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Cancer

Cover image for Cancer

1 October 1999

Volume 86, Issue 7

Pages 1099–1380

  1. Editorial

    1. Top of page
    2. Editorial
    3. Original Articles
    4. Case reports
    5. Original Articles
    6. Correspondence
    1. You have free access to this content
      5-Fluorouracil toxicity : Old or new? (pages 1099–1100)

      B. J. Kennedy

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991001)86:7<1099::AID-CNCR1>3.0.CO;2-X

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      5-fluorouracil and leucovorin-induced small intestinal ulceration and inflammation with occasional perforation but without involvement of the colon is reported as a new phenomenon. However, perhaps this may be only a limited manifestation of an older reported toxicity.

      See also pages 1129–34.

  2. Original Articles

    1. Top of page
    2. Editorial
    3. Original Articles
    4. Case reports
    5. Original Articles
    6. Correspondence
    1. Anatomic Site

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      Phase II trial of chemotherapy with 5-fluorouracil, bleomycin, epirubicin, and cisplatin for patients with locally advanced, metastatic, or recurrent undifferentiated carcinoma of the nasopharyngeal type (pages 1101–1108)

      Abdelkrim Taamma, Abdelrahim Fandi, Nacer Azli, Pierre Wibault, Nadia Chouaki, Ali Hasbini, Corinne Couteau, Jean-Pierre Armand and Esteban Cvitkovic

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991001)86:7<1101::AID-CNCR2>3.0.CO;2-R

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      A neoadjuvant or palliative 4-drug combination (5-fluourouracil, bleomycin, epirubicin, and cisplatin) was found to be active in locally advanced and metastatic undifferentiated carcinoma of the nasopharynx.

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      Phase II clinical trial of SKI-2053R, a new platinum analog, in the treatment of patients with advanced gastric adenocarcinoma (pages 1109–1115)

      Noe K. Kim, Seock-Ah Im, Dong-Wan Kim, Moon H. Lee, Chul W. Jung, Eun K. Cho, Jong T. Lee, Jin S. Ahn, Dae S. Heo and Yung-Jue Bang

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991001)86:7<1109::AID-CNCR3>3.0.CO;2-G

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      SKI-2053R, a new platinum analog, was active in the treatment of gastric adenocarcinoma and had favorable toxicity profiles.

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      Evaluation of a selective screening for colorectal carcinoma : The Taiwan Multicenter Cancer Screening (TAMCAS) project (pages 1116–1128)

      Tony Hsiu-Hsi Chen, Ming-Fang Yen, Mei-Shu Lai, Shin-Lan Koong, Cheng-Yi Wang, Jau-Min Wong, Teresa C. Prevost and Stephen W. Duffy

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991001)86:7<1116::AID-CNCR4>3.0.CO;2-D

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      Colorectal carcinoma screening of a high risk population is efficacious in reducing mortality and cost-effective for countries with intermediate or low incidence of the disease.

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      5-Fluorouracil-induced small bowel toxicity in patients with colorectal carcinoma (pages 1129–1134)

      Farid Fata, Ilan G. Ron, Nancy Kemeny, Eileen O'Reilly, David Klimstra and David P. Kelsen

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991001)86:7<1129::AID-CNCR5>3.0.CO;2-4

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      5-fluorouracil (5-FU) is a commonly administered chemotherapy agent that has been associated infrequently with vasospasm. In the current study the authors report an acute toxicity of small bowel damage with a normal colon in six patients treated with 5-FU.

      See also pages 1099–100.

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      The role of cysteine and serine proteases in colorectal carcinoma (pages 1135–1142)

      Làszlò Herszènyi, Mario Plebani, Paolo Carraro, Massimo De Paoli, Giovanni Roveroni, Romilda Cardin, Zsolt Tulassay, Remo Naccarato and Fabio Farinati

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991001)86:7<1135::AID-CNCR6>3.0.CO;2-2

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      Tissue cysteine proteases, cathepsin B and cathespin L (CATL), urokinase-type plasminogen activator (UPA) and tissue-type plasminogen activator, both serine proteases, and their inhibitor type-1 (PAI-1) are involved in colorectal tumor biology and in the processes of invasion and metastasis. Together with Dukes stage, determination of CATL, UPA, and PAI-1 have a major prognostic impact in colorectal carcinoma.

