Chemoradiation with or without intraoperative radiation therapy in patients with locally recurrent rectal carcinoma : Prognostic factors and long term outcome (pages 2612–2624)
Vincenzo Valentini, Alessio G. Morganti, Antonio De Franco, Claudio Coco, Carlo Ratto, GianBattista Doglietto, Lucio Trodella, Luigi Ziccarelli, Aurelio Picciocchi and Numa Cellini
Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19991215)86:12<2612::AID-CNCR5>3.0.CO;2-M
Forty-seven patients with locally recurrent rectal carcinoma were enrolled in a prospective trial of preoperative chemoradiation plus surgery with or without intraoperative radiation therapy (IORT) plus postoperative adjuvant chemotherapy. Radical resection and the extent of pelvic walls involvement (using a computed tomography-based classification system) significantly predicted clinical outcome. Patients treated with IORT boost showed high 5-year local control and survival rates (79% and 41%, respectively).