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Cancer Cytopathology

Cover image for Cancer Cytopathology

25 April 1999

Volume 87, Issue 2

Pages 45–99

Currently known as: Cancer Cytopathology

  1. Editorial

    1. Top of page
    2. Editorial
    3. Original Article
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      Does every little cell count? Don't “ASCUS” (pages 45–47)

      Mark H. Stoler

      Article first published online: 10 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990425)87:2<45::AID-CNCR1>3.0.CO;2-J

      Atypical cells of metaplastic type are a distinct minority of atypical squamous cells of undetermined significance that are diagnostically and clinically more significant. However, all metaplastic cells are not atypical.

      See also pages 56–9.

  2. Original Article

    1. Top of page
    2. Editorial
    3. Original Article
    1. Gynecologic Cytopathology

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      Utility of liquid-based cytology for cervical carcinoma screening : Results of a population-based study conducted in a region of Costa Rica with a high incidence of cervical carcinoma (pages 48–55)

      Martha L. Hutchinson, David J. Zahniser, Mark E. Sherman, Rolando Herrero, Mario Alfaro, Maria C. Bratti, Allan Hildesheim, Attila T. Lorincz, Mitchell D. Greenberg, Jorge Morales and Mark Schiffman

      Article first published online: 10 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990425)87:2<48::AID-CNCR2>3.0.CO;2-D

      In a population-based study of over 8000 women from a high risk region of Costa Rica, liquid-based cytology demonstrated excellent sensitivity for detecting cervical carcinoma and its cytologic precursors.

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      Cytologic characteristics of abnormal cells in prior “normal” cervical/vaginal papanicolaou smears from women with a high grade squamous intraepithelial lesion (pages 56–59)

      Miguel A. Montes, Edmund S. Cibas, Sheryl A. DiNisco and Kenneth R. Lee

      Article first published online: 10 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990425)87:2<56::AID-CNCR3>3.0.CO;2-9

      Immature squamous metaplastic cells are observed in 18%, and atypical squamous metaplastic cells in 12%, of prior negative Papanicolaou smears in women with a newly diagnosed high grade squamous intraepithelial lesion.

      See also pages 45–7.

    3. Fine-Needle Aspiration

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      The use of fine-needle aspiration cytology in the molecular characterization of neuroblastoma in children (pages 60–68)

      Björn Fröstad, Tommy Martinsson, Edneia Tani, Ursula Falkmer, Catarina Darnfors, Lambert Skoog and Per Kogner

      Article first published online: 10 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990425)87:2<60::AID-CNCR4>3.0.CO;2-9

      Fine-needle aspiration (FNA) is a fast and noninvasive diagnostic technique that yields sufficient material for the molecular characterization of neuroblastic tumors by means of image cytometry and interphase fluorescent in situ hybridization. In this study, the authors examined the utility of FNA material in the molecular characterization of a group of neuroblastic tumors in children.

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      Cercariform cells : Are they specific for transitional cell carcinoma? (pages 69–74)

      Catherine A. Hida and Prabodh K. Gupta

      Article first published online: 10 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990425)87:2<69::AID-CNCR5>3.0.CO;2-Y

      The finding of numerous (>20) cercariform cells in a fine-needle aspiration (FNA) sample is significantly more likely to occur in metastatic transitional cell carcinoma than in poorly differentiated malignant epithelial neoplasms. The occurrence of a few (<20) cercariform cells is nonspecific and may be identified in FNAs from poorly differentiated malignant epithelial neoplasms from numerous sites.

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      Low grade fibromyxoid sarcoma : Fine-needle aspiration cytology with histologic, cytogenetic, immunohistochemical, and ultrastructural correlation (pages 75–82)

      Guy M. Lindberg, Anirban Maitra, S. Tunc Gokaslan, M. Hossein Saboorian and Jorge Albores-Saavedra

      Article first published online: 10 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990425)87:2<75::AID-CNCR6>3.0.CO;2-W

      The authors report the previously undescribed cytologic findings of three fine-needle aspiration biopsies of low grade fibromyxoid sarcoma, along with histologic, immunohistochemical, cytogenetic, and ultrastructural correlations.

    6. Immunocytochemistry

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      N-cadherin distinguishes pleural mesotheliomas from lung adenocarcinomas : A ThinPrep® immunocytochemical study (pages 83–86)

      Aaron C. Han, Marc R. Filstein, Jettie V. Hunt, Alejandro Peralta Soler, Karen A. Knudsen and Hernando Salazar

      Article first published online: 10 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990425)87:2<83::AID-CNCR7>3.0.CO;2-S

      N-cadherin is useful in distinguishing pleural mesotheliomas from lung adenocarcinomas by immunocytochemistry in pleural fluid specimens prepared with ThinPrep®.

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      Can keratin 8 and 17 immunohistochemistry be of diagnostic value in cervical cytology? : A feasibility study (pages 87–92)

      Jolise Martens, Janny Baars, Frank Smedts, Marjon Holterheus, Marie-Jose Kok, Peter Vooijs and Frans Ramaekers

      Article first published online: 10 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990425)87:2<87::AID-CNCR8>3.0.CO;2-L

      Staining of cervical smears with antibodies specific to keratins 8 and 17 allows for deeper insight into smear composition and may also assist in the identification of cervical intraepithelial neoplasia.

    8. Molecular Diagnostics

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      Telomerase activity in benign and malignant cytologic fluids (pages 93–99)

      Xiao C. Mu, Thomas P. Brien, Jeffrey S. Ross, Charles V. Lowry and Barbara J. McKenna

      Article first published online: 10 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990425)87:2<93::AID-CNCR9>3.0.CO;2-J

      Telomerase activity can be detected in most malignant fluid specimens but is absent in most benign fluids; thus, it shows potential as a diagnostic adjunct in fluid cytopathology.

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