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Cancer

Cover image for Cancer

15 March 1999

Volume 85, Issue 6

Pages 1213–1406

  1. Original Article

    1. Top of page
    2. Original Article
    3. Communication
    1. Anatomic Site

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      Phase II clinical trial of 13-cis-retinoic acid and interferon-α-2a in patients with advanced esophageal carcinoma (pages 1213–1217)

      Peter C. Enzinger, David H. Ilson, Leonard B. Saltz, Lisa K. Martin and David P. Kelsen

      Article first published online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990315)85:6<1213::AID-CNCR1>3.0.CO;2-N

      The combination of interferon-α-2a and 13-cis-retinoic acid previously has been shown to have antitumor activity in squamous cell carcinoma. A Phase II trial of this combination in patients with esophageal squamous cell carcinoma and adenocarcinoma did not reveal any significant antitumor activity.

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      Iodine-125 brachytherapy in the treatment of colorectal adenocarcinoma metastatic to the liver (pages 1218–1225)

      Rafael Martinez-Monge, Subir Nag, Carol A. Nieroda and Edward W. Martin

      Article first published online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990315)85:6<1218::AID-CNCR2>3.0.CO;2-F

      Iodine-125 brachytherapy can be recommended for patients with unresectable or incompletely resected solitary liver metastases from colorectal adenocarcinoma.

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      Overexpression of p53 protein and outcome of patients treated with chemoradiation for carcinoma of the anal canal : A report of randomized trial RTOG 87-04 (pages 1226–1233)

      Steven R. Bonin, Thomas F. Pajak, Anthony H. Russell, Lawrence R. Coia, Kristie J. Paris, Marshall S. Flam and Ed R. Sauter

      Article first published online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990315)85:6<1226::AID-CNCR3>3.0.CO;2-B

      This randomized study suggests that the p53 staining pattern may have prognostic significance for patients treated with chemoradiation for carcinoma of the anal canal. More aggressive treatment may overcome this detrimental effect.

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      Expression of the MAGE gene family in human hepatocellular carcinoma (pages 1234–1240)

      Kouichirou Tahara, Masaki Mori, Noriaki Sadanaga, Yoshihiro Sakamoto, Seigo Kitano and Masatoshi Makuuchi

      Article first published online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990315)85:6<1234::AID-CNCR4>3.0.CO;2-7

      MAGE gene expression is frequent in hepatocellular carcinoma (HCC), suggesting that HCC may be a good candidate for MAGE specific immunotherapy.

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      Carcinoid tumors of the ampulla of Vater : A comparison with duodenal carcinoid tumors (pages 1241–1249)

      Hala R. Makhlouf, Allen P. Burke and Leslie H. Sobin

      Article first published online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990315)85:6<1241::AID-CNCR5>3.0.CO;2-4

      Carcinoid tumors of the ampulla differ clinically, histologically, and immunohistochemically from carcinoid tumors elsewhere in the duodenum.

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      Loss of p27Kip1 expression independently predicts poor prognosis for patients with resectable pancreatic adenocarcinoma (pages 1250–1260)

      Cai-De Lu, Shinsho Morita, Takashi Ishibashi, Hitoshi Hara, Hiroshi Isozaki and Nobuhiko Tanigawa

      Article first published online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990315)85:6<1250::AID-CNCR6>3.0.CO;2-#

      As a universal cyclin-dependent kinase inhibitor, p27Kip1 expression was reduced drastically in patients with pancreatic adenocarcinoma. Patients with resectable tumors displaying >1% p27Kip1 positive tumor cells survived significantly longer than those with p27Kip1 negative tumors.

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      An investigational new drug treatment program for patients with gemcitabine : Results for over 3000 patients with pancreatic carcinoma (pages 1261–1268)

      Anna Maria Storniolo, Nathan H. Enas, Cheryl A. Brown, Maurizio Voi, Mace L. Rothenberg and Richard Schilsky

      Article first published online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990315)85:6<1261::AID-CNCR7>3.0.CO;2-T

      In this series (which, to the authors' knowledge, was the largest series of pancreatic carcinoma patients ever presented in a typical clinical setting), notable disease-related symptom improvement and survival were demonstrated with gemcitabine, and these findings support those of earlier registration trials.