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      Age, gender, and local geographic variations of viral etiology of hepatocellular carcinoma in a hyperendemic area for hepatitis B virus infection (pages 1143–1150)

      Chuan-Mo Lee, Sheng-Nan Lu, Chi-Sin Changchien, Chau-Ting Yeh, Tsung-Teng Hsu, Jui-Hsiang Tang, Jing-Houng Wang, Deng-Yn Lin, Chao-Long Chen and Wei-Jen Chen

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991001)86:7<1143::AID-CNCR7>3.0.CO;2-Z

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      In this study, the mean age and gender ratio were found to vary for patients with hepatocellular carcinoma depending on viral etiology. An area in which hepatitis C virus-related hepatocellular carcinoma was prevalent was identified in a region to which hepatitis B virus was endemic.

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      Should hepatomas be treated with hepatic resection or transplantation? (pages 1151–1158)

      Junji Yamamoto, Shunzaburo Iwatsuki, Tomoo Kosuge, Igor Dvorchik, Kazuaki Shimada, J. Wallis Marsh, Susumu Yamasaki and Thomas E. Starzl

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991001)86:7<1151::AID-CNCR8>3.0.CO;2-V

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      In the face of donor shortage, hepatocellular carcinoma developing in a well compensated cirrhotic liver initially may be treated with hepatic resection. Transplantation should be applied selectively to those patients with tumor recurrence and/or progressive hepatic failure.

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      Frequency of noncontiguous lymph node involvement in patients with resectable nonsmall cell lung carcinoma (pages 1159–1164)

      James A. Bonner, Yolanda I. Garces, Timothy E. Sawyer, Perry M. Gould, Robert L. Foote, Claude Deschamps, Carla M. Lange and Hongzhe Li

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991001)86:7<1159::AID-CNCR9>3.0.CO;2-K

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      Noncontiguous involvement of thoracic lymph nodes was found in approximately 15% of patients who had complete surgical resection of nonsmall cell lung carcinoma. This suggests that lack of involvement of N1 lymph nodes does not rule out mediastinal involvement.

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      Clinical features of patients with stage IIIB and IV bronchioloalveolar carcinoma of the lung (pages 1165–1173)

      Oscar S. Breathnach, Naoko Ishibe, John Williams, R. Ilona Linnoila, Neil Caporaso and Bruce E. Johnson

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991001)86:7<1165::AID-CNCR10>3.0.CO;2-9

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      Patients with advanced bronchioloalveolar carcinoma of the lung are more likely to have bilateral pulmonary involvement, are less likely to develop brain metastases, and have longer survival than patients with other forms of advanced nonsmall cell lung carcinoma.

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      Expression of proliferating cell nuclear antigen and CD44 variant isoforms in the primary and metastatic sites of nonsmall cell lung carcinoma with intrapulmonary metastases (pages 1174–1181)

      Tatsuo Fukuse, Toshiki Hirata, Hironobu Naiki, Shigeki Hitomi and Hiromi Wada

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991001)86:7<1174::AID-CNCR11>3.0.CO;2-8

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      In the current study, expression of proliferating cell nuclear antigen was found to be a significant prognostic factor for both primary and metastatic lesions in patients with intrapulmonary metastases. CD44 variant exon 6 (CD44v6) showed histogenesis of the tumor, but no relation with the prognosis could be ascertained.

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      Histologic types of lung carcinoma and related family history of anatomic sites and histologic types of cancers (pages 1182–1188)

      Hideo Kunitoh, Ikuo Sekine, Kaoru Kubota, Tomohide Tamura, Tetsu Shinkai, Tetsuro Kodama, Nagahiro Saijo, Tsuguo Naruke and Naohito Yamaguchi

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991001)86:7<1182::AID-CNCR12>3.0.CO;2-A

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      An association between familial factors and histologic type of lung carcinoma has been suggested. Genetic factors that may determine individual susceptibility to lung carcinogenesis should be investigated according to each histologic type.

