You have free access to this content

Cancer

Cover image for Cancer

15 December 1999

Volume 86, Issue 12

Pages 2589–2708

  1. Editorial

    1. Top of page
    2. Editorial
    3. Original Articles
    4. Communications
    5. Erratum
    1. You have free access to this content
      Minimal solid tumor involvement of regional and distant sites : When is a metastasis not a metastasis? (pages 2589–2592)

      David L. Page, Thomas J. Anderson and Beverley A. Carter

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991215)86:12<2589::AID-CNCR1>3.0.CO;2-7

      Immunohistochemistry and other special techniques have been reported to be able to identify carcinoma cells in metastatic sites in which they had not been detected by conventional histology. However, many pathologists order the histochemistry before examing the hematoxylin and eosin (H&E) preparations. Thus there is truly a need for a set of guidelines regarding the size and site of metastatic deposits, as well as further research to determine the clinical significance of minute metastases not detectable with H&E preparations.

      See also pages 2668–73.

    2. You have free access to this content
      The ongoing evolution of dendritic cell therapy (pages 2593–2596)

      Mitchell H. Sokoloff and Nicholas Vogelzang

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991215)86:12<2593::AID-CNCR2>3.0.CO;2-7

      Dendritic cell therapy reflects our increased familiarity and comfort with immune-based therapies. Nonetheless, several fundamental issues need to be addressed. Until these concerns are resolved, it will be difficult for scientists and physicians, as well as the lay public, to understand fully the strength and applicability of this therapeutic approach.

      See also pages 2674–83.

  2. Original Articles

    1. Top of page
    2. Editorial
    3. Original Articles
    4. Communications
    5. Erratum
    1. Anatomic Site

      You have free access to this content
      Expression of cyclin E in dysplasia, carcinoma, and nonmalignant lesions of barrett esophagus (pages 2597–2601)

      Mario Sarbia, Nuran Bektas, Wolfram Müller, Hansjörg Heep, Franz Borchard and Helmut E. Gabbert

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991215)86:12<2597::AID-CNCR3>3.0.CO;2-0

      • original image

      Nuclear accumulation of cyclin E can be found by means of immunohistochemistry in premalignant and malignant lesions in Barrett esophagus as well as in regenerative metaplastic epithelium.

    2. You have free access to this content
      Larger and more invasive colorectal carcinoma contains larger amounts of plasminogen activator inhibitor type 1 and its relative ratio over urokinase receptor correlates well with tumor size (pages 2602–2611)

      Jinro Abe, Tetsumei Urano, Hiroyuki Konno, Yamaç Erhan, Tatsuo Tanaka, Nobuhiko Nishino, Akikazu Takada and Satoshi Nakamura

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991215)86:12<2602::AID-CNCR4>3.0.CO;2-S

      • original image
      • original image
      • original image
      • original image
      • original image
      • original image
      • original image

      Factors in plasminogen activation were assayed in 100 colorectal carcinoma tissues. Higher expression of urokinase plasminogen activator receptor (uPAR) was related to poor prognosis in patients with colorectal carcinoma and the calculated ratios of plasminogen activator type 1 over either uPAR or uPAR-bound urokinase-type plasminogen activator correlated positively with tumor size.

    3. You have free access to this content
      Chemoradiation with or without intraoperative radiation therapy in patients with locally recurrent rectal carcinoma : Prognostic factors and long term outcome (pages 2612–2624)

      Vincenzo Valentini, Alessio G. Morganti, Antonio De Franco, Claudio Coco, Carlo Ratto, GianBattista Doglietto, Lucio Trodella, Luigi Ziccarelli, Aurelio Picciocchi and Numa Cellini

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991215)86:12<2612::AID-CNCR5>3.0.CO;2-M

      • original image
      • original image
      • original image
      • original image
      • original image

      Forty-seven patients with locally recurrent rectal carcinoma were enrolled in a prospective trial of preoperative chemoradiation plus surgery with or without intraoperative radiation therapy (IORT) plus postoperative adjuvant chemotherapy. Radical resection and the extent of pelvic walls involvement (using a computed tomography-based classification system) significantly predicted clinical outcome. Patients treated with IORT boost showed high 5-year local control and survival rates (79% and 41%, respectively).

    4. You have free access to this content
      Pyloric gland metaplasia with perineural invasion of the gallbladder : A lesion that can be confused with adenocarcinoma (pages 2625–2631)

      Jorge Albores-Saavedra and Donald E. Henson

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991215)86:12<2625::AID-CNCR6>3.0.CO;2-D

      • original image
      • original image
      • original image
      • original image
      • original image

      Four cases of gallbladder pyloric gland metaplasia with perineural and intraneural invasion are reported. Histologic features that are useful to distinguish this lesion from adenocarcinoma are provided.

    5. You have free access to this content
      Chronic myelogenous leukemia in nonlymphoid blastic phase : Analysis of the results of first salvage therapy with three different treatment approaches for 162 patients (pages 2632–2641)

      Stefano Sacchi, Hagop M. Kantarjian, Susan O'Brien, Jorge Cortes, Mary Beth Rios, Francis J. Giles, Miloslav Beran, Charles A. Koller, Michael J. Keating and Moshe Talpaz

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991215)86:12<2632::AID-CNCR7>3.0.CO;2-A

      • original image
      • original image
      • original image

      Patients with chronic myelogenous leukemia in blastic phase were evaluated in relation to their first blastic therapy. Decitabine was found to be as effective and less toxic than high dose cytarabine regimens. It was associated with a survival advantage among responding patients by landmark analysis and was an independent, treatment-associated, favorable prognostic factor for patient survival by multivariate analysis.

