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Cancer

Cover image for Cancer

1 September 1999

Volume 86, Issue 5

Pages 735–903

  1. Editorials

    1. Top of page
    2. Editorials
    3. Original Articles
    4. Correspondence
    1. You have free access to this content
      What is the significance of race to prostate carcinoma? (pages 735–737)

      David G. Bostwick

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990901)86:5<735::AID-CNCR1>3.0.CO;2-R

      More prospective studies, such as that of Fowler and Bigler in this issue of Cancer, are needed to confirm and expand our understanding of racial factors related to prostate carcinoma. As these authors correctly note, differential risk has important implications for screening and early detection. Emphasis should also be placed on determining what genetic factors determine race and whether these factors are linked to the risk of prostate carcinoma.

      See also pages 836–41.

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      Giving bad news : Is there a kinder, gentler way? (pages 738–740)

      Jimmie C. Holland and Jesús Almanza

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990901)86:5<738::AID-CNCR2>3.0.CO;2-L

      Teaching communication skills in oncology is critically important to improve patient care; satisfaction, perceptions of care, and adherence to treatment all are impacted positively by good communication. Physicians benefit by a reduction of their own stress experienced in difficult interactions and in breaking bad news. Institutions will benefit from the reduction in malpractice risks.

      See also pages 887–97.

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      Hepatocellular carcinoma and coinfection with hepatitis B and C : Making a difficult situation worse (pages 741–743)

      Robert C. Kurtz

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990901)86:5<741::AID-CNCR3>3.0.CO;2-M

      Hepatitis B and C are known etiologic factors that lead to hepatocellular carcinoma. When patients are infected with both hepatotropic viruses, the cancer can present even more of a threat to survival.

      See also pages 793–8.

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      The genetic epidemiology of male breast carcinoma (pages 744–746)

      Henry T. Lynch, Patrice Watson and Steven A. Narod

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990901)86:5<744::AID-CNCR4>3.0.CO;2-G

      Male breast carcinoma shares many similar epidemiologic, genetic, diagnostic, therapeutic, and prognostic factors with breast carcinoma in women. The genetic factor most clearly associated with male breast carcinoma is the BRCA2 germ-line mutation. Other heritable mutations observed in male breast carcinoma include BRCA1, the androgen receptor gene, and the mismatch repair genes associated with Lynch syndrome.

      See also pages 821–5.

    5. Counterpoint

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      Laparoscopy : To inflate or lift? (pages 747–748)

      Robert W. Beart Jr.

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990901)86:5<747::AID-CNCR5>3.0.CO;2-A

      Peritoneal damage may not equate to changes in the incidence or patterns of tumor recurrence.

      See also pages 749–50 and 770–4.

    6. Reply to Counterpoint

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      Laparoscopy : To inflate or lift?: Reply (pages 749–750)

      Joachim Volz and Stefanie Köster

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990901)86:5<749::AID-CNCR6>3.0.CO;2-5

      See also pages 747–8 and 770–4.

    7. Counterpoint

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      Diet and breast carcinoma survival : An abundance of hope, a dearth of evidence (pages 751–753)

      James R. Marshall

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990901)86:5<751::AID-CNCR7>3.0.CO;2-7

      The report by Holmes et al. regarding diet and prognosis after diagnosis among women with breast carcinoma provides badly needed data for an important question: should dietary change be considered as a means of improving prognosis? It will be important to learn whether the evidence from this and other observational studies converges with that from two large, ongoing experiments.

      See also pages 754–5 and 826–35.

    8. Reply to Counterpoint

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      Diet and breast carcinoma survival : An abundance of hope, a dearth of evidence—Reply (pages 754–755)

      Michelle D. Holmes and Walter C. Willett

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990901)86:5<754::AID-CNCR8>3.0.CO;2-1

      See also pages 751-3 and 826-35.

