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Cancer

Cover image for Cancer

1 February 2000

Volume 88, Issue 3

Pages 491–709

  1. Editorial

    1. Top of page
    2. Editorial
    3. Original Article
    4. Correspondence
    1. You have free access to this content
      Mythology and numerology in the sphere of melanoma (pages 491–496)

      A. Bernard Ackerman

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000201)88:3<491::AID-CNCR1>3.0.CO;2-P

      Many concepts about melanoma and melanocytic nevi spawned during the last third of the 20th century are subjected to scrutiny. The critique is intended not only to illuminate the subject of melanocytic neoplasia, but also to encourage colleagues to give incisive and insightful thought to new ideas and to resist woolly ones, no matter how fashionable they may be.

      See also pages 589–95.

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      Secondary leukemia : Twice is a coincidence? (pages 497–499)

      Wallace Akerley

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000201)88:3<497::AID-CNCR2>3.0.CO;2-G

      The incidence rate of secondary leukemia after cancer therapy may evolve with treatment strategy.

      See also pages 620–4.

  2. Original Article

    1. Top of page
    2. Editorial
    3. Original Article
    4. Correspondence
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      Classic Kaposi sarcoma : Epidemiology and risk factors (pages 500–517)

      Jose Iscovich, Paolo Boffetta, Silvia Franceschi, Esther Azizi and Ronit Sarid

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000201)88:3<500::AID-CNCR3>3.0.CO;2-9

      The rate of incidence of classic Kaposi sarcoma (KS) varies considerably according to country, population, gender, and age. The incidence rate of KS-associated herpesvirus (also known as human herpesvirus 8) seroprevalence in various populations correlates with the occurrence of KS.

    2. Anatomic Site

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      H-ras gene mutations in salivary gland mucoepidermoid carcinomas (pages 518–523)

      Jinyoung Yoo and Robert A. Robinson

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000201)88:3<518::AID-CNCR4>3.0.CO;2-W

      Mutational activation of the H-ras gene may contribute to the development of salivary gland mucoepidermoid carcinomas, showing a strong correlation with tumor grade.

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      Fas ligand expression in esophageal carcinomas and their lymph node metastases (pages 524–528)

      Mamoun Younes, Mary R. Schwartz, Atilla Ertan, Delia Finnie and Anas Younes

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000201)88:3<524::AID-CNCR5>3.0.CO;2-U

      Expression of Fas ligand (FasL) in greater than 25% of esophageal carcinoma cells is associated with a significantly higher incidence of lymph node metastasis, and all metastatic tumors in lymph nodes express FasL in greater than 50% of the cells.

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      Predictive factors for intrahepatic recurrence after percutaneous ethanol injection therapy for small hepatocellular carcinoma (pages 529–537)

      Masahiko Koda, Yoshikazu Murawaki, Akeri Mitsuda, Kenji Ohyama, Yutaka Horie, Takeaki Suou, Hironaka Kawasaki and Shiro Ikawa

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000201)88:3<529::AID-CNCR6>3.0.CO;2-M

      The presence of a halo and an intratumoral echo pattern on ultrasonography are useful predictors for local recurrence after percutaneous ethanol injection therapy for small hepatocellular carcinoma.

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      Is the pathologic TNM staging system for patients with hepatoma predictive of outcome? (pages 538–543)

      J. Wallis Marsh, Igor Dvorchik, C. Andrew Bonham and Shunzaburo Iwatsuki

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000201)88:3<538::AID-CNCR7>3.0.CO;2-H

      The current pathologic TNM staging system for hepatocellular carcinoma is not predictive of outcomes and should not, therefore, be used to predict outcomes or to determine the need for adjuvant therapy. A revised staging system for this disease is proposed.

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      Serum levels of des-γ-carboxy prothrombin measured using the revised enzyme immunoassay kit with increased sensitivity in relation to clinicopathologic features of solitary hepatocellular carcinoma (pages 544–549)

      Hiroaki Okuda, Toshimi Nakanishi, Kazuko Takatsu, Akiko Saito, Naoaki Hayashi, Ken Takasaki, Kazuyuki Takenami, Masakazu Yamamoto and Masayuki Nakano

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000201)88:3<544::AID-CNCR8>3.0.CO;2-F

      Des-γ-carboxy prothrombin (DCP) measured using the revised enzyme immunoassay kit with increased sensitivity (Sensitive DCP) has a stronger correlation than α-fetoprotein with the size and histologic differentiation of hepatocellular carcinoma. Sensitive DCP is a very useful marker for hepatocellular carcinoma and should be used in combination with α-fetoprotein.

