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Cancer

Cover image for Cancer

15 June 1999

Volume 85, Issue 12

Pages 2497–2670

  1. Editorial

    1. Top of page
    2. Editorial
    3. Original Articles
    4. Correspondence
    1. You have free access to this content
      Soft tissue sarcoma : Opening the door to advances in diagnosis and treatment (pages 2497–2498)

      J. Sybil Biermann and Laurence H. Baker

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990615)85:12<2497::AID-CNCR1>3.0.CO;2-Y

      Our understanding of soft tissue sarcoma has previously been limited by the heterogeneity of tumors, the limitations imposed by the use of light microscopy as the sole means of diagnosis, and the lack of centralization in care. New understandings related to diagnosis and prognosis will lead to improvements in our ability to design effective treatments.

      See also pages 25967ndash;607.

  2. Original Articles

    1. Top of page
    2. Editorial
    3. Original Articles
    4. Correspondence
    1. Anatomic Site

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      The evaluation and treatment of patients receiving radiation therapy for carcinoma of the esophagus : Results of the 1992–1994 Patterns of Care Study (pages 2499–2505)

      Lawrence R. Coia, Bruce D. Minsky, Madhu J. John, Daniel G. Haller, Jerome Landry, Thomas M. Pisansky, Christopher G. Willett, John P. Hoffman, Brian A. Berkey, Jean B. Owen and Gerald E. Hanks

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990615)85:12<2499::AID-CNCR2>3.0.CO;2-T

      The U.S. national benchmarks for the evaluation and treatment of patients with esophageal carcinoma at radiation facilities are established. The majority of patients receive chemoradiation as a component of treatment.

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      Patients younger than 40 years with gastric carcinoma : Helicobacter pylori genotype and associated gastritis phenotype (pages 2506–2511)

      Massimo Rugge, Graziella Busatto, Mauro Cassaro, Yih-Horng Shiao, Valentina Russo, Gioacchino Leandro, Claudio Avellini, Alfredo Fabiano, Angelo Sidoni and Antonello Covacci

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990615)85:12<2506::AID-CNCR3>3.0.CO;2-I

      In patients younger than 40 years, Helicobacter pylori carrying the cagA gene is associated with an increased risk of both intestinal-type and diffuse-type gastric carcinoma.

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      Influence of selection criteria on mutation detection in patients with hereditary nonpolyposis colorectal cancer (pages 2512–2518)

      Karl Heinimann, Rodney J. Scott, Jean-Marie Buerstedde, Walter Weber, Karl Siebold, Michèle Attenhofer, Hansjakob Müller and Zuzana Dobbie

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990615)85:12<2512::AID-CNCR4>3.0.CO;2-G

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      Extending the Amsterdam criteria to include extracolonic tumors of the hereditary nonpolyposis colorectal cancer spectrum results in a very low mutation detection rate for the two most commonly mutated mismatch repair genes, hMSH2 and hMLH1. The findings that none of the families complying with the extended criteria harbored an unambiguous disease-causing germline mutation and that none displayed microsatellite instability suggest that these kindreds may represent an alternative genetic entity not necessarily related to DNA mismatch repair deficiency.

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      Colorectal carcinoma among ethnic Chinese in Singapore : Trends in incidence rate by anatomic subsite from 1968 to 1992 (pages 2519–2525)

      Jie Huang, Adeline Seow, Chen Yang Shi and Hin Peng Lee

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990615)85:12<2519::AID-CNCR5>3.0.CO;2-6

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      Colorectal carcinoma incidence rates have increased rapidly with no distal to proximal shift observed among Singapore Chinese between 1968 and 1992. This observation supports the role of environmental factors in the development of both proximal and distal colon carcinoma and suggests that changes in diagnostic practices observed in the West have not influenced the incidence rate of colorectal carcinoma diagnosed in Asia.

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      Serum interleukin-6 level reflects the tumor proliferative activity in patients with colorectal carcinoma (pages 2526–2531)

      Tsuneki Kinoshita, Hideki Ito and Chikao Miki

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990615)85:12<2526::AID-CNCR6>3.0.CO;2-3

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      The serum interleukin-6 concentration reflects the proliferative activity of the tumor in patients with colorectal carcinoma.

