• Please log in or register to access this feature.

Original Article

You have full text access to this OnlineOpen article

Microinvasive breast carcinoma

Clinicopathologic analysis of a single institution experience

  1. Ruth F. Padmore M.D., Ph.D.1,†,
  2. Barbara Fowble M.D.2,
  3. John Hoffman M.D.3,
  4. Cindy Rosser2,
  5. Alexandra Hanlon Ph.D.2,
  6. Arthur S. Patchefsky M.D.1,*

Article first published online: 20 NOV 2000

DOI: 10.1002/(SICI)1097-0142(20000315)88:6<1403::AID-CNCR18>3.0.CO;2-S

Issue

Cancer

Cancer

Volume 88, Issue 6, pages 1403–1409, 15 March 2000

Additional Information

How to Cite

Padmore, R. F., Fowble, B., Hoffman, J., Rosser, C., Hanlon, A. and Patchefsky, A. S. (2000), Microinvasive breast carcinoma. Cancer, 88: 1403–1409. doi: 10.1002/(SICI)1097-0142(20000315)88:6<1403::AID-CNCR18>3.0.CO;2-S

Author Information

  1. 1

    Department of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania

  2. 2

    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania

  3. 3

    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania

  1. †

    Department of Laboratory Medicine, The Ottawa Hospital, Ottawa, Ontario, Canada

*Department of Pathology, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111

Publication History

  1. Issue published online: 20 NOV 2000
  2. Article first published online: 20 NOV 2000
  3. Manuscript Revised: 10 DEC 1999
  4. Manuscript Accepted: 10 DEC 1999
  5. Manuscript Received: 30 APR 1999

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (175K)