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      Differential retinoblastoma and p16INK4A protein expression in neuroendocrine tumors of the lung (pages 550–556)

      Hirotoshi Dosaka-Akita, Philip T. Cagle, Hiromitsu Hiroumi, Masahiro Fujita, Motoyuki Yamashita, Anupama Sharma, Yoshikazu Kawakami and William F. Benedict

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000201)88:3<550::AID-CNCR9>3.0.CO;2-D

      All small cell lung carcinomas and large cell neuroendocrine carcinomas have abnormalities in the p16:retinoblastoma (RB) pathway, as do at least certain atypical carcinoids, whereas the p16:RB pathway is normal in typical carcinoids.

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      Gemcitabine and vinorelbine in advanced nonsmall cell lung carcinoma : A Phase II study (pages 557–562)

      Rogerio Lilenbaum, Roberto Cano, Michael Schwartz, Leonard Siegel, Jose Lutzky, Mark Lewis, Elisa Krill, Luis Barreras and Enrique Davila

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000201)88:3<557::AID-CNCR10>3.0.CO;2-5

      Gemcitabine and vinorelbine is an active and well-tolerated regimen for patients with advanced nonsmall cell lung carcinoma. This combination may be particularly suitable for the elderly or for patients who cannot tolerate more toxic platinum-based regimens.

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      Lung carcinoma in 36 patients with human immunodeficiency virus infection (pages 563–569)

      Umberto Tirelli, Michele Spina, Simonetta Sandri, Diego Serraino, Carlo Gobitti, Marco Fasan, Alessandro Sinicco, Pierluigi Garavelli, Anna Lisa Ridolfo, Emanuela Vaccher and Italian Cooperative Group on AIDS and Tumors

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000201)88:3<563::AID-CNCR11>3.0.CO;2-D

      Lung carcinoma in patients with human immunodeficiency virus infection is associated with a more adverse outcome and represents the cause of death in the majority of these patients.

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      Expression of thrombopoietin and its receptor (c-mpl) in chronic myelogenous leukemia : Correlation with disease progression and response to therapy (pages 570–576)

      Kerim Kaban, Hagop Kantarjian, Moshe Talpaz, Susan O'Brien, Jorge Cortes, Francis J. Giles, Sherry Pierce and Maher Albitar

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000201)88:3<570::AID-CNCR12>3.0.CO;2-I

      Expression of thrombopoietin and its receptor (c-mpl) did not correlate with progression of chronic myelogenous leukemia or with response to treatment or prognosis.

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      Prognostic value of intratumoral natural killer cells in gastric carcinoma (pages 577–583)

      Sumiya Ishigami, Shoji Natsugoe, Koki Tokuda, Akihiro Nakajo, Xiangming Che, Hirohumi Iwashige, Kuniaki Aridome, Shuichi Hokita and Takashi Aikou

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000201)88:3<577::AID-CNCR13>3.0.CO;2-V

      In the current study, the infiltration of natural killer cells in patients with gastric carcinoma was investigated. The number of NK cells in the tumor was found to correlate with clinicopathologic features including survival.

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      A clinical trial of intravenous vinorelbine tartrate plus tamoxifen in the treatment of patients with advanced malignant melanoma (pages 584–588)

      Lynn G. Feun, Niramol Savaraj, Judith Hurley, Angela Marini and Shenghan Lai

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000201)88:3<584::AID-CNCR14>3.0.CO;2-#

      The results of the current study indicated that intravenous vinorelbine tartrate with oral tamoxifen has activity in advanced malignant melanoma.

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      Breslow thickness and Clark level in melanoma : Support for including level in pathology reports and in American Joint Committee on Cancer Staging (pages 589–595)

      Ashfaq A. Marghoob, Karen Koenig, Flavia V. Bittencourt, Alfred W. Kopf and Robert S. Bart

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000201)88:3<589::AID-CNCR15>3.0.CO;2-I

      Multivariate analysis of the data in the New York University Melanoma Cooperative Group Registry has revealed that Clark levels of invasion add statistically significant prognostic information to the Breslow thickness ranges used in the staging system of the American Joint Committee on Cancer (AJCC). The authors believe that levels should be kept in pathology reports and as criteria in the AJCC staging system.

      See also pages 491–6.

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      Factors associated with local recurrence of mammographically detected ductal carcinoma in situ in patients given breast-conserving therapy (pages 596–607)

      Larry L. Kestin, Neal S. Goldstein, Mario D. Lacerna, Mamtha Balasubramaniam, Alvaro A. Martinez, Murray Rebner, Jane Pettinga, Robert C. Frazier and Frank A. Vicini

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000201)88:3<596::AID-CNCR16>3.0.CO;2-N

      For patients with mammographically detected ductal carcinoma in situ (DCIS) given breast-conserving therapy, adequate excision of all DCIS prior to radiation therapy can result in improved rates of local control. The volume of DCIS within 5 mm of the margin appears to be a more reliable surrogate for the adequacy of excision than the final margin status. In addition, young patient age and the absence of pathologic calcifications are independent risk factors for the development of local recurrence.

