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Cancer

Cover image for Cancer

15 February 2000

Volume 88, Issue 4

Pages 711–967

  1. Review Article

    1. Top of page
    2. Review Article
    3. Original Article
    4. Communication
    5. Correspondence
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      Adrenocortical carcinoma : Clinical and laboratory observations (pages 711–736)

      Bernardo Leo Wajchenberg, Maria A. Albergaria Pereira, Berenice B. Medonca, Ana C. Latronico, Paulo Campos Carneiro, Venancio A. Ferreira Alves, Maria Claudia N. Zerbini, Bernardo Liberman, Gilberto Carlos Gomes and Marvin A. Kirschner

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000215)88:4<711::AID-CNCR1>3.0.CO;2-W

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      Adrenal carcinoma in children is associated with virilism and a less aggressive natural history; in adults it presents as a mixed Cushing-virilizing syndrome and has a virulent course. The Weiss histologic criteria correlate best with disease prognosis, but other histochemical, cell cycle, and genetic markers have not yet been found to aid in disease management.

  2. Original Article

    1. Top of page
    2. Review Article
    3. Original Article
    4. Communication
    5. Correspondence
    1. Anatomic Site

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      Vitamins, carotenoids, dietary fiber, and the risk of gastric carcinoma : Results from a prospective study after 6.3 years of follow-up (pages 737–748)

      Anita A. M. Botterweck, Piet A. van den Brandt and R. Alexandra Goldbohm

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000215)88:4<737::AID-CNCR2>3.0.CO;2-H

      The results of the current study found no protective effect of vitamin E, folate, α-carotene, lutein plus zeaxanthin, lycopene, β-cryptoxanthin, and dietary fiber intake for the prevention of gastric carcinoma; only vitamin C appeared to have any protective effect. Retinol and β-carotene were associated positively with gastric carcinoma risk.

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      Molecular identification of metastatic cancer to the skin using laser capture microdissection : A case report (pages 749–754)

      Sara Milchgrub, Ignacio I. Wistuba, Bong K. Kim, Cynthia Rutherford, Jill Urban, Ponciano D. Cruz Jr. and Adi F. Gazdar

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000215)88:4<749::AID-CNCR3>3.0.CO;2-9

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      A 57-year-old woman with a previously resected duodenal carcinoid presented with a rapidly expanding scalp tumor of uncertain histopathologic diagnosis. Molecular analyses showed an identical pattern of genetic abnormalities in both the scalp and duodenal tumors, strongly supporting a diagnosis of cutaneous metastasis from the carcinoid tumor.

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      Adenomatous polyposis coli I1307K mutation in Jewish patients with different ethnicity : Prevalence and phenotype (pages 755–760)

      Liat Drucker, Ofer Shpilberg, Avivit Neumann, Jermey Shapira, Rodica Stackievicz, Yoram Beyth and Shai Yarkoni

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000215)88:4<755::AID-CNCR4>3.0.CO;2-7

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      The adenomatous polyposis coli I1307K mutation, predisposing to colorectal carcinoma, appears to be segregated in populations of different origins at significant levels. The phenotype of the mutation is uncharacteristic for a germline mutation in a tumor suppressor gene and low penetrance is suggested.

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      Abnormal expression of hepatoma specific γ-glutamyl transferase and alteration of γ-glutamyl transferase gene methylation status in patients with hepatocellular carcinoma (pages 761–769)

      Dengfu Yao, Daorong Jiang, Zhongwei Huang, Jianxin Lu, Qiyuan Tao, Zhijian Yu and Xianyong Meng

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000215)88:4<761::AID-CNCR5>3.0.CO;2-5

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      The abnormal alteration of serum hepatoma specific γ-glutamyl transferase (GGT) concentration is a sensitive tumor marker for hepato cellular carcinoma (HCC) diagnosis or differentiation, and the overexpression of GGT in the development of HCC may be related to hypomethylational status of GGT gene CCGG sites.

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      Treatment of carcinoid syndrome : A prospective crossover evaluation of lanreotide versus octreotide in terms of efficacy, patient acceptability, and tolerance (pages 770–776)

      Dermot O'Toole, Michel Ducreux, Gilles Bommelaer, Jean-Louis Wemeau, Olivier Bouché, France Catus, Joëlle Blumberg and Philippe Ruszniewski

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000215)88:4<770::AID-CNCR6>3.0.CO;2-0

      Lanreotide and octreotide are equally effective in controlling carcinoid syndrome; however, patients prefer lanreotide due to its simplified mode of administration.