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      Induction chemotherapy employing dose-intense cisplatin with mitomycin and vinblastine (MVP400), followed by thoracic surgery or irradiation, for patients with stage III nonsmall cell lung carcinoma (pages 1189–1197)

      Kenneth K. Ng, Mark G. Kris, Robert J. Ginsberg, Robert T. Heelan, Katherine M. W. Pisters, Vincent A. Miller, Stefan C. Grant, Manjit Bains, Valerie Rusch, Kenneth E. Rosenzweig and Nael Martini

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991001)86:7<1189::AID-CNCR13>3.0.CO;2-N

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      Dose-intense MVP400 had no advantage over MVP before surgery or irradiation for patients with locally advanced nonsmall cell lung carcinoma. The authors continue to recommend MVP as an induction chemotherapy regimen for clinical trials.

  3. Case reports

    1. Top of page
    2. Editorial
    3. Original Articles
    4. Case reports
    5. Original Articles
    6. Correspondence
    1. Anatomic Site

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      Sacrococcygeal teratoma in adults : Case reports and a review of the literature (pages 1198–1202)

      Elizabeth W. Ng, Pierluigi Porcu and Patrick J. Loehrer Sr.

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991001)86:7<1198::AID-CNCR14>3.0.CO;2-M

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      Sacrococcygeal teratoma is rare in adults but should be included in the differential diagnosis of pelvic tumors. Long term survival can be achieved with adequate surgical excision.

  4. Original Articles

    1. Top of page
    2. Editorial
    3. Original Articles
    4. Case reports
    5. Original Articles
    6. Correspondence
    1. Anatomic Site

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      Combination therapy with methotrexate, vincristine, polyethylene-glycol conjugated-asparaginase, and prednisone in the treatment of patients with refractory or recurrent acute lymphoblastic leukemia (pages 1203–1209)

      Alvaro Aguayo, Jorge Cortes, Deborah Thomas, Sherry Pierce, Michael Keating and Hagop Kantarjian

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991001)86:7<1203::AID-CNCR15>3.0.CO;2-3

      L-asparaginase in combination with methotrexate has synergistic antileukemia activity in patients with acute lymphoblastic leukemia (ALL). A new formulation of L-asparaginase, polyethylene-glycol conjugated (PEG)-asparaginase, has a longer half-life and is less immunogenic. A combination of methotrexate, vincristine, PEG-asparaginase, and prednisone was used to treat 32 patients with refractory or recurrent ALL. Seven patients (22%) achieved a complete remission (CR). The median duration of the CR was 16 weeks and the median survival of the patients was 12 weeks.

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      Herpes lymphadenitis in association with chronic lymphocytic leukemia (pages 1210–1215)

      John P. T. Higgins and Roger A. Warnke

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991001)86:7<1210::AID-CNCR16>3.0.CO;2-8

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      Herpes lymphadenitis may be seen in association with chronic lymphocytic leukemia. The infection may follow an indolent course even if untreated.

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      Primary refractory and relapsed adult acute lymphoblastic leukemia : Characteristics, treatment results, and prognosis with salvage therapy (pages 1216–1230)

      Deborah A. Thomas, Hagop Kantarjian, Terry L. Smith, Charles Koller, Jorge Cortes, Susan O'Brien, Francis J. Giles, James Gajewski, Sherry Pierce and Michael J. Keating

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991001)86:7<1216::AID-CNCR17>3.0.CO;2-O

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      A review of 314 patients treated for relapsed or refractory acute lymphoblastic leukemia identified factors associated with poor outcomes: older age, short duration of first complete response, and circulating blasts. Despite favorable responses in some subgroups, the overall results with therapy were uniformly poor, highlighting the need to identify strategies to improve first remission duration and the need for further research of new agents.

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      Severe adverse impact on sexual functioning and fertility of bone marrow transplantation, either allogeneic or autologous, compared with consolidation chemotherapy alone : Analysis of the MRC AML 10 trial (pages 1231–1239)

      Maggie Watson, Keith Wheatley, Georgina A. Harrison, Robert Zittoun, Richard G. Gray, Alan H. Goldstone and Alan K. Burnett

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991001)86:7<1231::AID-CNCR18>3.0.CO;2-Y

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      Data from the current study showed that bone marrow transplantation (BMT) had an adverse impact on sexual health and fertility compared with consolidation chemotherapy (CCT) in patients with acute myeloid leukemia (AML) who were included in the AML 10 trial. These aspects of quality of life were assessed ≥1 year after the completion of therapy in patients whose disease remained in remission. Because the survival benefits of BMT over CCT are quite modest, these iatrogenic effects should be considered when deciding on appropriate treatment for leukemia and follow-up management for patients whose AML is in first complete remission.