  2. Original Articles

    1. Top of page
    2. Editorials
    3. Original Articles
    4. Correspondence
    1. Anatomic Site

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      Expression of the cyclin-dependent kinase inhibitor p21WAF1/CIP1 and p53 tumor suppressor in dysplastic progression and adenocarcinoma in Barrett esophagus (pages 756–763)

      Jay S. Hanas, Megan R. Lerner, Stan A. Lightfoot, Carl Raczkowski, Donald J. Kastens, Daniel J. Brackett and Russell G. Postier

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990901)86:5<756::AID-CNCR9>3.0.CO;2-X

      Expression of cyclin-dependent kinase inhibitor p21 was significantly elevated in Barrett tissue scored as indefinite or low grade for dysplasia. p53 expression did not parallel the elevation of p21 expression during these early stages. p53 and p21 expression were substantially increased in high grade dysplasia and adenocarcinoma.

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      Pretreatment staging by endoscopic ultrasonography does not predict complete response to neoadjuvant chemoradiation in patients with esophageal carcinoma (pages 764–769)

      Shawn Mallery, Malcolm DeCamp, Raphael Bueno, Steven J. Mentzer, David J. Sugarbaker, Scott J. Swanson and Jacques Van Dam

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990901)86:5<764::AID-CNCR10>3.0.CO;2-W

      Data obtained prior to the widespread use of neoadjuvant therapy documented that patients with esophageal carcinoma classified as T4 by preoperative endoscopic ultrasonography were unlikely to benefit from attempted resection. Similar results regarding the outcome of patients with endosonographically determined T4 esophageal carcinoma were not observed in the current study of patients receiving neoadjuvant chemoradiation prior to resection.

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      The influence of pneumoperitoneum used in laparoscopic surgery on an intraabdominal tumor growth (pages 770–774)

      Joachim Volz, Stefanie Köster, Zdenek Spacek and Neidhard Paweletz

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990901)86:5<770::AID-CNCR11>3.0.CO;2-3

      The CO2 pneumoperitoneum used in laparoscopic surgery provokes particular damage to the peritoneum and induces a specific intraperitoneal tumor growth.

      See also pages 747–8 and 749–50.

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      Hepatic chemoembolization combined with systemic infusion of 5-fluorouracil and bolus leucovorin for patients with metastatic colorectal carcinoma : A Southwest Oncology Group pilot trial (pages 775–781)

      Cynthia Gail Leichman, Joth R. Jacobson, Manuel Modiano, John R. Daniels, Mark M. Zalupski, James H. Doroshow, William S. Fletcher and John S. Macdonald

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990901)86:5<775::AID-CNCR12>3.0.CO;2-M

      Hepatic chemoembolization, combined with systemic infusion of 5-fluorouracil, was given to patients with liver-dominant, metastatic colorectal carcinoma in this Southwest Oncology Group pilot trial. Improvements in response rate, time to tumor progression, and survival were not observed when compared with the Group's experience with intravenous systemic therapy for patients with this disease.

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      Validation of a new classification system for curatively resected colorectal adenocarcinoma (pages 782–792)

      Ahud Sternberg, Ohn Sibirsky, David Cohen, Leslie E. Blumenson and Nicholas J. Petrelli

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990901)86:5<782::AID-CNCR13>3.0.CO;2-R

      A new four-stage classification system for curatively resected colorectal adenocarcinoma, based on venous invasion, depth of primary tumor penetration of the bowel wall, and regional lymph node status, is presented. This new classification is a superior predictor of individual prognosis, and it may serve as a guide for improved selection of patients for adjuvant systemic treatment as well as for individualized and more cost-effective postoperative follow-up.

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      Clinical significance of prior hepatitis B virus infection in patients with hepatitis C virus–related hepatocellular carcinoma (pages 793–798)

      Shoji Kubo, Shuhei Nishiguchi, Kazuhiro Hirohashi, Hiromu Tanaka, Tadashi Tsukamoto, Hiroyuki Hamba, Taichi Shuto, Takatsugu Yamamoto, Takashi Ikebe and Hiroaki Kinoshita

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990901)86:5<793::AID-CNCR14>3.0.CO;2-K

      Hepatocellular carcinomas more often develop before cirrhosis in patients with hepatitis C virus (HCV) RNA and anti–hepatitis B core antibody than in patients positive for HCV RNA alone. Prior infection with hepatitis B virus is a risk factor for poor outcome after liver resection for patients with HCV-related hepatocellular carcinoma.

      See also pages 741–3.

