Anatomic Site
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Telomerase activity as an indicator of malignant potential in iodine-nonreactive lesions of the esophagus (pages 1524–1529)Kazuo Koyanagi, Soji Ozawa, Nobutoshi Ando, Makio Mukai, Yuko Kitagawa, Masakazu Ueda and Masaki Kitajima
Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000401)88:7<1524::AID-CNCR4>3.0.CO;2-6
In esophageal mucosa, carcinoma in situ and dysplasia typically are iodine-nonreactive. In these cases, positive telomerase activity indicates the presence of immortalized tumor cells and thus influences the choice of treatment.
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Assessment of gastric carcinoma risk associated with Helicobacter pylori may vary depending on the antigen used : Caga specific enzyme-linked immunoadsorbent assay (ELISA) versus commercially available H. pylori ELISAs (pages 1530–1535)Shin Maeda, Haruhiko Yoshida, Keiji Ogura, Yutaka Yamaji, Tsuneo Ikenoue, Toru Mitsushima, Hitoshi Tagawa, Ryuji Kawaguchi, Kiyoshi Mori, Ken-ichi Mafune, Takao Kawabe, Yasushi Shiratori and Masao Omata
Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000401)88:7<1530::AID-CNCR5>3.0.CO;2-4
This study determined the odds ratios for gastric carcinoma associated with seropositivity for different antibodies against Helicobacter pylori. These odds ratios varied depending on the antibody measured, from a nonsignificant odds ratio of 1.3 with HM-CAP to a highly significant odds ratio of 10.4 with the anti-CagA antibody assay.
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Thomsen-Friedenreich antigen presents as a prognostic factor in colorectal carcinoma : A clinicopathologic study of 264 patients (pages 1536–1543)Stephan E. Baldus, Thomas K. Zirbes, Franz-Georg Hanisch, Doreen Kunze, Sven T. Shafizadeh, Silke Nolden, Stefan P. Mönig, Paul M. Schneider, Uwe Karsten, Juergen Thiele, Arnulf H. Hölscher and Hans P. Dienes
Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000401)88:7<1536::AID-CNCR6>3.0.CO;2-W
The Thomsen-Friedenreich disaccharide antigen is expressed in the majority of colorectal carcinomas and is a marker of low survival probability. Furthermore, it represents a carrier specific glycotope of MUC1 mucin antigen in a great number of cases.
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Prognostic influence of tumor-associated eosinophilic infiltrate in colorectal carcinoma (pages 1544–1548)M. J. Fernández-Aceñero, M. Galindo-Gallego, J. Sanz and A. Aljama
Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000401)88:7<1544::AID-CNCR7>3.0.CO;2-S
Eosinophil count in histologic sections stained with hematoxylin and eosin served as a significant independent favorable prognosticator for patients with colorectal carcinoma.
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Limited but definite efficacy of prophylactic hepatic arterial infusion chemotherapy after curative resection of colorectal liver metastases : A randomized study (pages 1549–1556)Takeshi Tono, Yasunori Hasuike, Hiroki Ohzato, Yuichi Takatsuka and Nobuteru Kikkawa
Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000401)88:7<1549::AID-CNCR8>3.0.CO;2-K
Short term hepatic arterial administration of 5-fluorouracil after curative resection of colorectal liver metastases was found to improve significantly disease free survival of nine patients in the current study compared with ten randomized control patients, with no serious complications noted.
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Unique clinical characteristics of patients with hepatocellular carcinoma who present with high plasma des-γ-carboxy prothrombin and low serum α-fetoprotein (pages 1557–1564)Keisuke Hamamura, Yasushi Shiratori, Shuichiro Shiina, Masatoshi Imamura, Shuntaro Obi, Shinpei Sato, Haruhiko Yoshida and Masao Omata
Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000401)88:7<1557::AID-CNCR9>3.0.CO;2-G
Patients who have hepatocellular carcinoma with elevated plasma des-γ-carboxy prothrombin and low serum α-fetoprotein have lesions of large size but only a single or a relatively small number of lesions.