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      Increased risk of lymphoid and nonlymphoid malignancies in patients with lymphomatoid papulosis (pages 1240–1245)

      Helen H. Wang, Timothy Myers, Lori J. Lach, Chung-cheng Hsieh and Marshall E. Kadin

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991001)86:7<1240::AID-CNCR19>3.0.CO;2-X

      Patients with lymphomatoid papulosis were found to have an increased risk for both lymphoid and nonlymphoid malignancies.

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      Chromosome rearrangement at 17q25 and Xp11.2 in alveolar soft-part sarcoma : A case report and review of the literature (pages 1246–1250)

      Susumu Joyama, Takafumi Ueda, Kiichi Shimizu, Ikuo Kudawara, Masayuki Mano, Hiroko Funai, Koichi Takemura and Hideki Yoshikawa

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991001)86:7<1246::AID-CNCR20>3.0.CO;2-4

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      This case report documents a clonal chromosome abnormality of der(17)t(X;17)(p11.2;q25) in alveolar soft-part sarcoma (ASPS), suggesting that further molecular analyses focused on 17q25 and Xp11.2 are of interest and could help to elucidate the pathogenesis of ASPS.

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      Phase II study of vinorelbine administered by 96-hour infusion in patients with advanced breast carcinoma (pages 1251–1257)

      Nuhad K. Ibrahim, Zia Rahman, Vicente Valero, Jie Willey, Richard L. Theriault, Aman U. Buzdar, James L. Murray III, Robert Bast and Gabriel N. Hortobagyi

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991001)86:7<1251::AID-CNCR21>3.0.CO;2-F

      Due to toxicity, a revised maximum tolerated dose for continuous infusion vinorelbine is proposed. The current dosing schedule did not offer an advantage in either response rates or survival compared with the weekly vinorelbine bolus injection in doxorubicin-resistant and paclitaxel-resistant patients.

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      Significance of axillary lymph node extranodal soft tissue extension and indications for postmastectomy irradiation (pages 1258–1262)

      John E. Mignano, Marianna L. Zahurak, Anuradha Chakravarthy, Steven Piantadosi, William C. Dooley and Irene Gage

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991001)86:7<1258::AID-CNCR22>3.0.CO;2-S

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      Axillary lymph node extranodal soft tissue extension does not appear to correlate with an increased risk of axillary recurrence, even without axillary irradiation.

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      P-cadherin expression in breast carcinoma indicates poor survival (pages 1263–1272)

      Alejandro Peralta Soler, Karen A. Knudsen, Hernando Salazar, Aaron C. Han and Albert A. Keshgegian

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991001)86:7<1263::AID-CNCR23>3.0.CO;2-2

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      The expression of cadherin and catenin cell-cell adhesion proteins was analyzed in 183 paraffin embedded breast carcinoma tissue sections by immunohistochemistry. The expression of P-cadherin was found to correlate with poor survival of patients.

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      Malignant melanoma of the vulva in a nationwide, 25-year study of 219 Swedish females : Clinical observations and histopathologic features (pages 1273–1284)

      Boel K. Ragnarsson-Olding, Lena R. Kanter-Lewensohn, Bengt Lagerlöf, Bo R. Nilsson and Ulrik K. Ringborg

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991001)86:7<1273::AID-CNCR24>3.0.CO;2-Z

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      To the authors' knowledge, this report encompasses the largest series of vulvar melanomas published. It highlights the clinical and histopathologic features that are at variance with cutaneous melanoma, and shows differences among tumors in various compartments of the vulva.

      See also pages 1273–84.

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      Malignant melanoma of the vulva in a nationwide, 25-year study of 219 Swedish females : Predictors of survival (pages 1285–1293)

      Boel K. Ragnarsson-Olding, Bo R. Nilsson, Lena R. Kanter-Lewensohn, Bengt Lagerlöf and Ulrik K. Ringborg

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991001)86:7<1285::AID-CNCR25>3.0.CO;2-P

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      Tumor thickness, ulceration, and macroscopic amelanosis, but not treatment mode, were identified as the most important predictors of tumor specific survival.