REFERENCES

  • 1
    Schnitt SJ. Microinvasive carcinoma of the breast. Int J Surg Pathol 1998; 6: 183–8.
  • 2
    Silverstein MJ, Waisman JR, Gamagami P, Gierson ED, Colburn WJ, Rosser RJ, et al. Intraductal carcinoma of the breast (208 cases). Clinical factors influencing treatment choice. Cancer 1990;66: 102–8.
    Direct Link:
  • 3
    Silver SA, Tavassoli FA. Mammary ductal carcinoma in situ with microinvasion. Cancer 1998; 82: 2382–90.
    Direct Link:
  • 4
    Schwartz GF, Patchefsky AS, Feig SA, Shaber GS, Schwartz AB. Multicentricity of non-palpable breast cancer. Cancer 1980; 45: 2913–6.
    Direct Link:
  • 5
    Schwartz GF, Patchefsky AS, Finkelstein SD, Sohn SH, Prestipino A, Feig SA, et al. Non-palpable in situ ductal carcinoma of the breast: predictors of multicentricity and microinvasion and implications for treatment. Arch Surg 1989; 124: 29–32.
  • 6
    Lagios MD. Microinvasion in ductal carcinoma in situ. In: SilversteinMJ, editor. Ductal carcinoma in situ of the breast. Baltimore: Williams & Wilkins, 1997: 241–6.
  • 7
    Rosen PP. In situ (intra-epithelial) carcinoma: an overview. In: Rosen's breast pathology. Philadelphia: Lippincott-Raven, 1997: 260–5.
  • 8
    Fechner RE, Mills SE. Ductal carcinoma in situ. In: Breast pathology. Benign proliferations, atypias & in situ carcinomas. Chicago: ASCP Press, 1990: 114–5.
  • 9
    Solin LJ, Fowble BL, Yeh I-T, Kowalyshyn MJ, Schultz DJ, Weiss MC, et al. Microinvasive ductal carcinoma of the breast treated with breast-conserving surgery and definitive irradiation. Int J Radiat Oncol Biol Phys 1992; 23: 961–8.
  • 10
    Wong JH, Kopald KH, Morton DL. The impact of microinvasion on axillary node metastases and survival in patients with intraductal breast cancer. Arch Surg 1990; 125: 1298–302.
  • 11
    Lagios MD. Ductal carcinoma in situ: biological and therapeutic implications of classification. Breast J 1996; 2: 32-4.
    Direct Link:
  • 12
    The Consensus Conference Committee. Consensus conference on the classification of ductal carcinoma in situ. Cancer 1997; 80: 1798–802.
    Direct Link:
  • 13
    Elston CW. Grading of invasive carcinoma of the breast. In: PageDL, AndersonTJ, editors. Diagnostic histopathology of the breast. Edinburgh: Churchill Livingstone, 1987: 300–11.
  • 14
    FlemingID, CooperJS, HensonDE, HutterRVP, KennedyBJ, MurphyGP, et al. editors. American Joint Committee on Cancer cancer staging manual. 5th edition. Philadelphia: Lippincott-Raven, 1997: 171–80.
  • 15
    Silverstein MJ. Ductal carcinoma in situ with microinvasion. In: SilversteinMJ, editor. Ductal carcinoma in situ of the breast. Baltimore: Williams & Wilkins, 1997: 557–62.
  • 16
    Prasad ML, Giri D, Hoda S. Clinicopathological features of microinvasive (<1 mm) carcinoma of breast. Lab Invest 1998; 78: 25A.
  • 17
    Karp SE, Tonin PN, Bégin LR, Martinez JJ, Zhang JC, Pollak MN, et al. Influence of BRCA1 mutations on nuclear grade and estrogen receptor status of breast carcinoma in Ashkenazi Jewish women. Cancer 1997; 80: 435–41.
    Direct Link:
  • 18
    Breast Cancer Linkage Consortium. Pathology of familial breast cancer: differences between breast cancers in carriers of BRCA1 and BRCA2 mutations and sporadic cases. Lancet 1997; 349: 1505–10.
  • 19
    Anscher MS, Jones P, Prosnitz LR, Blackstock W, Hebert M, Reddick R, et al. Local failure and margin status in early-stage breast carcinoma treated with conservation surgery and radiation therapy. Ann Surg 1993; 218: 22–8.
  • 20
    Jimenez RE, Visscher DW. Clinicopathologic analysis of microscopically invasive breast carcinoma. Hum Pathol 1998; 29: 1412–9.
  • 21
    Zavotsky J, Hansen N, Brennan MB, Turner RR, Giuliano AE. Lymph node metastasis from ductal carcinoma in situ with microinvasion. Cancer 1999; 85: 2439–43.
    Direct Link:
  • 22
    Kinne DW, Petrek JA, Osborne MP, Fracchia AA, DePalo AA, Rosen PP. Breast carcinoma in situ. Arch Surg 1989; 124: 33–6.
  • 23
    Patchefsky AS, Schwartz GF, Finkelstein SD, Prestipino A, Sohn SE, Singer JS, et al. Heterogeneity of intraductal carcinoma of the breast. Cancer 1989; 63: 731–41.
    Direct Link:
  • 24
    Rosner D, Lane WW, Penetrante R. Ductal carcinoma in situ with microinvasion. Cancer 1991; 67: 1498–503.
    Direct Link:
  • 25
    Maibenco DC, Weiss LK, Pawlish KS, Severson RK. Axillary lymph node metastases associated with small invasive breast carcinomas. Cancer 1999; 85: 1530–6.
    Direct Link:
  • 26
    Gage I, Schnitt SJ, Nixon AJ, Silver B, Recht A, Troyan SL, et al. Pathologic margin involvement and the risk of recurrence in patients treated with breast-conserving therapy. Cancer 1996; 78: 1921–8.
    Direct Link:
  • 27
    Sinn HP, Oelmann A, Anton HW, Diel IJ. Metastatic potential of small and minimally invasive breast carcinomas. Virchows Arch 1994; 425: 237–41.
  • 28
    Russo SA, Fowble B, Fox K, Solin LJ, Schultz DJ. The identification of a subset of patients with axillary node-negative minimally invasive breast cancer who may benefit from adjuvant systemic therapy. Breast J 1995; 1: 163–72.
    Direct Link:
View Full Article (HTML) Get PDF (175K)