Cell motility as a prognostic factor in Stage I nonsmall cell lung carcinoma
The role of gelsolin expression
Article first published online: 19 NOV 2000
Copyright © 1999 American Cancer Society
Volume 85, Issue 1, pages 47–57, 1 January 1999
How to Cite
Shieh, D.-B., Godleski, J., Herndon, J. E., Azuma, T., Mercer, H., Sugarbaker, D. J. and Kwiatkowski, D. J. (1999), Cell motility as a prognostic factor in Stage I nonsmall cell lung carcinoma. Cancer, 85: 47–57. doi: 10.1002/(SICI)1097-0142(19990101)85:1<47::AID-CNCR7>3.0.CO;2-L
- Issue published online: 19 NOV 2000
- Article first published online: 19 NOV 2000
- Manuscript Revised: 27 MAY 1998
- Manuscript Accepted: 27 MAY 1998
- Manuscript Received: 20 MAR 1998
- NIH. Grant Number: R01 HL54188
- nonsmall cell lung carcinoma;
- prognostic factors;
Tumor cell motility is an important characteristic that facilitates the multistep process of tumor metastasis. Rac, ABP-280, and gelsolin are proteins that interact with actin and are important in cell motility.
The authors studied a cohort of 229 Stage I nonsmall cell lung carcinoma (NSCLC) patients who had a minimum of 3 years follow-up and had been previously analyzed for 22 clinical, pathologic, and molecular features, of which 9 had been found to provide significant prognostic information in a Cox proportional hazards model. Tumor sections were stained by the avidin-biotin complex method using monoclonal antibodies against rac, ABP-280, and gelsolin.
In a pilot analysis of over 50 patients each, rac and ABP-280 were found to be moderately-to-highly expressed in the majority of tumors and to provide no prognostic information. Gelsolin expression was more variable and appeared to be negatively correlated with survival in the pilot population. In the larger 229-patient population, high focal gelsolin expression was seen in 32 tumors (14%) and conferred the highest relative risk (4.04) of cancer recurrence among all factors tested, compared with tumors that had no or low gelsolin expression. Moderate focal gelsolin expression, seen in 46 patients (20%), also conferred a significant risk of cancer recurrence, with a relative risk of 2.26 compared with tumors that had no or low gelsolin expression. Consideration of average gelsolin expression and of overall survival yielded similar results.
Gelsolin expression appears to be a significant prognostic factor for cancer recurrence in cases of Stage I NSCLC. Cancer 1999;85:47–57. © 1999 American Cancer Society.