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      Phase I/II trial of paclitaxel by 1-hour infusion, carboplatin, and gemcitabine in the treatment of patients with advanced nonsmall cell lung carcinoma (pages 1269–1276)

      John D. Hainsworth, Howard A. Burris III, Joan B. Erland, Lisa H. Morrissey, Anthony A. Meluch, Leonard A. Kalman, Jeremy K. Hon, Daniel C. Scullin Jr., Steven W. Smith and F. Anthony Greco

      Article first published online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990315)85:6<1269::AID-CNCR8>3.0.CO;2-I

      In this Phase I/II trial, a third active drug, gemcitabine, was added to a standard paclitaxel/carboplatin regimen for the treatment of patients with advanced nonsmall cell lung carcinoma. This regimen was feasible and active, with a 44% response rate and actuarial 45% 1-year survival in a multicenter study.

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      Estrogen replacement therapy in women with a history of proliferative breast disease (pages 1277–1283)

      William D. Dupont, David L. Page, Fritz F. Parl, W. Dale Plummer Jr., Peggy A. Schuyler, Masako Kasami and Roy A. Jensen

      Article first published online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990315)85:6<1277::AID-CNCR9>3.0.CO;2-E

      Estrogen replacement therapy does not significantly elevate the risk of invasive breast carcinoma in women with a history of different types of histologically defined benign breast disease. This therapy is not contraindicated in these women.

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      A randomized trial of tamoxifen alone or combined with octreotide in the treatment of women with metastatic breast carcinoma (pages 1284–1292)

      James N. Ingle, Vera J. Suman, Carl G. Kardinal, James E. Krook, James A. Mailliard, Michael H. Veeder, Charles L. Loprinzi, Robert J. Dalton, Lynn C. Hartmann, Cheryl A. Conover and Michael N. Pollak

      Article first published online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990315)85:6<1284::AID-CNCR10>3.0.CO;2-P

      A randomized trial of tamoxifen alone or combined with octreotide revealed no indication that the combination was substantially more efficacious in the treatment of postmenopausal women with metastatic breast carcinoma.

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      p53 Protein overexpression is associated with increased cell proliferation in patients with locally recurrent prostate carcinoma after radiation therapy (pages 1293–1299)

      Liang Cheng, Thomas J. Sebo, John C. Cheville, Thomas M. Pisansky, Jeff Slezak, Erik J. Bergstralh, Anna Pacelli, Roxann M. Neumann, Horst Zincke and David G. Bostwick

      Article first published online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990315)85:6<1293::AID-CNCR11>3.0.CO;2-O

      Patients selected for salvage prostatectomy had recurrent prostate carcinoma that remained biologically aggressive after radiation therapy. Increased p53 nuclear accumulation correlated with cellular proliferative activity, both of which were found in a high proportion of study patients.

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      Predictors of cancer progression in T1a prostate adenocarcinoma (pages 1300–1304)

      Liang Cheng, Erik J. Bergstralh, Beth G. Scherer, Roxann M. Neumann, Michael L. Blute, Horst Zincke and David G. Bostwick

      Article first published online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990315)85:6<1300::AID-CNCR12>3.0.CO;2-#

      The clinical course of patients with T1a prostate adenocarcinoma is variable. If left untreated, a small but significant proportion of patients are at risk for cancer progression and death. Patients with a transurethral resection tissue weight ≥ 30 g have an excellent prognosis and can be managed conservatively.

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      Demographics, family histories, and psychological characteristics of prostate carcinoma screening participants (pages 1305–1312)

      Kathryn L. Taylor, Joanne DiPlacido, William H. Redd, Karen Faccenda, Linda Greer and Aaron Perlmutter

      Article first published online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990315)85:6<1305::AID-CNCR13>3.0.CO;2-I

      Among a sample of men seeking prostate carcinoma screening, the authors investigated the association of family history of prostate carcinoma with 1) the reasons men seek screening, and 2) their levels of psychological distress and perceived risk. The findings suggested that self-referral was the most common reason for seeking screening. Perceived risk for prostate carcinoma was higher among men with a family history, and psychological distress was greater among men with a family history only among those who also reported elevated perceived risk.