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P53 tumor suppressor gene mutations in hepatocellular carcinoma patients in India (pages 1565–1573)Sanjay Katiyar, Bipin C. Dash, Varsha Thakur, Raj C. Guptan, Shiv K. Sarin and Bhudev C. Das
Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000401)88:7<1565::AID-CNCR10>3.0.CO;2-9
Occurrence of a low frequency of p53 mutations and an extremely high frequency of hepatitis B virus (HBV) infection in hepatocellular carcinomas (HCCs) in India, where exposure to dietary aflatoxin B1 also is very high, suggests that HBV infection and aflatoxin B1 may be responsible for the pathogenesis of HCC in India.
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Transcatheter arterial chemoembolization therapy using iodized oil for patients with unresectable hepatocellular carcinoma : Evaluation of three kinds of regimens and analysis of prognostic factors (pages 1574–1581)Kazuto Ueno, Nobuaki Miyazono, Hiroki Inoue, Hirotoshi Nishida, Ichiro Kanetsuki and Masayuki Nakajo
Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000401)88:7<1574::AID-CNCR11>3.0.CO;2-8
Multivariate analysis indicated that significantly important prognostic factors in patients with hepatocellular carcinoma (in order) were extrahepatic metastasis followed by transcatheter arterial chemoembolization, serum α-fetoprotein levels, and portal vein involvement.
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Hepatoid carcinoma of the pancreas (pages 1582–1589)Gladell P. Paner, Karen S. Thompson and Cesar V. Reyes
Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000401)88:7<1582::AID-CNCR12>3.0.CO;2-A
Common embryologic foregut derivation of the pancreas and liver and cellular phenotypic transformation (i.e., hepatocytic transdifferentiation of pancreatic cells) may explain the phenomenon of hepatoid carcinoma of the pancreas.
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Atypical bronchopulmonary carcinoids show a tendency toward increased apoptotic and proliferative activity (pages 1590–1598)Katja L. J. Laitinen, Ylermi Soini, Jorma Mattila and Paavo Pääkkö
Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000401)88:7<1590::AID-CNCR13>3.0.CO;2-C
The apoptotic death rate and proliferative activity in bronchopulmonary carcinoid tumors are both low. Some atypical carcinoids with increased apoptotic activity are associated with shortened survival, clearly deviating from typical carcinoids.
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Cerebrospinal fluid lactate dehydrogenase isoenzyme analysis for the diagnosis of central nervous system involvement in hematooncologic patients (pages 1599–1604)Izidore S. Lossos, Raphael Breuer, Orna Intrator and Alexander Lossos
Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000401)88:7<1599::AID-CNCR14>3.0.CO;2-J
Analysis of lactate dehydrogenase (LDH) isoenzyme pattern in cerebrospinal fluid (CSF) may be helpful in the evaluation of central nervous system involvement in hematooncologic patients. The combination of CSF cytology and LDH isoenzyme analysis may improve the sensitivity of CSF cytology significantly.
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Perineural spread of basal cell carcinomas treated with Mohs micrographic surgery (pages 1605–1613)Désirée Ratner, Lori Lowe, Timothy M. Johnson and Darrell J. Fader
Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000401)88:7<1605::AID-CNCR15>3.0.CO;2-Y
This prospective evaluation of a population of patients with high risk basal cell carcinoma treated with Mohs micrographic surgery indicates that the incidence of perineural invasion is higher than previously recognized. Perineural invasion appears to correlate with the presence of local tumor aggressiveness.
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Growth inhibitory effects of paclitaxel on human epithelioid sarcoma in vitro : Heterogeneity of response and the multidrug resistance phenotype (pages 1614–1622)Petra Reinecke, Christiane Knopf, Michael Schmitz, Eva M. Schneider, Helmut E. Gabbert and Claus D. Gerharz
Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000401)88:7<1614::AID-CNCR16>3.0.CO;2-X
Paclitaxel effectively inhibits the growth of the human epithelioid sarcoma cell line GRU-1 and its clonal subpopulations. However, in the current study the differential response of GRU-1 and its clonal subpopulations to paclitaxel could not be predicted by the expression and function of P-glycoprotein and the multidrug resistance-associated protein.
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Clinical implication of altered expression of Mad1 protein in human breast carcinoma (pages 1623–1632)Sehwan Han, Kyeongmee Park, Hong-Yong Kim, Myung-Soo Lee, Hong-Joo Kim, Young-Duck Kim, Young Jin Yuh, Sung Rok Kim and Hyun Suk Suh
Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000401)88:7<1623::AID-CNCR17>3.0.CO;2-W
Mad1 protein expression was inversely correlated with Myc expression in primary breast carcinoma. Reduced expression of Mad1 protein was associated with increased recurrence after systemic adjuvant chemotherapy.
