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Cancer

Cover image for Cancer

1 August 1999

Volume 86, Issue 3

Pages 373–549

  1. Editorials

    1. Top of page
    2. Editorials
    3. Commentary
    4. Original Articles
    5. Communication
    6. Correspondence
    1. You have full text access to this OnlineOpen article
      Cancer and the Internet (pages 373–374)

      Donald Earl Henson

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990801)86:3<373::AID-CNCR1>3.0.CO;2-Q

      Physicians will often be confronted by patients who have misleading or inaccurate information they obtained from the Internet. A partial solution to such misleading information may depend on medical professional organizations providing information to physicians regarding reliable Internet sources and what to expect from the Internet.

      See also pages 381–90.

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      Understanding ductal carcinoma in situ : A step in the right direction (pages 375–377)

      Monica Morrow

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990801)86:3<375::AID-CNCR2>3.0.CO;2-L

      The risk of breast carcinoma–related death for women with ductal carcinoma in situ is low, regardless of histologic characteristics or method of treatment. Radiotherapy reduces the risk of disease recurrence in the breast, and awareness of the magnitude of benefit is useful in counseling patients regarding treatment.

      See also pages 429–38.

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      Parathyroid carcinoma : A diagnostic and therapeutic challenge (pages 378–380)

      Ashok R. Shaha and Jatin P. Shah

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990801)86:3<378::AID-CNCR3>3.0.CO;2-F

      Although a rare tumor, parathyroid carcinoma continues to be a difficult problem with regard to accurate diagnosis and therapeutic options.

      See also pages 538–44.

  2. Commentary

    1. Top of page
    2. Editorials
    3. Commentary
    4. Original Articles
    5. Communication
    6. Correspondence
    1. You have full text access to this OnlineOpen article
      Evaluation of cancer information on the Internet (pages 381–390)

      J. Sybil Biermann, Gregory J. Golladay, Mary Lou V. H. Greenfield and Laurence H. Baker

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990801)86:3<381::AID-CNCR4>3.0.CO;2-G

      In a review of medical information regarding a single cancer topic, the authors found abundant nonpeer-reviewed material and a 6% rate of factual inaccuracies. Therefore the authors recommend that physicians maintain an open mind regarding searches done by patients and questions raised by those searches, and suggest that physicians take an active role in identifying or creating patient information Web sites and in educating the lay public regarding variations in the quality of information and the contribution of the peer review process.

      See also pages 373–4.

  3. Original Articles

    1. Top of page
    2. Editorials
    3. Commentary
    4. Original Articles
    5. Communication
    6. Correspondence
    1. Anatomic Site

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      In colorectal carcinoma patients, serum vitamin D levels vary according to stage of the carcinoma (pages 391–397)

      Yaron Niv, Ami D. Sperber, Arie Figer, Dror Igael, Shraga Shany, Gerald Fraser and Betti Schwartz

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990801)86:3<391::AID-CNCR5>3.0.CO;2-A

      An inverse correlation between serum levels of the active metabolite of vitamin D and colorectal carcinoma stage is demonstrated. Because 1,25(OH)2D3 has been shown to inhibit the proliferation of colonic epithelial cells, decreased serum levels may facilitate the growth of colorectal carcinoma and influence its biologic behavior.

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      Preoperative radiation therapy for patients with T2–T3 carcinoma of the middle-to-lower rectum (pages 398–404)

      Federico Bozzetti, Dario Baratti, Salvatore Andreola, Roberto Zucali, Marcello Schiavo, Pasquale Spinelli, Alessandro Gronchi, Lucio Bertario, Luigi Mariani and Leandro Gennari

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990801)86:3<398::AID-CNCR6>3.0.CO;2-0

      Preoperative radiation therapy for patients with palpable rectal carcinoma that was either mobile or tethered was effective in achieving tumor regression, downstaging, and a low relapse rate at the time of a 2-year follow-up.

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      Effectiveness of surgical salvage therapy for patients with locally uncontrolled anal carcinoma after sphincter-conserving treatment (pages 405–409)

      Abdelkarim S. Allal, France M. Laurencet, Marc A. Reymond, John M. Kurtz and Marc-Claude Marti

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990801)86:3<405::AID-CNCR7>3.0.CO;2-Q

      Abdominoperineal resection continues to play an essential role in salvage therapy for patients with persistent or recurrent local disease after nonsurgical, sphincter-conserving treatment of anal carcinoma, resulting in ultimate disease control in approximately 50% of patients with isolated local failure.