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      A multicenter evaluation of intensified, ambulatory, chronomodulated chemotherapy with oxaliplatin, 5-fluorouracil, and leucovorin as initial treatment of patients with metastatic colorectal carcinoma (pages 2532–2540)

      Francis Lévi, Rachid Zidani, Silvano Brienza, Luigi Dogliotti, Bruno Perpoint, Mathieu Rotarski, Yves Letourneau, Jean-François Llory, Philippe Chollet, Annick Le Rol, Christian Focan and International Organization for Cancer Chronotherapy

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990615)85:12<2532::AID-CNCR7>3.0.CO;2-1

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      Intensified chronotherapy with 5-fluorouracil, leucovorin, and oxaliplatin achieved a 66% objective response rate and a median survival of 18.5 months in 90 patients with previously untreated metastatic colorectal carcinoma. The figures represent improvements of 3-fold and 50%, respectively, compared with standard therapies for this disease.

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      Influence of p53 status on prognosis in preoperatively irradiated rectal carcinoma (pages 2541–2548)

      Oliver Nehls, Bodo Klump, Karlheinz Holzmann, Guido Lammering, Franz Borchard, Hans-Helmut Gruenagel, Vera Gaco, Michael Gregor and Rainer Porschen

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990615)85:12<2541::AID-CNCR8>3.0.CO;2-X

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      p53 status, evaluated by immunohistochemistry in biopsy samples taken before irradiation, was not useful in predicting the prognoses of patients with preoperatively irradiated rectal carcinoma.

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      Local recurrence after vertical partial laryngectomy, a conservative modality of treatment for patients with Stage I–II squamous cell carcinoma of the glottis (pages 2549–2556)

      Ollivier Laccourreye, Raimundo Gutierrez-Fonseca, Dominique Garcia, Stéphane Hans, Nicolas Hacquart, Madeleine Ménard and Daniel Brasnu

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990615)85:12<2549::AID-CNCR9>3.0.CO;2-M

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      The current retrospective analysis is based on an inception cohort of 103 patients who had local recurrence and a witness group of 311 patients who achieved local control during a minimum of 10 years of follow-up. In this analysis, the authors document the outcomes, treatment, and consequences of local recurrence following vertical partial laryngectomy, a conventional, conservative modality of treatment for patients with Stage I–II squamous cell carcinoma of the glottis.

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      Multiple chondromatous hamartomas of the lung : A case report and review of the literature with special reference to Carney syndrome (pages 2557–2561)

      Takuji Kiryu, Shimpei Kawaguchi, Eisuke Matsui, Hiroaki Hoshi, Mitsuharu Kokubo and Kuniyasu Shimokawa

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990615)85:12<2557::AID-CNCR10>3.0.CO;2-2

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      Some cases of multiple chondromatous hamartomas of the lung exhibit Carney syndrome. Patients with multiple chondromatous hamartomas require further examination of other sites, particularly the stomach and nervous system.

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      A phase I/II trial of neoadjuvant chemotherapy with cisplatin and vinorelbine followed by accelerated irradiation for patients with inoperable nonsmall cell lung carcinoma (pages 2562–2569)

      Jean Viallet, Marc-André Brassard, Luis Souhami, Joseph Ayoub, Pierre Del Vecchio, Harvey Kreisman, Julio Guerra, James Gruber, Adrian Langleben, John Hohneker and Pierre Rousseau

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990615)85:12<2562::AID-CNCR11>3.0.CO;2-D

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      Induction chemotherapy and accelerated radiotherapy for patients with Stage III nonsmall cell lung carcinoma is well tolerated and yields therapeutic results similar to those reported for other regimens. Clinical response to induction chemotherapy might indicate a likelihood of controlling microscopic distant metastases.

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      Thrombospondin-1 expression and clinical implications in malignant pleural mesothelioma (pages 2570–2576)

      Yasuhiko Ohta, Viji Shridhar, Gregory P. Kalemkerian, Robert K. Bright, Yoh Watanabe and Harvey I. Pass

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990615)85:12<2570::AID-CNCR12>3.0.CO;2-F

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      This study was designed to assess the impact of thrombospondin-1 (TSP-1) as a prognostic indicator in malignant pleural mesothelioma. Although TSP-1 was overexpressed in tumors and the high expression was associated with good prognosis in patients with low vascular endothelial growth factor-expressing tumors, TSP-1 itself had no overall impact on survival. The methylation status of CpG-rich regions (CpG island) associated with the TSP-1 promoter was evident in tumors despite high levels of TSP-1 expression.