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      Morbidity following sentinel lymph node biopsy versus axillary lymph node dissection for patients with breast carcinoma (pages 608–614)

      Peter Schrenk, Roman Rieger, Andreas Shamiyeh and Wolfgang Wayand

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000201)88:3<608::AID-CNCR17>3.0.CO;2-K

      Sentinel lymph node biopsy in patients with invasive breast carcinoma largely reduces postoperative arm morbidity compared with Level I and II axillary dissection. Therefore, sentinel lymph node biopsy may be an alternative to complete axillary lymph node dissection in lymph node negative breast carcinoma patients, because it combines accurate lymph node staging with low postoperative morbidity.

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      Use of complementary health practices by prostate carcinoma patients undergoing radiation therapy (pages 615–619)

      Gary D. Kao and Pamela Devine

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000201)88:3<615::AID-CNCR18>3.0.CO;2-P

      Personal interviews of 50 consecutive men who were undergoing radiation therapy for prostate carcinoma revealed that over one-third utilized complementary health practices not recommended by or communicated to their physicians. Patients who used complementary health practices tended to have higher levels of education and income levels, whereas there were no differences in age, religion, or perception of health status.

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      Acute myelogenous leukemia after exposure to strontium-89 for the treatment of adenocarcinoma of the prostate (pages 620–624)

      Steven E. Kossman and Mark A. Weiss

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000201)88:3<620::AID-CNCR19>3.0.CO;2-#

      The authors report the development of secondary acute myelogenous leukemia after strontium-89 therapy for prostate carcinoma in two patients. This represents an important event that may be observed with increasing frequency as radiopharmaceutical therapy is used more often in patients with prostate carcinoma.

      See also pages 497–9.

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      Flat intraepithelial lesions of the urinary bladder (pages 625–631)

      Liang Cheng, John C. Cheville, Roxann M. Neumann and David G. Bostwick

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000201)88:3<625::AID-CNCR20>3.0.CO;2-A

      Patients with a diagnosis of urothelial atypia of unknown significance or reactive atypia do not have adverse clinical outcomes, whereas patients with urothelial dysplasia of the bladder have an increased risk for the development of carcinoma in situ and urothelial carcinoma.

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      Inverted urothelial papilloma : Is ploidy, MIB-1 proliferative activity, or p53 protein accumulation predictive of urothelial carcinoma? (pages 632–636)

      John C. Cheville, Kevin Wu, Thomas J. Sebo, Liang Cheng, Darren Riehle, Christine M. Lohse and V. Shane Pankratz

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000201)88:3<632::AID-CNCR21>3.0.CO;2-F

      Approximately 16% of patients with inverted urothelial papilloma developed urothelial carcinoma. There were no significant differences in MIB-1 activity, p53 protein staining, or morphologic features between inverted papillomas in patients with and without a history of urothelial carcinoma. In addition, aneuploidy in inverted papilloma was not associated with prior, concurrent, or subsequent urothelial carcinoma.

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      Safety and efficacy of a multicenter study using intraarterial chemotherapy in conjunction with osmotic opening of the blood-brain barrier for the treatment of patients with malignant brain tumors (pages 637–647)

      Nancy D. Doolittle, Michael E. Miner, Walter A. Hall, Tali Siegal, E. Jerome Hanson, Eva Osztie, Leslie D. McAllister, Joseph S. Bubalo, Dale F. Kraemer, David Fortin, Randal Nixon, Leslie L. Muldoon and Edward A. Neuwelt

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000201)88:3<637::AID-CNCR22>3.0.CO;2-Y

      In the hands of consistent investigators using standard clinical guidelines and protocols, intraarterial chemotherapy with or without osmotic opening of the blood-brain barrier is feasible across multiple centers, with a low incidence of catheter-related complications and an efficacy profile that is reproducible across centers.

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      Feasibility and early results of accelerated radiotherapy for head and neck carcinoma in the elderly (pages 648–652)

      Abdelkarim S. Allal, Daphné Maire, Minerva Becker and Pavel Dulguerov

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000201)88:3<648::AID-CNCR23>3.0.CO;2-R

      The results of the current study found that accelerated concomitant boost radiotherapy is feasible in elderly patients with head and neck carcinoma. The acute and late toxicities appear to be similar to those observed in younger patients, and treatment outcomes appear comparable.

