You have free access to this content

Cancer

Cover image for Cancer

1 February 1999

Volume 85, Issue 3

Pages 517–756

  1. Editorial

    1. Top of page
    2. Editorial
    3. Original Article
    4. Correspondence
    1. You have free access to this content
      Transforming growth factor-β1 : A useful tumor marker in patients with colorectal carcinoma? (pages 517–519)

      Alan D. Langerak and Harinder S. Garewal

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<517::AID-CNCR1>3.0.CO;2-K

      Although transforming growth factor-β1 may prove to be an important new tumor marker in colorectal carcinoma, larger, prospective studies are needed to confirm this theory.

      See referenced original article on pages 554-61.

  2. Original Article

    1. Top of page
    2. Editorial
    3. Original Article
    4. Correspondence
    1. Anatomic Site

      You have free access to this content
      Pathologic prognostic factors in Barrett's-associated adenocarcinoma : A follow-up study of 96 patients (pages 520–528)

      Carlos Torres, Jerrold R. Turner, Helen H. Wang, William Richards, David Sugarbaker, Ali Shahsafaei and Robert D. Odze

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<520::AID-CNCR2>3.0.CO;2-L

      • original image
      • original image

      A retrospective study of morphologic prognostic features in 96 cases of resected Barrett's-associated adenocarcinoma, either with (61 cases) or without (35 cases) preoperative neoadjuvant chemoradiotherapy, found that older patient age, higher pathologic stage, absence of peritumoral lymphoid infiltrate, and most likely perineural invasion were associated with shortened survival by multivariate analysis. The effect of chemoradiotherapy, as assessed by the degree of residual tumor, did not correlate with survival in this patient group.

    2. You have free access to this content
      Successful intraperitoneal hyperthermic chemoperfusion for the prevention of postoperative peritoneal recurrence in patients with advanced gastric carcinoma (pages 529–534)

      Shigeru Fujimoto, Makoto Takahashi, Takaaki Mutou, Kokuriki Kobayashi and Tadashi Toyosawa

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<529::AID-CNCR3>3.0.CO;2-9

      • original image
      • original image

      Seventy-one gastric carcinoma patients with serosal invasion were treated with intraperitoneal hyperthermic chemoperfusion combined with surgery. The survival rate of these 71 patients was significantly higher than that of the control group of 70 patients who were treated with surgery alone.

    3. You have free access to this content
      5-Fluorouracil and levofolinic acid with or without recombinant interferon-2b in patients with advanced colorectal carcinoma : A randomized multicenter study with stratification for tumor burden and liver involvement by the Southern Italy Oncology Group (pages 535–545)

      Giuseppe Colucci, Evaristo Maiello, Vittorio Gebbia, Francesco Giuliani, Giuseppe Serravezza, Giorgio Lelli, Silvana Leo, Gianfranco Filippelli, Giampaolo Nicolella and Mario Brandi

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<535::AID-CNCR4>3.0.CO;2-7

      • original image
      • original image
      • original image

      A Phase III trial was performed to evaluate the impact of interferon on the efficacy of levofolinic acid and 5-fluorouracil against metastatic colorectal carcinoma, as well as the role of tumor burden and liver involvement as prognostic factors. Interferon did not appear to have a positive influence on patient outcome, although liver involvement and tumor burden were found to be important prognostic factors.

    4. You have free access to this content
      Amplified CDK2 and cdc2 activities in primary colorectal carcinoma (pages 546–553)

      Jong Hun Kim, Min Jeong Kang, Chul Uhng Park, Hee Jin Kwak, Yong Hwang and Gou Young Koh

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<546::AID-CNCR5>3.0.CO;2-0

      • original image
      • original image
      • original image
      • original image
      • original image
      • original image

      The results of this study indicate that significant activation of CDK2 and cdc2 occurs in primary colorectal carcinoma.

    5. You have free access to this content
      Elevated serum levels of transforming growth factor-β1 in patients with colorectal carcinoma : Its association with tumor progression and its significant decrease after curative surgical resection (pages 554–561)

      Kang Sup Shim, Kwang Ho Kim, Woon Sup Han and Eung Bum Park

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<554::AID-CNCR6>3.0.CO;2-X

      • original image
      • original image
      • original image
      • original image
      • original image

      Serum levels of transforming growth factor-β1 (TGF-β1) in patients with colorectal carcinoma were significantly higher than those in normal control subjects and these levels decreased significantly after curative surgical resection. These results suggest that the serum level of TGF-β1 might be a useful biomarker in the management of colorectal carcinoma. See also pages 517–9.