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      A phase II study of gemcitabine in patients with malignant pleural mesothelioma (pages 2577–2582)

      Jan P. van Meerbeeck, Paul Baas, Channa Debruyne, Harry J. Groen, Chris Manegold, Andrea Ardizzoni, Cesare Gridelli, Eric A. van Marck, MarieAnge Lentz, Giuseppe Giaccone and European Organization for Research Treatment of Cancer Lung Cancer Cooperative Group

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990615)85:12<2577::AID-CNCR13>3.0.CO;2-S

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      Administration of gemcitabine in a commonly employed dosage and schedule for solid tumors has limited activity in chemotherapy-naive patients with malignant pleural mesothelioma.

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      Thrombotic microangiopathy associated with interferon therapy for patients with chronic myelogenous leukemia : Coincidence or true side effect? (pages 2583–2588)

      Farhad Ravandi-Kashani, Jorge Cortes, Moshe Talpaz and Hagop M. Kantarjian

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990615)85:12<2583::AID-CNCR14>3.0.CO;2-#

      Interferon therapy for patients with chronic myelogenous leukemia is associated with several well-described toxicities. Thrombotic microangiopathy is a rare side effect of interferon therapy that can lead to chronic renal failure and patient dependence on dialysis.

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      Chemotherapy for patients with locally advanced or metastatic Merkel cell carcinoma (pages 2589–2595)

      Eric Voog, Pierre Biron, Jean-Pierre Martin and Jean-Yves Blay

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990615)85:12<2589::AID-CNCR15>3.0.CO;2-F

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      A compilation of all medical records of chemotherapy for patients with locally advanced or metastatic Merkel cell carcinoma (MCC) published during the years 1980−1995 was analyzed. Chemotherapy induces high response rates among MCC patients, but the median duration of response is short after chemotherapy and overall survival is poor. A high risk of toxic death is reported.

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      Synovial sarcoma : Identification of low and high risk groups (pages 2596–2607)

      Peter Bergh, Jeanne M. Meis-Kindblom, Franco Gherlinzoni, Örjan Berlin, Patrizia Bacchini, Franco Bertoni, Björn Gunterberg and Lars-Gunnar Kindblom

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990615)85:12<2596::AID-CNCR16>3.0.CO;2-K

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      In a study of 121 patients with synovial sarcoma who had long term follow-up, low and high risk groups with overall disease free survival rates of 88% and 18%, respectively, were identified.

      See also pages 2497–8.

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      Complete regression of MX-1 human breast carcinoma xenografts after targeted chemotherapy with a cytotoxic analog of luteinizing hormone–releasing hormone, AN-207 (pages 2608–2615)

      Zsuzsanna Kahán, Attila Nagy, Andrew V. Schally, Gábor Halmos, José M. Arencibia and Kate Groot

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990615)85:12<2608::AID-CNCR17>3.0.CO;2-H

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      A cytotoxic luteinizing hormone–releasing hormone (LH-RH) analog, AN-207, can be targeted to LH-RH receptors on breast carcinomas. AN-207 caused complete regression of MX-1 hormone-independent, doxorubicin-resistant human breast carcinomas xenografted into nude mice. Targeted cytotoxic LH-RH analogs, such as AN-207, could be considered for treatment of human breast carcinomas possessing receptors for LH-RH.

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      Induction of apoptosis and suppression of clonogenicity of ovarian carcinoma cells with estrogen mustard (pages 2616–2622)

      Zhaocong Chen, Ahmed Fadiel, Ju Fang Jia, Hideki Sakamoto, Rocco Carbone and Frederick Naftolin

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990615)85:12<2616::AID-CNCR18>3.0.CO;2-J

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      Based on in vitro data, estramustine may be a promising candidate in the treatment of patients with ovarian carcinoma.

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      Epithelial ovarian carcinoma in the reproductive age group (pages 2623–2629)

      Linda R. Duska, YuChiao Chang, Cynthia E. Flynn, Annette H. Chen, Annekathryn Goodman, Arlan F. Fuller and Najmosama Nikrui

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990615)85:12<2623::AID-CNCR19>3.0.CO;2-O

      Women age ≤ 40 years with epithelial ovarian carcinoma do not have an improved prognosis compared with their postmenopausal counterparts when borderline tumors are identified correctly and eliminated from the analysis, despite often aggressive chemotherapeutic regimens. Those young women who have borderline tumors have an excellent survival rate and can be considered for fertility-sparing conservative surgery.