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      Short term pretreatment with medroxyprogesterone and testosterone may potentiate irradiation damage to spermatogenesis in rats (pages 1313–1322)

      Samira Es-slami, Sébastien Charcellay, Ghislaine Pinon-Lataillade and Jean-Claude Soufir

      Article first published online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990315)85:6<1313::AID-CNCR14>3.0.CO;2-K

      It has been claimed that a short period of steroid pretreatment protects the testis from irradiation damage. However, we show here that this pretreatment may exacerbate the effects of irradiation on germ cells, especially the survival and genomic alteration of stem cells.

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      Expression of vascular endothelial growth factor in patients with testicular germ cell tumors as an indicator of metastatic disease (pages 1323–1330)

      Souichirou Fukuda, Tsutomu Shirahama, Yoshiharu Imazono, Tomoyasu Tsushima, Hiroyuki Ohmori, Tsuneyoshi Kayajima, Saburou Take, Kenryu Nishiyama, Suguru Yonezawa, Suminori Akiba, Shin-ichi Akiyama and Yoshitada Ohi

      Article first published online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990315)85:6<1323::AID-CNCR15>3.0.CO;2-G

      Expression of vascular endothelial growth factor is a hallmark of testicular germ cell tumor development, and is related to angiogenesis and metastatic disease.

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      Resection of small, residual retroperitoneal masses after chemotherapy for nonseminomatous testicular cancer : A decision analysis (pages 1331–1341)

      Ewout W. Steyerberg, Phillip B. Marshall, H. Jan Keizer and J. Dik F. Habbema

      Article first published online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990315)85:6<1331::AID-CNCR16>3.0.CO;2-I

      According to a decision analysis model, surgical resection resulted in a greater survival benefit than observation for patients with small, retroperitoneal residual masses after chemotherapy for metastatic, nonseminomatous testicular cancer. The benefit, however, depended on clinical characteristics and the prognosis of unresected residual malignancy, which supports an individualized approach to decision-making regarding resection.

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      Unusual clinical presentation of upper urothelial carcinoma in Taiwan (pages 1342–1344)

      Yii-Her Chou and Chun-Hsiung Huang

      Article first published online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990315)85:6<1342::AID-CNCR17>3.0.CO;2-B

      The gender incidence (showing a slight female predominance) and ratio of renal pelvic transitional cell carcinoma to all renal carcinomas (40%) were found to be different in Taiwan in contrast to the majority of other reports.

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      Unusual features of thyroid carcinomas in Japanese patients with Werner syndrome and possible genotype–phenotype relations to cell type and race (pages 1345–1352)

      Yuichi Ishikawa, Haruo Sugano, Takehisa Matsumoto, Yasuhiro Furuichi, Robert W. Miller and Makoto Goto

      Article first published online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990315)85:6<1345::AID-CNCR18>3.0.CO;2-#

      Thyroid carcinomas in Japanese patients with Werner syndrome, as compared with those in the general Japanese population, were more often follicular in type, were associated with less female predominance, and occurred at a younger age. The increase only among Japanese may be due to a different mutational spectrum than that in whites with the syndrome.

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      A case–control study of non-Hodgkin lymphoma and exposure to pesticides (pages 1353–1360)

      Lennart Hardell and Mikael Eriksson

      Article first published online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990315)85:6<1353::AID-CNCR19>3.0.CO;2-1

      In this case–control study on non-Hodgkin lymphoma (NHL), increased risk was found for subjects exposed to herbicides and fungicides. The herbicide 4-chloro-2-methyl phenoxyacetic acid was significantly associated with NHL. For several categories of herbicides, it was noted that only exposure during the most recent decades before diagnosis of NHL was associated with an increased risk of NHL.