    6. You have free access to this content
      Epithelioid hemangioendothelioma of the liver : A clinicopathologic study of 137 cases (pages 562–582)

      Hala R. Makhlouf, Kamal G. Ishak and Zachary D. Goodman

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<562::AID-CNCR7>3.0.CO;2-T

      • original image
      • original image
      • original image
      • original image
      • original image
      • original image
      • original image
      • original image
      • original image
      • original image
      • original image
      • original image
      • original image
      • original image
      • original image
      • original image
      • original image
      • original image
      • original image
      • original image
      • original image
      • original image
      • original image

      To the authors' knowledge, this series of 137 cases is the largest series reported from one institution. Epithelioid hemangioendothelioma is of unknown etiology and only one histologic parameter, tumor cellularity, is predictive of outcome.

    7. You have free access to this content
      Analysis of paraaortic lymph node involvement in pancreatic carcinoma : A significant indication for surgery? (pages 583–590)

      Masato Kayahara, Takukazu Nagakawa, Tetsuo Ohta, Hirohisa Kitagawa, Keiichi Ueno, Hidehiro Tajima, Ayman Elnemr and Koichi Miwa

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<583::AID-CNCR8>3.0.CO;2-J

      • original image
      • original image
      • original image
      • original image
      • original image
      • original image
      • original image
      • original image
      • original image

      Paraaortic lymph node involvement in invasive ductal carcinoma of the pancreas is common and highly significant for prognosis. Therefore the resected specimen should include the paraaortic lymph nodes.

    8. You have free access to this content
      Spontaneous apoptosis in laryngeal squamous cell carcinoma is independent of bcl-2 and bax protein expression (pages 591–599)

      Martin C. Jäckel, Mansur A. Dorudian, Dagmar Marx, Ulrich Brinck, Alfred Schauer and Wolfgang Steiner

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<591::AID-CNCR9>3.0.CO;2-F

      • original image
      • original image
      • original image
      • original image

      In this study, the rate of spontaneous apoptosis occurring in laryngeal carcinoma was closely associated with mitotic activity but appeared to be unrelated to protein expression of bcl-2 and bax. Elevated bcl-2 and reduced bax levels were correlated with adverse prognostic parameters.

    9. You have free access to this content
      Genetic changes in the spectrum of neuroendocrine lung tumors (pages 600–607)

      Naoyoshi Onuki, Ignacio I. Wistuba, William D. Travis, Arvind K. Virmani, Kazuo Yashima, Elizabeth Brambilla, Phillip Hasleton and Adi F. Gazdar

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<600::AID-CNCR10>3.0.CO;2-W

      • original image
      • original image
      • original image
      • original image
      • original image
      • original image
      • original image

      The authors studied the molecular changes present in 59 cases representing all 4 types of pulmonary neuroendocrine tumors. Their findings support the clinicopathologic concept that neuroendocrine tumors of the lung represent a spectrum ranging from low grade typical carcinoids to highly malignant neuroendocrine carcinomas.

    10. You have free access to this content
      Extramedullary tumors of myeloid blasts in adults as a pattern of relapse following allogeneic bone marrow transplantation (pages 608–615)

      Yener Koc, Kenneth B. Miller, David P. Schenkein, Philip Daoust, Kellie Sprague and Eugene Berkman

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<608::AID-CNCR11>3.0.CO;2-5

      • original image

      Solitary extramedullary myeloid sarcoma as a pattern of recurrence following allogeneic bone marrow transplantation in patients with acute or chronic myeloid leukemia is rare. The prognosis for this group of patients is very poor, as in any case of posttransplantation leukemic relapse, with the exception of patients with chronic myeloid leukemia.

    11. You have free access to this content
      Predictors of local recurrence after treatment of ductal carcinoma in situ : A meta-analysis (pages 616–628)

      John Boyages M.B.B.S., Geoff Delaney M.B.B.S. and Richard Taylor M.B.B.S.

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<616::AID-CNCR12>3.0.CO;2-7

      • original image
      • original image
      • original image

      Patient tumor and treatment factors as potential predictors for local recurrence after surgery for ductal carcinoma in situ are reviewed. This meta-analysis shows that various pathologic factors and conservative surgery alone are predictors for higher incidence of local recurrence.