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      The radial distance of extraprostatic extension of prostate carcinoma : Implications for prostate brachytherapy (pages 2630–2637)

      Brian J. Davis, Thomas M. Pisansky, Torrence M. Wilson, Harold J. Rothenberg, Anna Pacelli, David W. Hillman, Daniel J. Sargent and David G. Bostwick

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990615)85:12<2630::AID-CNCR20>3.0.CO;2-L

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      In the current study, the radial distance of extraprostatic extension of prostate carcinoma was measured in 376 whole mount prostatectomy specimens. Less than 1% of cases had tumor that extended beyond 3 mm, and were well within the target volume of a typical radioactive seed implant.

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      Tumor size predicts the survival of patients with pathologic stage t2 bladder carcinoma : A critical evaluation of the depth of muscle invasion (pages 2638–2647)

      Liang Cheng, Roxann M. Neumann, Beth G. Scherer, Amy L. Weaver, Bradley C. Leibovich, Ajay Nehra, Horst Zincke and David G. Bostwick

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990615)85:12<2638::AID-CNCR21>3.0.CO;2-V

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      In the authors' view, the current subclassification of T2 cancer, based on the depth of muscle invasion, is of no practical value. Conversely, tumor size, an easily measured factor, is predictive of distant metastasis free and cancer specific survival and should be reported.

    21. General Topic

      Lymphoma: Nodal/Extranodal
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      B-lineage lymphoblastic lymphoma is a clinicopathologic entity distinct from other histologically similar aggressive lymphomas with blastic morphology (pages 2648–2654)

      Robert A. Soslow, Rebecca N. Baergen and Roger A. Warnke

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990615)85:12<2648::AID-CNCR22>3.0.CO;2-R

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      The distinction of B-lineage lymphoblastic lymphoma (B-LBL) from its histologic mimics, T-lineage lymphoblastic lymphoma (T-LBL) and the blastoid variant of mantle cell lymphoma, has important clinical implications. Patients with B-LBL present differently from those with the other very aggressive lymphomas studied, and they achieve complete remissions more often than T-LBL patients.

    22. Pediatric Oncology
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      Transient monosomy 7 : A case series in children and review of the literature (pages 2655–2661)

      Elpis Mantadakis, Kevin M. Shannon, Dale Anne Singer, Jerry Finklestein, Ka Wah Chan, Joanne M. Hilden and Eric S. Sandler

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990615)85:12<2655::AID-CNCR23>3.0.CO;2-W

      A small number of children with myelodysplastic syndromes associated with monosomy 7 or del(7q) can achieve spontaneous hematologic and cytogenetic disease remission. These data suggest that monosomy 7/del(7q) is insufficient to produce full leukemic transformation.

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      Deletion analysis of the adenomatous polyposis coli and PTCH gene loci in patients with sporadic and nevoid basal cell carcinoma syndrome-associated medulloblastoma (pages 2662–2667)

      Alexander O. Vortmeyer, Theodora Stavrou, Dena Selby, Guang Li, Robert J. Weil, Won-Sang Park, Young-Wan Moon, Roma Chandra, Alisa M. Goldstein and Zhengping Zhuang

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990615)85:12<2662::AID-CNCR24>3.0.CO;2-0

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      Morphologic examination in conjunction with genetic analysis of PTCH gene deletion in medulloblastoma tissue may prove to be a quick and efficient test with which to screen for nevoid basal cell carcinoma syndrome.

  3. Correspondence

    1. Top of page
    2. Editorial
    3. Original Articles
    4. Correspondence
    1. General Topic

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      Expression of ras, c-myc, and p53 proteins in cervical intraepithelial neoplasia (pages 2668–2669)

      Salih Marangoz and Ibrahim H. Güllü

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990615)85:12<2668::AID-CNCR25>3.0.CO;2-G

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      Author reply (page 2669)

      Betty L. Slagle, Raymond H. Kaufman, William C. Reeves and Joseph P. Icenogle

      Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990615)85:12<2669::AID-CNCR26>3.0.CO;2-A

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