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      A Phase II trial of nolatrexed dihydrochloride in patients with advanced hepatocellular carcinoma (pages 410–414)

      Keith Stuart, Judy Tessitore, Jeff Rudy, Neil Clendennin and Amanda Johnston

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990801)86:3<410::AID-CNCR8>3.0.CO;2-P

      Nolatrexed, a novel thymidylate synthase inhibitor, was evaluated in 41 patients with hepatocellular carcinoma. Modest biologic activity was noted, similar to that of other agents evaluated in Phase II studies for this poorly treatable disease. A brief review of the literature is included.

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      High dose tamoxifen plus cisplatin and etoposide in the treatment of patients with advanced, inoperable nonsmall cell lung carcinoma (pages 415–420)

      Chih-Hsin Yang, Ann-Lii Cheng, Kun-Huei Yeh, Chong-Jen Yu, Jing-Fang Lin and Pan-Chyr Yang

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990801)86:3<415::AID-CNCR9>3.0.CO;2-H

      High dose tamoxifen, cisplatin, and etoposide can be safely administered as first-line treatment to patients with advanced, inoperable nonsmall cell lung carcinoma. Favorable response rates and survival times were obtained.

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      Italian Cooperative Study for the treatment of children and young adults with localized Ewing sarcoma of bone : A preliminary report of 6 years of experience (pages 421–428)

      Pasquale Rosito, Antonia F. Mancini, Roberto Rondelli, Massimo E. Abate, Andrea Pession, Lucia Bedei, Gaetano Bacci, Piero Picci, Mario Mercuri, Pietro Ruggieri, Giampiero Frezza, Mario Campanacci and Guido Paolucci

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990801)86:3<421::AID-CNCR10>3.0.CO;2-O

      The improvement in event free survival in children and young adults with Ewing sarcoma may be due to the addition of ifosfamide and etoposide to standard chemotherapy and to the trend toward the use of more surgery than radiation therapy for local tumor control. Chemotherapy-induced tumor necrosis was found to be the most significant prognostic factor.

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      Pathologic findings from the National Surgical Adjuvant Breast Project (NSABP) eight-year update of Protocol B-17 : Intraductal carcinoma (pages 429–438)

      Edwin R. Fisher, James Dignam, Elizabeth Tan-Chiu, Joseph Costantino, Bernard Fisher, Soonmyung Paik, Norman Wolmark and for the National Surgical Adjuvant Breast Bowel Project (NSABP) Collaborating Investigators

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990801)86:3<429::AID-CNCR11>3.0.CO;2-Y

      Local breast irradiation reduced second ipsilateral breast tumors (IBT) in all pathologic subgroups of patients with intraductal carcinoma. The absolute reduction in the low risk patients was 7% at 8 years. Any decision not to administer irradiation to patients of this subset would currently appear to depend on clinical considerations and the input of informed patients.

      See also pages 375–7.

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      Intraductal spread of invasive breast carcinoma has a positive correlation with c-erb B-2 overexpression and vascular invasion (pages 439–448)

      Xuefeng Jing, Kennichi Kakudo, Maki Murakami, Yasushi Nakamura, Misa Nakamura, Toyoharu Yokoi, Qifeng Yang, Shoji Oura and Takeo Sakurai

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990801)86:3<439::AID-CNCR12>3.0.CO;2-U

      Intraductal spread of invasive carcinoma possesses an invasive and metastatic potential that is distinct from noninvasive ductal carcinoma.

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      The natural history of breast carcinoma : What have we learned from screening? (pages 449–462)

      László Tabár, Stephen W. Duffy, Bedrich Vitak, Hsiu-Hsi Chen and Teresa C. Prevost

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990801)86:3<449::AID-CNCR13>3.0.CO;2-Q

      The advent of mammographic screening has afforded the opportunity to study the natural history of breast carcinoma, particularly at an early phase in the development of the disease. The major findings are that the disease is progressive in nature and that progression is more rapid in younger women.

    10. Anatomic Site

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      Observations of prostate specific antigen doubling time in Japanese patients with nonmetastatic prostate carcinoma (pages 463–469)

      Shin Egawa, Kazumasa Matsumoto, Kazuho Suyama, Masatsugu Iwamura, Sadahito Kuwao and Shiro Baba

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990801)86:3<463::AID-CNCR14>3.0.CO;2-2

      The prostate specific antigen doubling time, calculated in 48 Japanese patients who were treated expectantly, showed a pattern similar to that reported in Western countries. However, the previously reported true incidence of clinically insignificant prostate carcinoma may have been underestimated.