    12. You have free access to this content
      Male breast carcinoma : A review of 229 patients who presented to the Princess Margaret Hospital during 40 years: 1955–1996 (pages 629–639)

      Paul E. Goss, Caroline Reid, Melania Pintilie, Ruth Lim and Naomi Miller

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<629::AID-CNCR13>3.0.CO;2-V

      • original image
      • original image

      This single-institution review of 229 male breast carcinoma patients who presented during the years 1955–1996 describes clinical presentation, some changes in treatment practices, and no improvement in outcome over the 4-decade period. Collection of detailed, prospective data on male breast carcinoma patients may optimize clinical management.

    13. You have free access to this content
      Cognitive deficits after postoperative adjuvant chemotherapy for breast carcinoma (pages 640–650)

      Sanne B. Schagen, Frits S. A. M. van Dam, Martin J. Muller, Willem Boogerd, Jaap Lindeboom and Peter F. Bruning

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<640::AID-CNCR14>3.0.CO;2-G

      Breast carcinoma patients treated with adjuvant cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) chemotherapy have a significantly higher risk of late cognitive impairment than breast carcinoma patients not treated with chemotherapy. This cognitive impairment is unaffected by anxiety, depression, fatigue, and time since treatment, and is not related to patients' reports of cognitive dysfunction.

    14. You have free access to this content
      Vascularity index as a novel parameter for the in vivo assessment of angiogenesis in patients with cervical carcinoma (pages 651–657)

      Wen-Fang Cheng, Chien-Nan Lee, Jan-Show Chu, Chi-An Chen, Tzer-Ming Chen, Wen-Yi Shau, Chang-Yao Hsieh and Fon-Jou Hsieh

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<651::AID-CNCR15>3.0.CO;2-9

      • original image
      • original image
      • original image
      • original image
      • original image
      • original image

      In vivo vascularity index was found to correlate well with in vitro microvessel density. The authors believe the in vivo vascularity index would help to predict lymph node metastasis in patients with cervical carcinoma.

    15. You have free access to this content
      Altered expression of transforming growth factor-β ligands and receptors in primary and recurrent ovarian carcinoma (pages 658–668)

      Robert E. Bristow, Rae Lynn Baldwin, S. Diane Yamada, Murray Korc and Beth Y. Karlan

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<658::AID-CNCR16>3.0.CO;2-M

      • original image
      • original image
      • original image
      • original image
      • original image
      • original image
      • original image
      • original image

      Enhanced expression of transforming growth factor-β (TGF-β)1 and TGF-β3 mRNA, as well as loss of expression of TGF-β receptors TβR-I and TβR-III, were observed in ovarian carcinoma specimens, suggesting a role for alterations in TGF-β-mediated pathways in ovarian tumorigenesis.

    16. You have free access to this content
      Clear cell carcinoma has an expression pattern of cell cycle regulatory molecules that is unique among ovarian adenocarcinomas (pages 669–677)

      Motohiko Shimizu, Toshio Nikaido, Toshihiko Toki, Tanri Shiozawa and Shingo Fujii

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<669::AID-CNCR17>3.0.CO;2-F

      • original image
      • original image
      • original image
      • original image
      • original image
      • original image
      • original image

      Clear cell carcinoma exhibits higher expression of cyclin E and p21 and lower expression of p53 and cyclin A than any other histologic subtype of ovarian adenocarcinoma.

    17. You have free access to this content
      Late side effects unchanged 4–8 years after radiotherapy for prostate carcinoma : A comparison with age-matched controls (pages 678–688)

      Per Fransson and Anders Widmark

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<678::AID-CNCR18>3.0.CO;2-E

      • original image
      • original image
      • original image
      • original image

      Changes in complications between 4 and 8 years after radiotherapy were prospectively assessed among prostate carcinoma patients who received a self-assessment questionnaire, and these changes were compared with those found in an age-matched population.

    18. You have free access to this content
      Impact of tumor size on the clinical outcomes of patients with Robson Stage I renal cell carcinoma (pages 689–695)

      Toshiaki Kinouchi, Shigeru Saiki, Norio Meguro, Osamu Maeda, Masao Kuroda, Michiyuki Usami and Toshihiko Kotake

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<689::AID-CNCR19>3.0.CO;2-7

      • original image
      • original image

      The tumor size cutoff of 5.5 cm, rather than 7.0 cm, in the TNM system (fifth edition, 1997) for classifying renal cell carcinoma was most significantly predictive of the survival of Robson Stage I patients after radical nephrectomy. The tumor size cutoff of 5.5 cm was also shown to be significant in univariate and multivariate analyses.