    22. General Topic

      Cancer Comorbidity
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      Cancer and comorbidity : Redefining chronic diseases (pages 653–663)

      Karen S. Ogle, G. Marie Swanson, Nancy Woods and Faouzi Azzouz

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000201)88:3<653::AID-CNCR24>3.0.CO;2-1

      Comorbid chronic diseases were surprisingly common in this population-based sample of 15,626 cancer patients, and appear to have important clinical, health service, and research implications for care models.

    23. Cancer Screening
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      Early findings from a community-based, cluster-randomized, controlled oral cancer screening trial in Kerala, India (pages 664–673)

      Rengaswamy Sankaranarayanan, Babu Mathew, Binu Jose Jacob, Gigi Thomas, Thara Somanathan, Paola Pisani, Manoj Pandey, Kunnambath Ramadas, K. Najeeb, Elizabeth Abraham and Trivandrum Oral Cancer Screening Study Group

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000201)88:3<664::AID-CNCR25>3.0.CO;2-V

      Results from a cluster-randomized, controlled oral cancer screening trial in Kerala, India, demonstrated significantly earlier stage at diagnosis and a lower rate of case fatality in the intervention group compared with the control group at the end of the first round of screening, though only 52.4% of the subjects with positive screenings reported for confirmatory examination.

    24. Life Style of Patients after Treatment for Cancer
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      Current health behaviors and readiness to pursue life-style changes among men and women diagnosed with early stage prostate and breast carcinomas (pages 674–684)

      Wendy Demark-Wahnefried, Bercedis Peterson, Colleen McBride, Isaac Lipkus and Elizabeth Clipp

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000201)88:3<674::AID-CNCR26>3.0.CO;2-R

      A mailed survey completed by 978 men and women diagnosed with early stage breast or prostate carcinoma suggested that a large proportion of these individuals are receptive to and could benefit from health promotion programs focused on improving diet and promoting physical activity. There appeared to be a strong preference for programs delivered via mail and within 6 months of diagnosis.

    25. Pediatric Oncology
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      Radiotherapy followed by high dose busulfan and thiotepa : A prospective assessment of high dose chemotherapy in children with diffuse pontine gliomas (pages 685–692)

      Eric Bouffet, Marianne Raquin, Francois Doz, Jean-Claude Gentet, Chantal Rodary, Francois Demeocq, Pascal Chastagner, Patrick Lutz, Olivier Hartmann and Chantal Kalifa

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000201)88:3<685::AID-CNCR27>3.0.CO;2-K

      In this pilot study, children with diffuse brainstem glioma were treated with conventional radiotherapy followed by high dose chemotherapy and progenitor cell transplantation. No survival advantage was observed with this intensive regimen.

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      Cerebral glucose metabolism in survivors of childhood acute lymphoblastic leukemia (pages 693–700)

      Meri Kähkönen, Liisa Metsähonkala, Heikki Minn, Tapio Utriainen, Tapio Korhonen, Marja-Kaisu Norvasuo-Heilä, Arja Harila-Saari, Tuula Äärimaa, Hanna Suhonen-Polvi, Ulla Ruotsalainen, Olof Solin and Toivo T. Salmi

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000201)88:3<693::AID-CNCR28>3.0.CO;2-M

      Forty long term survivors of childhood acute lymphoblastic leukemia were studied using [18F]-fluorodeoxyglucose positron emission tomography. Cranial radiation therapy used as central nervous system prophylaxis did not appear to have any effect on cerebral glucose utilization.

    27. Quality of Life
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      Evaluating the quality of cancer care : Development of cancer quality indicators for a global quality assessment tool (pages 701–707)

      Jennifer L. Malin, Steven M. Asch, Eve A. Kerr and Elizabeth A. McGlynn

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000201)88:3<701::AID-CNCR29>3.0.CO;2-V

      The authors developed cancer specific quality indicators using a novel case-based approach for a quality measurement tool designed to compare different managed care organizations.

  3. Correspondence

    1. Top of page
    2. Editorial
    3. Original Article
    4. Correspondence
    1. General Topic

      You have free access to this content
      Human immunodeficiency virus negative Kaposi sarcoma and lymphoproliferative disorders (pages 708–709)

      M. Kadri Altundağ and İsmail Çelik

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000201)88:3<708::AID-CNCR30>3.0.CO;2-#

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      Author reply (page 709)

      Lucia Brambilla, Vinicio Boneschi, Silvia Ferrucci and Silvia Fossati

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000201)88:3<709::AID-CNCR31>3.0.CO;2-U

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