craniotomy from patients with glioma and nonneoplastic brain disorders were evaluated for their κ-opioid receptor binding. The binding density of κ-opioid receptors was greatest in nonneoplastic brain tissue and decreased with higher grades of astrocytoma to glioblastoma multiforme.

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      Psychosocial and physical correlates of survival and recurrence in patients with head and neck carcinoma : Results of a 6-year longitudinal study (pages 2567–2579)

      Maarten F. De Boer, Bart Van den Borne, Jean F. A. Pruyn, Richard M. Ryckman, Lex Volovics, Paul P. Knegt, Cees A. Meeuwis, Ilse Mesters and Carel D. A. Verwoerd

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981215)83:12<2567::AID-CNCR24>3.0.CO;2-X

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      In the current study, N classification was found to be the strongest prognostic indicator with respect to overall survival. Of the psychosocial predictors, high physical self-efficacy and expression of intensive psychosocial complaints at the time of pretreatment measurement were found to have a favorable prognostic value in patients with head and neck carcinoma.

    19. General Topic

      AIDS-Related Non-Hodgkin's Lymphoma
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      Immunotoxin combined with chemotherapy for patients with AIDS-related non-Hodgkin's lymphoma (pages 2580–2587)

      David T. Scadden, David P. Schenkein, Zale Bernstein, Barry Luskey, John Doweiko, Anil Tulpule and Alexandra M. Levine

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981215)83:12<2580::AID-CNCR25>3.0.CO;2-C

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      This study demonstrates the safety and feasibility of combined therapy consisting of chemotherapy and a monoclonal antibody linked to a cytotoxin. It highlights the potential for this combination approach to the treatment of AIDS-related lymphoma.

    20. Chemotherapy: Costs
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      What are cancer patients willing to pay for prophylactic epoetin alfa? : A cost-benefit analysis (pages 2588–2596)

      Ana Ortega, George Dranitsaris and Anitasha L. V. Puodziunas

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981215)83:12<2588::AID-CNCR26>3.0.CO;2-M

      In this study, cancer patients perceived that the clinical benefit of epoetin alfa is not worth its cost.

      See also pages 2427-9.

    21. Chemotherapy: Toxicity
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      Mississippi mud in the 1990s : Risks and outcomes of vancomycin-associated toxicity in general oncology practice (pages 2597–2607)

      Linda S. Elting, Edward B. Rubenstein, Danna Kurtin, Kenneth V. I. Rolston, John Fangtang, Charles G. Martin, Issam I. Raad, Estella E. Whimbey, Ellen Manzullo and Gerald P. Bodey

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981215)83:12<2597::AID-CNCR27>3.0.CO;2-L

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      Vancomycin-associated toxicities generally are mild and self-limited. Although some patients are at a significantly higher risk of nephrotoxicity, they can be identified reliably by using the Nephrotoxicity Risk Index at the time of vancomycin initiation.

    22. Pediatric Oncology
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      A longitudinal magnetic resonance imaging study of the brain in survivors of childhood acute lymphoblastic leukemia (pages 2608–2617)

      Arja H. Harila-Saari, Eija L. Pääkkö, Leena K. Vainionpää, Juhani Pyhtinen and B. Marjatta Lanning

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981215)83:12<2608::AID-CNCR28>3.0.CO;2-L

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      Abnormalities in magnetic resonance imaging scans of the brain are infrequent during the first 5 years after treatment for childhood acute lymphoblastic leukemia and do not correlate significantly with neuropsychologic outcome.

  5. Communications

    1. Top of page
    2. Cancer—50 Years Later
    3. Editorials
    4. Review Articles
    5. Original Articles
    6. Communications
    1. General Topic

      The American College of Surgeons Commission on Cancer and the American Cancer Society
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      The National Cancer Data Base report on carcinoma of the gallbladder, 1989-1995 (pages 2618–2628)

      John H. Donohue, Andrew K. Stewart and Herman R. Menck

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981215)83:12<2618::AID-CNCR29>3.0.CO;2-H

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      Time trends in patterns of care for gallbladder carcinoma were analyzed for this report. It was found that younger patients are more frequently diagnosed with more advanced disease than older patients. Differences in treatment patterns were observed among patients of different age and stage groups. A large proportion of patients diagnosed with metastatic disease did not receive definitive therapy. Surgery alone is being utilized more often in the initial treatment of gallbladder carcinomas. Survival outcomes are directly related to stage of disease at diagnosis; however, the utilization of more aggressive therapy does not result in noticeably superior patient outcomes.

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      The National Cancer Data Base report on endometrial carcinoma in African-American women (pages 2629–2637)

      Michael L. Hicks, Jerri Linn Phillips, Groesbeck Parham, Nancy Andrews, Walter B. Jones, Hugh M. Shingleton and Herman R. Menck

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981215)83:12<2629::AID-CNCR30>3.0.CO;2-2

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      African-American women with endometrial carcinoma were diagnosed with less favorable prognostic factors than white women, were treated less often for their tumor, and were treated less aggressively. Survival of African-American patients was substantially poorer than that of white patients.

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      A National Cancer Data Base report on 53,856 cases of thyroid carcinoma treated in the U.S., 1985-1995 (pages 2638–2648)

      Scott A. Hundahl, Irvin D. Fleming, Amy M. Fremgen and Herman R. Menck

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981215)83:12<2638::AID-CNCR31>3.0.CO;2-1

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      Patterns of care, overall survival, and stage-stratified survival for 53,856 cases of thyroid carcinoma accessioned to the National Cancer Data Base between 1985 and 1995 were examined.

      See also pages 2434-6.

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      Regional diversity and breadth of the National Cancer Data Base (pages 2649–2658)

      Herman R. Menck, Kirby I. Bland, Carol E. H. Scott-Conner, Harmon J. Eyre, Gerald P. Murphy and David P. Winchester

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19981215)83:12<2649::AID-CNCR32>3.0.CO;2-V

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      The degree of diversity in the medical care of cancer patients diagnosed in 1995 at U.S. cancer hospitals and reported to the National Cancer Data Base is presented.

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