    6. You have free access to this content
      Alternative medicine use in patients with localized prostate carcinoma treated with curative intent (pages 2642–2648)

      Marguerite C. Lippert, Rebecca McClain, James C. Boyd and Dan Theodorescu

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991215)86:12<2642::AID-CNCR8>3.0.CO;2-4

      • original image
      • original image

      The prevalence of alternative medicine use in patients with localized prostate carcinoma treated with curative intent was 43%. No significant differences in alternative medicine use were observed among various treatment modalities, but higher pretreatment tumor grades were associated with a greater use of alternative medicine.

    7. You have free access to this content
      Expression of β1 and β4 integrins in normal arachnoid membrane and meningiomas (pages 2649–2658)

      Isabelle Beschet, Jacques Brunon, Jean-Yves Scoazec and Jean-François Mosnier

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991215)86:12<2649::AID-CNCR9>3.0.CO;2-V

      • original image
      • original image
      • original image
      • original image
      • original image
      • original image
      • original image
      • original image
      • original image

      Meningiomas have a specific spectrum of expression of α, β1, and β4 integrin subunits that differ according to their histological subtype. The loss of expression of α3 and α6 integrin subunits may have prognostic value in the assessment of meningiomas.

    8. You have free access to this content
      A single-visit cervical carcinoma prevention program offered at an inner city church : A pilot project (pages 2659–2667)

      Christine H. Holschneider, Juan C. Felix, Wendy Satmary, Michael T. Johnson, Lynn M. Sandweiss and F. J. Montz

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991215)86:12<2659::AID-CNCR10>3.0.CO;2-S

      • original image

      A single-visit cervical carcinoma prevention program, integrating screening, diagnosis, treatment, and health education in the familiar environment of the community parish, was feasible and provided care to a substantial number of underserved patients.

  3. Communications

    1. Top of page
    2. Editorial
    3. Original Articles
    4. Communications
    5. Erratum
    1. Anatomic Site

      You have free access to this content
      Classification of isolated tumor cells and micrometastasis (pages 2668–2673)

      Paul Hermanek, Robert V. P. Hutter, Leslie H. Sobin and Christian Wittekind

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991215)86:12<2668::AID-CNCR11>3.0.CO;2-R

      This communication presents optional proposals for the classification of isolated tumor cells (in regional lymph nodes, etc.), micrometastasis, and cytologic findings in pleural and peritoneal washings.

    2. You have free access to this content
      Report from the International Union Against Cancer (UICC) Tumor Biology Committee : UICC workshop on the use of dendritic cells in cancer clinical trials (pages 2674–2683)

      Michael L. Salgaller, Martin Thurnher, Georg Bartsch, Alton L. Boynton and Gerald P. Murphy

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991215)86:12<2674::AID-CNCR12>3.0.CO;2-Z

      At this workshop, clinicians active in the use of dendritic cells all expressed the need to have an available supply of interleukin (IL)-4. There was discussion that unless some institution, such as the National Cancer Institute of the U.S., took action, a stable commercial source of IL-4 might not be available in the future. The UICC leadership is currently looking into this matter.

      See also pages 2593–6.

    3. You have free access to this content
      The National Cancer Data Base Report on age, gender, treatment, and outcomes of patients with chronic lymphocytic leukemia (pages 2684–2692)

      Louis F. Diehl, Lucy Hynds Karnell and Herman R. Menck

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991215)86:12<2684::AID-CNCR13>3.0.CO;2-V

      • original image
      • original image
      • original image
      • original image
      • original image
      • original image
      • original image

      Data from patients diagnosed with chronic lymphocytic leukemia (CLL) between 1985 and 1995 were extracted from the National Cancer Data Base. The results indicated that there is a trend toward no treatment at the time of diagnosis, the risk of CLL increases with age, and long term survival is poor.

    4. You have free access to this content
      Adenocarcinoma of the small bowel : Review of the National Cancer Data Base, 1985–1995 (pages 2693–2706)

      James R. Howe, Lucy H. Karnell, Herman R. Menck and Carol Scott-Conner

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991215)86:12<2693::AID-CNCR14>3.0.CO;2-U

      • original image
      • original image
      • original image
      • original image
      • original image

      Data from patients diagnosed with adenocarcinoma of the small bowel between 1985–1995 were reviewed from the National Cancer Data Base. Independent risk factors for decreased disease specific survival included patient age > 75 years, duodenal site of disease, regional or distant disease, and no cancer-directed surgery.

  4. Erratum

    1. Top of page
    2. Editorial
    3. Original Articles
    4. Communications
    5. Erratum
    1. Anatomic Site

      You have free access to this content
      Errata (pages 2707–2708)

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991215)86:12<2707::AID-CNCR15>3.0.CO;2-L

SEARCH

SEARCH BY CITATION