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      Paraneoplastic syndromes in patients with hepatocellular carcinoma in Taiwan (pages 799–804)

      Jiing-Chyuan Luo, Shinn-Jang Hwang, Jaw-Ching Wu, Chung-Pin Li, Linag-Tsai Hsiao, Chiung-Ru Lai, Jen-Huei Chiang, Wing-Yiu Lui, Full-Young Chang and Shou-Dong Lee

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990901)86:5<799::AID-CNCR15>3.0.CO;2-#

      Hepatocellular carcinoma (HCC) patients with paraneoplastic syndromes have significantly higher levels of serum α-fetoprotein, larger tumor volume, and shorter survival than those without. Patients with hepatitis B virus–related HCC have a significantly higher prevalence of paraneoplastic syndromes than those with hepatitis C virus–related HCC.

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      Multidrug resistance protein expression in chronic myeloid leukemia : Associations and significance (pages 805–813)

      Francis J. Giles, Hagop M. Kantarjian, Jorge Cortes, Deborah A. Thomas, Moshe Talpaz, Taghi Manshouri and Maher Albitar

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990901)86:5<805::AID-CNCR16>3.0.CO;2-E

      In the current study, multidrug resistance protein overexpression was noted in approximately 55% of patients, and was not associated with disease progression, responsiveness to interferon-α therapy, or survival in patients with early chronic phase chronic myeloid leukemia.

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      Are older breast carcinoma survivors willing to take hormone replacement therapy? (pages 814–820)

      Patricia A. Ganz, Gail A. Greendale, Barbara Kahn, June F. O'Leary and Katherine A. Desmond

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990901)86:5<814::AID-CNCR17>3.0.CO;2-D

      When presented with the hypothetical choice of taking hormone replacement therapy for menopausal symptoms, few older breast carcinoma survivors opted for such therapy.

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      Localized male breast carcinoma and family history : An analysis of 142 patients (pages 821–825)

      Arnold Hill, Yusuf Yagmur, Katherine N. Tran, John S. Bolton, Mark Robson and Patrick I. Borgen

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990901)86:5<821::AID-CNCR18>3.0.CO;2-I

      For men with breast carcinoma, the presence of a family history of the disease did not affect the age at presentation or the overall survival. The most powerful predictor of outcome for these men was the status of the axillary lymph nodes.

      See also pages 744–6.

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      Dietary factors and the survival of women with breast carcinoma (pages 826–835)

      Michelle D. Holmes, Meir J. Stampfer, Graham A. Colditz, Bernard Rosner, David J. Hunter and Walter C. Willett

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990901)86:5<826::AID-CNCR19>3.0.CO;2-0

      A low fat diet did not appear to confer a survival advantage after the diagnosis of breast carcinoma. Women consuming more protein, but not red meat, had an increased survival.

      See also pages 751–3 and 754–5.

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      A prospective study of the serum prostate specific antigen concentrations and gleason histologic scores of black and white men with prostate carcinoma (pages 836–841)

      Jackson E. Fowler Jr. and Steven A. Bigler

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990901)86:5<836::AID-CNCR20>3.0.CO;2-P

      The authors studied prospectively the stage specific levels of prostate specific antigen (PSA) and Gleason scores of 465 black and 331 white men consecutively, with biopsy-detected prostate carcinoma. The PSA at diagnosis was significantly higher in black men with local and regional stage cancer, and the rate of incidence of Gleason score 8–10 cancer was significantly greater among black men with local stage cancer..

      See also pages 735–7.

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      Extracapsular invasion of lymph node metastasis : A good indicator of disease recurrence and poor prognosis in patients with thyroid microcarcinoma (pages 842–849)

      Hiroto Yamashita, Shiro Noguchi, Nobuo Murakami, Masakatus Toda, Hiroyuki Yamashita, Sinya Uchino, Shin Watanabe and Hitoshi Kawamoto

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990901)86:5<842::AID-CNCR21>3.0.CO;2-X

      Lymph node metastasis accompanied by extracapsular invasion are related to disease recurrence and poorer prognosis in patients with thyroid microcarcinoma.