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      Suramin in combination with weekly epirubicin for patients with advanced hormone-refractory prostate carcinoma (pages 470–476)

      Alfredo Falcone, Andrea Antonuzzo, Romano Danesi, Giacomo Allegrini, Lencioni Monica, Elisabetta Pfanner, Gianluca Masi, Sergio Ricci, Mario Del Tacca and Pierfranco Conte

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990801)86:3<470::AID-CNCR15>3.0.CO;2-7

      This study demonstrates the feasibility and activity of a combination of suramin and epirubicin in patients with hormone-refractory advanced prostate carcinoma, but it does not suggest major improvements compared with suramin or epirubicin alone or other available treatments.

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      Age specific risks of familial prostate carcinoma : A basis for screening recommendations in high risk populations (pages 477–483)

      Henrik Grönberg, Fredrik Wiklund and Jan-Erik Damber

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990801)86:3<477::AID-CNCR16>3.0.CO;2-K

      Men with ≥2 close relatives with prostate carcinoma have a very high risk of developing prostate carcinoma before age 70 years. These data support the screening of men from high risk families between the ages of 50–70 years, ages at which patients usually are offered curative treatment for localized disease.

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      Risk factors for prostate carcinoma in Taiwan : A case–control study in a Chinese population (pages 484–491)

      John F. C. Sung, Ruey S. Lin, Yeong-Shiau Pu, Yi-Chun Chen, Hong C. Chang and Ming-Kuen Lai

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990801)86:3<484::AID-CNCR17>3.0.CO;2-P

      A case–control study of prostate carcinoma in Taiwan suggests that vegetable intake is protective in a population with a low incidence of the disease that is in a critical socioeconomic transition period (i.e., moving from developing to nearly developed economic status). Cases also tend to be more affluent than controls, but not significantly so.

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      The detection of renal carcinoma cells in the peripheral blood with an enhanced reverse transcriptase–polymerase chain reaction assay for MN/CA9 (pages 492–497)

      James M. McKiernan, Ralph Buttyan, Neil H. Bander, Alexandre de la Taille, Michael D. Stifelman, Eric R. Emanuel, Emilia Bagiella, Mark A. Rubin, Aaron E. Katz, Carl A. Olsson and Ihor S. Sawczuk

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990801)86:3<492::AID-CNCR18>3.0.CO;2-R

      A reverse transcriptase–polymerase chain reaction assay that detects the presence of cells expressing MN/CA9 protein in RNA extracted from tissue or from peripheral blood specimens was used to assay blood specimens obtained from renal carcinoma patients and controls. The results suggested that this assay might serve as a useful adjunct in the detection and management of clear cell renal carcinoma.

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      Hemangioma of the urinary bladder (pages 498–504)

      Liang Cheng, Antonio G. Nascimento, Roxann M. Neumann, Ajay Nehra, John C. Cheville, Dharamdas M. Ramnani, Bradley C. Leibovich and David G. Bostwick

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990801)86:3<498::AID-CNCR19>3.0.CO;2-6

      Patients with hemangioma of the urinary bladder have a favorable outcome. When the lesion is small (measuring < 3 cm), biopsy and fulguration are effective. Biopsies should be avoided in young patients with large lesions and in patients with congenital hemangiomas.

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      Neurofibroma of the urinary bladder (pages 505–513)

      Liang Cheng, Bernd W. Scheithauer, Bradley C. Leibovich, Dharamdas M. Ramnani, John C. Cheville and David G. Bostwick

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990801)86:3<505::AID-CNCR20>3.0.CO;2-A

      Neurofibroma of the bladder presents early in life, is of the plexiform type with a diffuse component, and usually occurs in the setting of generalized neurofibromatosis type 1 rather than as isolated visceral neurofibromatosis. Malignant transformation did not occur in any of these four patients during a mean follow-up time of 9.6 years.

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      A Phase II study of paclitaxel and ifosfamide for patients with advanced refractory carcinoma of the urothelium (pages 514–518)

      Christopher J. Sweeney, Stephen D. Williams, David E. Finch, Richard Bihrle, Richard S. Foster, Mary Collins, Susan Fox and Bruce J. Roth

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990801)86:3<514::AID-CNCR21>3.0.CO;2-9

      Combining paclitaxel and ifosfamide for the treatment of patients with urothelial carcinoma does not result in a better response rate than either agent alone.