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      Outcome of advanced stage low grade follicular lymphomas in a population-based retrospective cohort (pages 1361–1368)

      Lori A. Wood, Robert W. Coupland, Scott A. North and Martin C. Palmer

      Article first published online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990315)85:6<1361::AID-CNCR20>3.0.CO;2-W

      To the authors' knowledge this is the first study to describe the outcome of patients with advanced stage follicular lymphoma in a population-based cohort. The median overall survival of 5.9 years offers a less positive perspective on the outcome of these patients than in previous nonpopulation-based reports.

    21. General Topic

      Calcium Channel Blocker and Cancer Risk
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      Incidence of cancer in postmyocardial infarction patients treated with short-acting nifedipine and diltiazem (pages 1369–1374)

      Ken Kanamasa, Akio Kimura, Masaru Miyataka, Toshihiko Takenaka, Kinji Ishikawa and on behalf of the Secondary Prevention Group

      Article first published online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990315)85:6<1369::AID-CNCR21>3.0.CO;2-5

      The incidence of cancer was found to be slightly higher in patients receiving nifedipine compared with patients who were not receiving a calcium antagonist, but the increase was not statistically significant.

    22. Complications of Therapy: Interferon Cardiotoxiciy
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      The effect of interferon on mouse myocardial capillaries : An ultrastructural study (pages 1375–1379)

      Hertzel Salman, Michael Bergman, Hanna Bessler, Svetlana Alexandrova and Meir Djaldetti

      Article first published online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990315)85:6<1375::AID-CNCR22>3.0.CO;2-D

      Two groups of mice treated with interferon-α-2a at a dose of 400 U per g of body weight for 3 and 5 months, respectively, showed significantly increased thickness of their myocardial capillary walls. The observed subsequent decrease in the size of the myocardial lumen may serve as one explanation for the cardiac complications observed in patients treated with interferon.

    23. Pediatric Oncology
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      Parental cigarette smoking and the risk of acute leukemia in children (pages 1380–1388)

      Jack Brondum, Xiao-Ou Shu, Michael Steinbuch, Richard K. Severson, John D. Potter and Leslie L. Robison

      Article first published online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990315)85:6<1380::AID-CNCR23>3.0.CO;2-O

      In two large case–control studies, no association was found between paternal or maternal cigarette smoking and risk of acute myeloid leukemia or acute lymphocytic leukemia in children.

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      Genomic imprinting of H19 and insulin-like growth factor-2 in pediatric germ cell tumors (pages 1389–1394)

      Julie A. Ross, Peter T. Schmidt, John P. Perentesis and Stella M. Davies

      Article first published online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990315)85:6<1389::AID-CNCR24>3.0.CO;2-V

      The authors found variable patterns of imprinting of H19 and insulin-like growth factor-2 in pediatric tumors of ovarian and extragonadal origin, whereas loss of imprinting of both genes occurred in tumors of testicular origin. This may indicate differences in the timing of carcinogenesis in germ cells at these sites.

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      Induction failure in acute lymphoblastic leukemia of childhood (pages 1395–1404)

      Lewis B. Silverman, Richard D. Gelber, Mary L. Young, Virginia Kimball Dalton, Ronald D. Barr and Stephen E. Sallan

      Article first published online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990315)85:6<1395::AID-CNCR25>3.0.CO;2-2

      There is variability regarding the precise definition of induction failure in acute lymphoblastic leukemia of childhood. The results of the current study demonstrate that patients with persistent leukemia at the end of 1 month of induction therapy have a dismal prognosis, regardless of when they subsequently achieve remission.

  2. Communication

    1. Top of page
    2. Original Article
    3. Communication
    1. General Topic

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      Frequently asked questions regarding the application of the TNM classification (pages 1405–1406)

      Leslie H. Sobin

      Article first published online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990315)85:6<1405::AID-CNCR26>3.0.CO;2-5

      This communication from the International Union Against Cancer (UICC) TNM/Prognostic Factors Project Committee answers some questions that are frequently asked on the organization's Internet TNM “helpdesk.”

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