      See also pages 1273–84.

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      Allelic loss on chromosome 1 is associated with tumor progression of cervical carcinoma (pages 1294–1298)

      Tak Hong Cheung, Tony Kwok Hung Chung, Cho Sun Poon, Garrett M. Hampton, Vivian W. Wang and Yick Fu Wong

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991001)86:7<1294::AID-CNCR26>3.0.CO;2-O

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      Frequent loss of heterozygosity (LOH) on chromosome 1 is observed in cervical carcinoma. This suggests that inactivation of tumor suppressor genes is important in the tumorigenesis of this disease. Significantly higher frequencies of LOH found in Stage III and IV disease compared with Stage I and II suggest that these chromosomal changes are late events related to tumor progression.

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      Characterization of Type I collagen synthesis and maturation in uterine carcinosarcomas (pages 1299–1306)

      Saila Kauppila, Frej Stenbäck, Barry M. Kacinski, Maria-Luisa Carcangiu, Juha Risteli and Leila Risteli

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991001)86:7<1299::AID-CNCR27>3.0.CO;2-6

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      Type I (pro)collagen synthesis and corresponding protein maturation were studied in uterine carcinosarcomas by in situ hybridization and immunohistochemistry. The undifferentiated cells of uterine carcinosarcomas are capable of producing their own stroma with irregularly arranged collagen bundles.

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      Chemosensitivity and p53-dependent apoptosis in epithelial ovarian carcinoma (pages 1307–1313)

      Shinya Sato, Junzo Kigawa, Yukihisa Minagawa, Makoto Okada, Muneaki Shimada, Masakuni Takahashi, Shunji Kamazawa and Naoki Terakawa

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991001)86:7<1307::AID-CNCR28>3.0.CO;2-F

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      p53-dependent apoptosis in tumors is strongly related to chemosensitivity in epithelial ovarian carcinoma.

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      The age of the urologist affects the postoperative care of prostate carcinoma patients (pages 1314–1321)

      Diana Y. Tsai, Katherine S. Virgo, John W. Colberg, David K. Ornstein, Eric T. Johnson, Danny Chan and Frank E. Johnson

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991001)86:7<1314::AID-CNCR29>3.0.CO;2-K

      Patient management strategies utilized by urologists caring for prostate carcinoma patients after radical prostatectomy vary appreciably. A survey of urologists was used to determine the reasons for variation in practices. The age of the practitioner was found to have a significant effect on the management of at-risk patients, although the effect was small.

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      Hypoxic radiosensitizers in radical radiotherapy for patients with bladder carcinoma : Hyperbaric oxygen, misonidazole, and accelerated radiotherapy, carbogen, and nicotinamide (pages 1322–1328)

      Peter J. Hoskin, Michelle I. Saunders and Stanley Dische

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991001)86:7<1322::AID-CNCR30>3.0.CO;2-E

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      Sequential cohorts of patients treated with radical radiotherapy for bladder carcinoma using attempts at hypoxia modification were analyzed. The current approach using accelerated radiotherapy, carbogen, and nicotinamide has high local control rates compared with previous experience with no increase in morbidity. The authors propose Phase III trials to test this approach further.

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      A phase II trial of methotrexate, cisplatin, 5-fluorouracil, and leucovorin in the treatment of invasive and metastatic urothelial carcinoma (pages 1329–1334)

      William K. Oh, Judith Manola, Jerome P. Richie, Kevin R. Loughlin and Philip W. Kantoff

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991001)86:7<1329::AID-CNCR31>3.0.CO;2-R

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      In the current study the treatment of muscle invasive or metastatic urothelial carcinoma with methotrexate, cisplatin, 5-fluorouracil, and leucovorin was found to be associated with a 63% response rate and moderate toxicity.

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      KDR activation in astrocytic neoplasms (pages 1335–1341)

      Rona S. Carroll, Jianping Zhang, Lorenzo Bello, Michael B. Melnick, Taka Maruyama and Peter McL Black

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991001)86:7<1335::AID-CNCR32>3.0.CO;2-Z

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      In this study the authors determined the activation state of the vascular endothelial growth factor receptor, KDR, in all grades of astrocytic neoplasms using an antibody that recognizes the phosphorylation state of tyrosines 1054/1059 in the receptor. Immunoblotting with this antibody shows that the receptor is phosphorylated constitutively within multiple fresh surgical specimens of glioblastomas (70%) and anaplastic gliomas (15%), but not in low grade gliomas. This strongly supports the hypothesis that the onset of angiogenesis is an important event during disease progression in gliomas.