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      Current follow-up strategies after potentially curative resection of extremity sarcomas : Results of a survey of the members of the society of surgical oncology (pages 777–785)

      Alan L. Beitler, Katherine S. Virgo, Frank E. Johnson, John F. Gibbs and William G. Kraybill

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000215)88:4<777::AID-CNCR7>3.0.CO;2-R

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      Postoperative sarcoma surveillance strategies utilized by members of the Society of Surgical Oncology rely most heavily on office visits and chest X-ray. Tumor grade, tumor size, and postoperative year affect surveillance intensity.

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      Menstrual and reproductive factors and risk of soft tissue sarcomas (pages 786–789)

      Francesca Fioretti, Alessandra Tavani, Silvano Gallus, Eva Negri, Silvia Franceschi and Carlo La Vecchia

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000215)88:4<786::AID-CNCR8>3.0.CO;2-M

      The risk of soft tissue sarcoma was found to be related directly to late age at first pregnancy and birth, but not to other menstrual and reproductive factors.

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      High dose chemotherapy and autologous blood stem cell support in women with breast carcinoma and isolated supraclavicular lymph node metastases (pages 790–795)

      Rick Abraham, Tracy Nagy, Paul E. Goss and Michael Crump

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000215)88:4<790::AID-CNCR9>3.0.CO;2-M

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      Women with supraclavicular lymph node metastases who have low volume metastatic breast carcinoma may benefit the most from high dose chemotherapy and stem cell transplantation. The current study reports the long term outcome of a series of 20 such patients.

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      The predictive value of body protein for chemotherapy-induced toxicity (pages 796–803)

      Alireza Aslani, Ross C. Smith, Barry J. Allen, Nicholas Pavlakis and John A. Levi

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000215)88:4<796::AID-CNCR10>3.0.CO;2-P

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      The nitrogen index, which is derived from total body nitrogen measurements in women receiving cyclophosphamide, methotrexate, and 5-fluorouracil based chemotherapy, was found to predict chemotherapy-induced neutropenia more accurately than body surface area.

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      The prognostic value of p53 and c-erb b-2 immunostaining is overrated for patients with lymph node negative breast carcinoma : A multivariate analysis of prognostic factors in 613 patients with a follow-up of 14–30 years (pages 804–813)

      Wenche Reed, Einar Hannisdal, Per Johannes Boehler, Stein Gundersen, Herman Host and Jahn Marthin Nesland

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000215)88:4<804::AID-CNCR11>3.0.CO;2-Y

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      p53 and c-erb B-2 have no independent prognostic value for patients with lymph node negative breast carcinoma, whereas histologic grade and tumor size are major prognostic factors and also were found to be significant after 30 years of follow-up.

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      The frequency of p53, k-ras mutations, and microsatellite instability differs in uterine endometrioid and serous carcinoma : Evidence of distinct molecular genetic pathways (pages 814–824)

      Sigurd F. Lax, Brian Kendall, Hironori Tashiro, Robbert J. C. Slebos and Lora Hedrick Ellenson

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000215)88:4<814::AID-CNCR12>3.0.CO;2-U

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      The frequency of p53 and K-ras mutations and microsatellite instability differs in uterine endometrioid and serous carcinomas, providing evidence of distinct molecular genetic pathways in the development of these two types of endometrial carcinoma.

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      A randomized study comparing standard versus moderately high dose megestrol acetate for patients with advanced prostate carcinoma : Cancer and Leukemia Group B study 9181 (pages 825–834)

      Nancy A. Dawson, Mark Conaway, Susan Halabi, Eric P. Winer, Eric J. Small, Diana Lake and Nicholas J. Vogelzang

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000215)88:4<825::AID-CNCR13>3.0.CO;2-N

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      One hundred forty-nine men with hormone-refractory prostate carcinoma were randomized to either megestrol acetate 160 mg/day or megestrol acetate 640 mg/day. Overall, megestrol acetate's limited activity and an apparent flare of bone pain in 7% of men make its routine use as a second-line hormonal therapy inadvisable.

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      Independent value of tumor size and DNA ploidy for the prediction of disease progression in patients with organ-confined renal cell carcinoma (pages 835–843)

      Franco Di Silverio, Paolo Casale, Dario Colella, Loreto Andrea, Fulvia Seccareccia and Alessandro Sciarra

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000215)88:4<835::AID-CNCR14>3.0.CO;2-J

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      Despite a significant positive association between DNA content and tumor size, in the current study, multivariate analysis found these factors to be the only two independent predictors of disease progression in patients with organ-confined renal cell carcinoma. If tumors of different size have a different biology associated with DNA content values, a combined assessment would improve the ability to predict disease progression.

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      Paraganglioma of the urinary bladder : Can biologic potential be predicted? (pages 844–852)

      Liang Cheng, Bradley C. Leibovich, John C. Cheville, Dharamdas M. Ramnani, Thomas J. Sebo, Roxann M. Neumann, Antonio G. Nascimento, Horst Zincke and David G. Bostwick

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000215)88:4<844::AID-CNCR15>3.0.CO;2-I

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      Paraganglioma of the urinary bladder usually occurs in young adult women. Patients with tumor of advanced classification (≥T3) are at risk of recurrence, metastasis, and dying of the disease, whereas patients in this study with T1 or T2 disease had favorable outcomes after complete tumor resection.