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      Mantle cell lymphoma in leukemic phase : Characterization of its broad cytologic spectrum with emphasis on the importance of distinction from other chronic lymphoproliferative disorders (pages 850–857)

      Kit-Fai Wong, John K. C. Chan, Jason C. C. So and Pui-Hung Yu

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990901)86:5<850::AID-CNCR22>3.0.CO;2-Z

      Mantle cell lymphoma with leukemic presentation is uncommon and is often difficult to distinguish from other chronic lymphoproliferative disorders. In this study, four cytologic patterns are identified; they are characterized by prominent nuclear irregularity and clefting, small nucleoli, moderately dense but evenly distributed chromatin, scanty cytoplasm, and the presence of multilobulated giant cells.

    15. General Topic

      Neuroendocrine Tumors
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      Chromogranin A, neuron specific enolase, carcinoembryonic antigen, and hydroxyindole acetic acid evaluation in patients with neuroendocrine tumors (pages 858–865)

      Emilio Bajetta, Leonardo Ferrari, Antonia Martinetti, Luigi Celio, Giuseppe Procopio, Salvatore Artale, Nicoletta Zilembo, Maria Di Bartolomeo, Ettore Seregni and Emilio Bombardieri

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990901)86:5<858::AID-CNCR23>3.0.CO;2-8

      This article discusses the role of biomarker measurement in patients with neuroendocrine tumors. In >100 cases, chromogranin A was shown to be the marker that represents most accurately the clinical status of patients with neuroendocrine tumors.

    16. Nutrition
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      Cutaneous bleeding related to zinc deficiency in two cases of advanced cancer (pages 866–870)

      Mario Stefanini

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990901)86:5<866::AID-CNCR24>3.0.CO;2-A

      Patients with advanced cancer may develop cutaneous hemorrhages, prolonged bleeding time, and abnormal platelet aggregation related to a deficiency of zinc. Symptoms and findings are corrected by supplementation with zinc.

    17. Pain Control in Cancer Patients
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      High dose morphine use in the hospice setting : A database survey of patient characteristics and effect on life expectancy (pages 871–877)

      Michaela Bercovitch, Alexander Waller and Abraham Adunsky

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990901)86:5<871::AID-CNCR25>3.0.CO;2-L

      Twelve percent of end-of-life cancer patients are in need of high doses of morphine. Life expectancy is not affected by this treatment.

    18. Pediatric Oncology
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      Leptomeningeal melanoma in childhood (pages 878–886)

      Guy W. J. Makin, Osborn B. Eden, Linda S. Lashford, John Moppett, Mary P. Gerrard, Helena A. Davies, Colin V. E. Powell, Alastair N. Campbell and H. Frances Child

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990901)86:5<878::AID-CNCR26>3.0.CO;2-Y

      This article describes a series of patients with leptomeningeal melanoma and reviews the literature concentrating on therapy.

    19. Psychosociology
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      Communication skills training in oncology : Description and preliminary outcomes of workshops on breaking bad news and managing patient reactions to illness (pages 887–897)

      Walter F. Baile, Andrzej P. Kudelka, Estela A. Beale, Gary A. Glober, Eric G. Myers, Anthony J. Greisinger, Robert C. Bast Jr., Michael G. Goldstein, Dennis Novack and Renato Lenzi

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990901)86:5<887::AID-CNCR27>3.0.CO;2-X

      Interactive workshops for oncologists increased their confidence in breaking bad news and in managing stressful patient encounters.

      See also pages 738–40.

  3. Correspondence

    1. Top of page
    2. Editorials
    3. Original Articles
    4. Correspondence
    1. General Topic

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      Human tumor xenografts in nude mice are not always of human origin : A warning signal (pages 898–899)

      Graziella Pratesi and Monica Tortoreto

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990901)86:5<898::AID-CNCR28>3.0.CO;2-Q

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      Author reply (pages 899–900)

      Sen Pathak, Margit A. Nemeth and Asha S. Multani

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990901)86:5<899::AID-CNCR29>3.0.CO;2-K

    3. General Topic

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    4. You have free access to this content
      Author reply (pages 902–903)

      Vittorio Franciosi and Giorgio Cocconi

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990901)86:5<902::AID-CNCR31>3.0.CO;2-X

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