    18. You have full text access to this OnlineOpen article
      The impact of nutritional status on the prognoses of patients with advanced head and neck cancer (pages 519–527)

      Marian A. E. van Bokhorst-de van der Schueren, Paul A. M. van Leeuwen, Dirk J. Kuik, W. Martin C. Klop, Hans P. Sauerwein, Gordon B. Snow and Jasper J. Quak

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990801)86:3<519::AID-CNCR22>3.0.CO;2-S

      Preoperative weight loss is a negative prognostic parameter for male patients undergoing surgery for advanced head and neck cancer.

    19. General Topic

      Chemotherapy: Phase I Trial
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      A Phase I study of raltitrexed and paclitaxel given every 3 weeks to patients with solid tumors (pages 528–532)

      Everett E. Vokes, Boon C. Goh, Donna Bertucci, Nicholas J. Vogelzang, Sridhar Mani and Mark J. Ratain

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990801)86:3<528::AID-CNCR23>3.0.CO;2-R

      This Phase I study shows that raltitrexed and paclitaxel can be combined at their respective Phase II doses; neutropenia is the main dose-limiting toxicity.

    20. Metastatic Carcinoma of Uncertain Primary Site (CUPS)
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      Determining the site of the primary cancer in patients with skeletal metastasis of unknown origin : A retrospective study (pages 533–537)

      Hirohisa Katagiri, Mitsuru Takahashi, Jiro Inagaki, Hideshi Sugiura, Shigeki Ito and Hisashi Iwata

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990801)86:3<533::AID-CNCR24>3.0.CO;2-1

      In this study, the primary cancer was identified antemortem in 56 (88%) of 64 patients. Lung carcinoma was the most frequently identified primary lesion. Thoracic and abdominal computed tomography (CT) scans were useful; however, examination of the gastrointestinal tract and pelvic CT scans seldom revealed the primary lesion.

  4. Communication

    1. Top of page
    2. Editorials
    3. Commentary
    4. Original Articles
    5. Communication
    6. Correspondence
    1. General Topic

      The American College of Surgeons Commission on Cancer and the American Cancer Society
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      Two hundred eighty-six cases of parathyroid carcinoma treated in the U.S. between 1985–1995 : A National Cancer Data Base Report (pages 538–544)

      Scott A. Hundahl, Irvin D. Fleming, Amy M. Fremgen and Herman R. Menck

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990801)86:3<538::AID-CNCR25>3.0.CO;2-K

      Analysis of 286 cases of parathyroid carcinoma accessioned in the National Cancer Data Base between 1985–1990 suggests a substantial proportion of patients fail to undergo complete, en bloc surgical resection. The rarity of this condition and late intraoperative recognition tend to thwart optimal treatment.

  5. Correspondence

    1. Top of page
    2. Editorials
    3. Commentary
    4. Original Articles
    5. Communication
    6. Correspondence
    1. General Topic

      You have full text access to this OnlineOpen article
      Impact of tumor size on the clinical outcomes of patients with Robson Stage I renal cell carcinoma (pages 545–546)

      Naoki Kanomata

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990801)86:3<545::AID-CNCR26>3.0.CO;2-P

    2. You have full text access to this OnlineOpen article
      Author reply (page 546)

      Toshiaki Kinouchi and Toshihiko Kotake

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990801)86:3<546::AID-CNCR27>3.0.CO;2-J

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      Intrapleural administration of interleukin-2 for the treatment of patients with malignant pleural mesothelioma : A Phase II study (pages 546–547)

      Theodore G. Karrison and Nicholas J. Vogelzang

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990801)86:3<546::AID-CNCR28>3.0.CO;2-G

    4. General Topic

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      Author reply (page 547)

      Philippe Astoul and Christian Boutin

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990801)86:3<547::AID-CNCR29>3.0.CO;2-A

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      Expression of p53 protein and resistance to preoperative chemotherapy in locally advanced gastric carcinoma (pages 547–549)

      Mustafa Özgüroglu and Gökhan Demir

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990801)86:3<547::AID-CNCR30>3.0.CO;2-#

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      Author reply (page 549)

      Francesco Graziano and Stefano Cascinu

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990801)86:3<549::AID-CNCR31>3.0.CO;2-R

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