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      Atypical nephrogenic metaplasia of the urinary tract : A precursor lesion? (pages 853–861)

      Liang Cheng, John C. Cheville, Thomas J. Sebo, John N. Eble and David G. Bostwick

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000215)88:4<853::AID-CNCR16>3.0.CO;2-H

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      Atypical nephrogenic metaplasia is a benign lesion without apparent malignant potential. It should be considered in the differential diagnosis of adenocarcinoma, and awareness of this entity may avoid misinterpretation or overdiagnosis of cancer.

    16. Anatomic Site

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      Evaluation of cell proliferation, epidermal growth factor receptor, and bcl-2 immunoexpression as prognostic factors for patients with world health organization grade 2 oligodendroglioma (pages 862–869)

      Jorge S. Reis-Filho, Leonardo N. Faoro, Carla Carrilho, Luiz F. Bleggi-Torres and Fernando C. Schmitt

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000215)88:4<862::AID-CNCR17>3.0.CO;2-G

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      A proliferation index (PI) > 9%, a MIB-1 PI >5%, and the presence of mitoses correlate with a shorter disease free survival for patients with World Health Organization Grade 2 oligodendrogliomas.

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      Stereotactic radiosurgery for recurrent ependymoma (pages 870–875)

      Scott L. Stafford, Bruce E. Pollock, Robert L. Foote, Deborah A. Gorman, Diana F. Nelson and Paula J. Schomberg

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000215)88:4<870::AID-CNCR18>3.0.CO;2-I

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      Patients with recurrent intracranial ependymomas have a dismal long term prognosis. The current study evaluated the impact of stereotactic radiosurgery on patients with recurrent ependymomas to assess local control, overall survival, and complications in this high risk patient population.

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      Mature results of a Phase III randomized trial comparing concurrent chemoradiotherapy with radiation therapy alone in patients with Stage III and IV squamous cell carcinoma of the head and neck (pages 876–883)

      David J. Adelstein, Pierre Lavertu, Jerrold P. Saxton, Michelle Secic, Benjamin G. Wood, John R. Wanamaker, Isaac Eliachar, Marshall Strome and Marjorie A. Larto

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000215)88:4<876::AID-CNCR19>3.0.CO;2-Y

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      This Phase III randomized trial compared radiation therapy with radiation and concurrent chemotherapy with cisplatin and 5-fluorouracil in 100 patients with American Joint Committee on Cancer Stage III and IV squamous cell carcinoma of the head and neck. Improvements in disease clearance, recurrence free interval, and primary site preservation, but not overall survival, were found for the patients treated with chemoradiotherapy.

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      The origins of multiple squamous cell carcinomas in the aerodigestive tract (pages 884–893)

      Monique G. C. T. van Oijen, Fredriek G. J. Leppers vd Straat, Marcel G. J. Tilanus and Pieter J. Slootweg

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000215)88:4<884::AID-CNCR20>3.0.CO;2-S

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      By employing mutation analysis of the entire coding region of p53 and loss of heterozygosity pattern analysis of microsatellite markers on chromosome arms 3p, 9p, and 17p, this study found that metachronous head and neck squamous cell carcinomas from different locations are not clonally related and thus have not developed after the migration of tumor cells. In the second part of this study, these clonal markers were successively applied in 11 patients for whom there was uncertainty as to whether their second squamous cell carcinoma in the aerodigestive tract was a recurrent tumor, a second primary tumor, or a metastasis.

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      Bone marrow staging of patients with non-Hodgkin lymphoma by flow cytometry : Correlation with morphology (pages 894–899)

      Peter R. Duggan, David Easton, Joanne Luider and Iwona A. Auer

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000215)88:4<894::AID-CNCR21>3.0.CO;2-O

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      Neither morphologic examination of bone marrow biopsies nor flow cytometry alone is adequate to detect all cases of non-Hodgkin lymphoma (NHL) with bone marrow involvement. Flow cytometry is more sensitive than morphology in the detection of minimal disease, potentially affecting the stage of disease for some patients with early stage NHL.

    21. General Topic

      Palliative Care
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      Assessment of the need for palliative care as perceived by individual cancer patients and their families : A review of instruments for improving patient participation in palliative care (pages 900–911)

      Bart H. P. Osse, Myrra J. F. J. Vernooij-Dassen, Berna P. W. de Vree, Egbert Schadé and Richard P. T. M. Grol

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000215)88:4<900::AID-CNCR22>3.0.CO;2-2

      A systematic approach to the assessment of the palliative care needs of individual patients with cancer may improve the quality of care. This literature review provides an evaluation of instruments for clinical assessment of the needs for care experienced by cancer patients and their primary caregivers.