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      Significantly lower incidence of cancer among patients with Huntington disease : An apoptotic effect of an expanded polyglutamine tract? (pages 1342–1346)

      S. Asger Sørensen, Kirsten Fenger and Jørgen H. Olsen

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991001)86:7<1342::AID-CNCR33>3.0.CO;2-3

      The incidence of cancer was significantly lower among 694 patients with Huntington disease (HD) compared with 695 healthy relatives and population estimates. The authors of this study hypothesize that this was due to an apoptotic effect of the expanded polyglutamine tract in the protein encoded by the HD gene.

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      Survival of patients with high grade glioma treated with intrathecal thiotriethylenephosphoramide for ependymal or leptomeningeal gliomatosis (pages 1347–1353)

      Timothy F. Witham, Melanie B. Fukui, Carolyn Cidis Meltzer, Richard Burns, Douglas Kondziolka and Michael E. Bozik

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991001)86:7<1347::AID-CNCR34>3.0.CO;2-M

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      The available literature regarding the use of intrathecal chemotherapy for the treatment of patients with ependymal or leptomeningeal extension of malignant glioma is scant. Intrathecal therapy with thiotriethylenephosphoramide delivered via a ventricular reservoir system should be considered when patients with malignant glioma present with ependymal or leptomeningeal extension.

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      Tissue factor expressed in pituitary adenoma cells contributes to the development of vascular events in pituitary adenomas (pages 1354–1361)

      Toru Nishi, Tomoaki Goto, Hideo Takeshima, Kazuya Hamada, Kenji Tada, Yoshiki Saito, Masato Kochi, Jun-ichi Kuratsu and Yukitaka Ushio

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991001)86:7<1354::AID-CNCR35>3.0.CO;2-R

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      Overexpression of tissue factor by pituitary adenoma cells may contribute to the development of vascular events, such as infarction and/or hemorrhagic infarction, in pituitary adenomas.

    22. General Topic

      Anemia: Erythropoietin
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      Erythropoietin reduces anemia and transfusions : A randomized trial with or without erythropoietin during chemotherapy (pages 1362–1367)

      Frank R. Dunphy, Bruce R. Harrison, Teresa L. Dunleavy, Jack J. Rodriguez, Jack G. Hilton and James H. Boyd

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991001)86:7<1362::AID-CNCR36>3.0.CO;2-T

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      There was less anemia and fewer transfusions in patients randomized to receive erythropoietin during chemotherapy with paclitaxel and carboplatin.

    23. Lymphoma, Cutaneous
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      Chemotherapy with etoposide, vincristine, doxorubicin, bolus cyclophosphamide, and oral prednisone in patients with refractory cutaneous T-cell lymphoma (pages 1368–1376)

      Gorgun Akpek, Howard K. Koh, Steven Bogen, Carl O'Hara and Francine M. Foss

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991001)86:7<1368::AID-CNCR37>3.0.CO;2-8

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      Alternative treatment modalities are needed in patients with advanced cutaneous T-cell lymphoma (CTCL) including mycosis fungoides. In this study, combination chemotherapy with etoposide, vincristine, doxorubicin, bolus cyclophosphamide, and oral prednisone was found to be an effective treatment regimen in patients with recurrent and refractory CTCL.

  5. Correspondence

    1. Top of page
    2. Editorial
    3. Original Articles
    4. Case reports
    5. Original Articles
    6. Correspondence
    1. General Topic

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      Prospective study of the value of serum chromogranin A or serum gastrin levels in the assessment of the presence, extent, or growth of gastrinomas (pages 1377–1378)

      Helge L. Waldum and Unni Syversen

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991001)86:7<1377::AID-CNCR38>3.0.CO;2-7

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      Author reply (pages 1378–1379)

      Stephan U. Goebel, Jose Serrano and Robert T. Jensen

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991001)86:7<1378::AID-CNCR39>3.0.CO;2-1

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      Erratum (page 1380)

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991001)86:7<1380::AID-CNCR40>3.0.CO;2-D

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