    19. You have free access to this content
      Incidence of breast carcinoma in women with thyroid carcinoma (pages 696–705)

      Rena Vassilopoulou-Sellin, Lynn Palmer, Sarah Taylor and Catherine S. Cooksley

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<696::AID-CNCR20>3.0.CO;2-4

      Breast carcinoma developing after thyroid carcinoma was diagnosed more frequently than expected in young adult women. This potential association and plausible mechanisms should be evaluated in larger cohorts of patients.

    20. You have free access to this content
      The management of unicentric and multicentric Castleman's disease : A report of 16 cases and a review of the literature (pages 706–717)

      Wilbur B. Bowne, Jonathan J. Lewis, Daniel A. Filippa, Ruben Niesvizky, Ari D. Brooks, Michael E. Burt and Murray F. Brennan

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<706::AID-CNCR21>3.0.CO;2-7

      • original image
      • original image
      • original image
      • original image
      • original image
      • original image

      The authors report on the responses to therapy and clinical outcomes of patients with the clinical and histopathologic features of unicentric and multicentric Castleman's disease treated at a single institution. The current understanding of the pathogenesis of this disease in regard to possible treatment strategies is discussed.

    21. You have free access to this content
      p53 gene Mutations and rearrangements in non-Hodgkin's lymphoma (pages 718–724)

      Po-Min Chen, Tzeon-Jye Chiou, Ruey-Kuen Hsieh, Frank S. Fan, Chiau-Jun Chu, Ching-Zong Lin, Hung Chiang, Chueh-Chuan Yen, Wei-Shu Wang and Jin-Hwang Liu

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<718::AID-CNCR22>3.0.CO;2-Y

      • original image
      • original image
      • original image

      Point mutations and rearrangements of the p53 gene were found in 9 (10.8%) of 84 non-Hodgkin's lymphomas. Patients who carried these alterations had worse outcomes than other patients. Of three patients with gene rearrangements, the two with one abnormal p53 allele had a more favorable prognosis than the one with two abnormal alleles.

    22. General Topic

      Pediatric Oncology
      You have free access to this content
      Extraskeletal Ewing's sarcoma (pages 725–731)

      Rick Ahmad, Brian R. Mayol, Mary Davis and Bruce T. Rougraff

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<725::AID-CNCR23>3.0.CO;2-2

      • original image
      • original image
      • original image
      • original image
      • original image

      Combination therapy with chemotherapy, radiation, and attempted surgical resection of the tumor mass in patients younger than 16 years with extraskeletal Ewing's sarcoma was associated with a better survival than that for older patients or those treated without surgical resection.

    23. You have free access to this content
      Military service of male survivors of childhood malignancies (pages 732–740)

      Päivi M. Lähteenmäki, Heikki A. Salmi, Toivo T. Salmi, Hans Helenius, Anne Mäkipernaa, Marjatta Lanning, Mikko Perkkiö and Martti A. Siimes

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<732::AID-CNCR24>3.0.CO;2-7

      • original image

      Childhood cancer survivors are less likely to meet the requirements for military service in Finland, but enlisted survivors cope with the service well if their treatment sequelae are evaluated carefully at the time of military enlistment. The survivors who are eligible for duty are well motivated for training and use the medical services of the garrison physician less than controls, and, as a whole, their service is comparable to that of the general population.

    24. You have free access to this content
      The RNA component of telomerase as a marker of biologic potential and clinical outcome in childhood neuroblastic tumors (pages 741–749)

      Anirban Maitra, Kazuo Yashima, Asha Rathi, Charles F. Timmons, Beverly Barton Rogers, Jerry W. Shay and Adi F. Gazdar

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<741::AID-CNCR25>3.0.CO;2-6

      • original image
      • original image
      • original image
      • original image
      • original image
      • original image

      Neuroblastic tumors are characterized by unpredictable biologic behavior. In this study, the expression of the RNA component of human telomerase (hTR) was examined in archival material from neuroblastic tumors by an in situ hybridization assay, and hTR expression was correlated with prognosis and outcome of therapy.

    25. You have free access to this content
      Childhood melanoma survival (pages 750–754)

      Nicholas C. Saenz, Judit Saenz-Badillos, Klaus Busam, Michael P. LaQuaglia, Martin Corbally and Mary S. Brady

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<750::AID-CNCR26>3.0.CO;2-5

      • original image
      • original image
      • original image

      Like adults, children with melanoma are at significant risk of dying of the disease. The survival of children is similar to that of adults and is related to stage at presentation. The survival advantage observed for adult females is not seen among children.

  3. Correspondence

    1. Top of page
    2. Editorial
    3. Original Article
    4. Correspondence
    1. You have free access to this content

SEARCH

SEARCH BY CITATION