  3. Communication

    1. Top of page
    2. Review Article
    3. Original Article
    4. Communication
    5. Correspondence
    1. General Topic

      The American College of Surgeons Commission on Cancer and the American Cancer Society
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      The National Cancer Data Base report on treatment patterns for hepatocellular carcinomas : Improved survival of surgically resected patients, 1985–1996 (pages 912–920)

      William G. Cance, Andrew K. Stewart and Herman R. Menck

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000215)88:4<912::AID-CNCR23>3.0.CO;2-T

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      The patterns of care and survival experience of 11,156 patients diagnosed with hepatocellular carcinoma in 1985–1986, 1990–1991, and 1995–1996 were examined.

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      The National Cancer Data Base report on poor survival of U.S. gastric carcinoma patients treated with gastrectomy : Fifth edition American Joint Committee on Cancer staging, proximal disease, and the “different disease” hypothesis (pages 921–932)

      Scott A. Hundahl, Jerri Linn Phillips and Herman R. Menck

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000215)88:4<921::AID-CNCR24>3.0.CO;2-S

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      This report describes an analysis of National Cancer Data Base gastric carcinoma patients treated with gastrectomy between 1985 and 1996. Survival stratified according to fifth edition American Joint Committee on Cancer staging, when compared with survival in other surgical series from Japan and Germany, appears problematic. The problem is illuminated by findings for Japanese Americans, with subsite analysis and reflections on staging.

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      National Cancer Data Base survey of breast cancer management for patients from low income zip codes (pages 933–945)

      LaMar S. McGinnis, Herman R. Menck, Harmon J. Eyre, Kirby I. Bland, Carol E. H. Scott-Conner, Monica Morrow and David P. Winchester

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000215)88:4<933::AID-CNCR25>3.0.CO;2-I

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      Further improvements in the early diagnosis and surgical treatment of low income patients can probably be achieved. Programmatic activities that further explain or reduce the apparent nonpreferred treatment of some low income patients should be encouraged.

    4. Consensus Conference on the Ductal Carcinoma of the Breast, April 22–25, 1999
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      Consensus Conference on the Classification of Ductal Carcinoma of the Breast, April 22–25, 1999 (pages 946–954)

      Gordon F. Schwartz, Lawrence J. Solin, Ivo A. Olivotto, Virginia L. Ernster, Peter I. Pressman and The Consensus Conference Committee

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000215)88:4<946::AID-CNCR26>3.0.CO;2-5

      This conference, a sequel to the Consensus Conference on the Classification of Ductal Carcinoma In Situ (DCIS) held in Philadelphia in 1997, focused on the epidemiology, diagnosis, treatment, adjuvant therapy, follow-up, prognostic markers, and reporting end points of DCIS. The end points of treatment discussed at the conference included breast conservation with appropriate cosmesis; risks of recurrence, metastasis, contralateral DCIS, and invasive cancer; and mortality specific to breast carcinoma.

    5. International Union Against Cancer (UICC)
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      Report on Prostate Cancer Tumor Marker Workshop 1999 (pages 955–963)

      Alan W. Partin, Gerald P. Murphy and Michael K. Brawer

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000215)88:4<955::AID-CNCR27>3.0.CO;2-4

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      This is a report on the current new markers in the serum for prostate cancer diagnosis and follow-up, which were discussed at this International Union Against Cancer (UICC) Tumor Biology Committee Program Meeting held in Whistler, British Columbia, Canada, on July 17–18, 1999.

  4. Correspondence

    1. Top of page
    2. Review Article
    3. Original Article
    4. Communication
    5. Correspondence
    1. General Topic

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      Multiple chondromatous hamartomas of the lung : A case report and review of the literature with special reference to Carney syndrome (page 964)

      Şuayib Yalçin and Ayşe Kars

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000215)88:4<964::AID-CNCR28>3.0.CO;2-3

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      Author reply (page 965)

      Takuji Kiryu, Shimpei Kawaguchi, Eisuke Matsui, Hiroaki Hoshi, Mitsuharu Kokubo and Kuniyasu Shimokawa

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000215)88:4<965::AID-CNCR29>3.0.CO;2-Y

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      Trilateral retinoblastoma : Is the location of the intracranial tumor important? (pages 965–966)

      Annette C. Moll, Saskia M. Imhof, Antoinette Y. N. Schouten-van Meeteren and Maarten Boers

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000215)88:4<965::AID-CNCR30>3.0.CO;2-N

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      Author reply (pages 966–967)

      Arnold C. Paulino

      Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000215)88:4<966::AID-CNCR31>3.0.CO;2-H

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