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Primary axillary radiotherapy as axillary treatment in breast-conserving therapy for patients with breast carcinoma and clinically negative axillary lymph nodes (pages 1633–1642)Frank J. P. Hoebers, Jacques H. Borger, Augustinus A. M. Hart, Johannes L. Peterse, Emiel J. Th. Rutgers and Joos V. Lebesque
Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000401)88:7<1633::AID-CNCR18>3.0.CO;2-S
In this clinical series, primary axillary radiotherapy for early stage breast carcinoma in patients with clinically negative axillary lymph nodes resulted in low rates of axillary recurrence. The incidence rate of late complications after axillary radiotherapy was low and appeared favorable when compared with axillary lymph node dissection.
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Outcomes and factors impacting local recurrence of ductal carcinoma in situ (pages 1643–1649)Elaine Y. Weng, Guy J. F. Juillard, Robert G. Parker, Helena R. Chang and Jeffrey A. Gornbein
Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000401)88:7<1643::AID-CNCR19>3.0.CO;2-O
In the management of ductal carcinoma in situ, if surgical margins are tumor free, wide local excision and radiation therapy are equivalent to mastectomy for local tumor control. In the current study, no subgroup of patients was found who were eligible to be treated with surgery alone.
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Human tumor growth is inhibited by a vaccinia virus carrying the E2 gene of bovine papillomavirus (pages 1650–1662)Viviana Valadez Graham, Gerd Sutter, Marco V. José, Alejandro García-Carranca, Volker Erfle, Norma Moreno Mendoza, Horacio Merchant and Ricardo Rosales
Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000401)88:7<1650::AID-CNCR20>3.0.CO;2-L
Modified vaccinia virus Ankara (MVA), which expresses the E2 gene of bovine papillomavirus, can stop tumor growth by repressing the expression of E6 and E7 papilloma proteins and also by inducing apoptosis in the transformed cells.
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Cancer heterogeneity and its biologic implications in the grading of urothelial carcinoma (pages 1663–1670)Liang Cheng, Roxann M. Neumann, Ajay Nehra, Bruce E. Spotts, Amy L. Weaver and David G. Bostwick
Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000401)88:7<1663::AID-CNCR21>3.0.CO;2-8
Histologic grading of urothelial carcinoma based on the newly proposed World Health Organization and International Society of Urologic Pathology (WHO/ISUP) grading system stratifies patients into prognostically significant groups. Grading should also take cancer heterogeneity into consideration, and prognostic accuracy appears to be increased when the combined primary and secondary grades are applied.
See also pages 1509–12 and 1513–6.
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Ifosfamide, paclitaxel, and cisplatin for patients with advanced transitional cell carcinoma of the urothelial tract : Final report of a Phase II trial evaluating two dosing schedules (pages 1671–1678)Dean F. Bajorin, John A. McCaffrey, Paul M. Dodd, Susan Hilton, Madhu Mazumdar, W. Kevin Kelly, Harry Herr, Howard I. Scher, Evelyn Icasiano and Geralyn Higgins
Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000401)88:7<1671::AID-CNCR22>3.0.CO;2-A
The three-drug regimen of ifosfamide, paclitaxel, and cisplatin is active in the treatment of patients with transitional cell carcinoma. In 44 assessable patients, the overall response was 68%, the complete response was 23%, and the median survival was 20 months.
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Squamous papilloma of the urinary tract is unrelated to condyloma acuminata (pages 1679–1686)Liang Cheng, Bradley C. Leibovich, John C. Cheville, Dharamdas M. Ramnani, Thomas J. Sebo, Ajay Nehra, Reza S. Malek, Horst Zincke and David G. Bostwick
Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000401)88:7<1679::AID-CNCR23>3.0.CO;2-K
Squamous papilloma of the urinary tract is a distinct entity not related to condyloma or verrucous carcinoma. These lesions are benign, negative for human papillomavirus DNA, and DNA diploid, and they lack p53 overaccumulation.
General Topic
Follow-Up of Patients Treated for Cancer
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Grading of late effects in young adult survivors of childhood cancer followed in an ambulatory adult setting (pages 1687–1695)Kevin C. Oeffinger, Debra A. Eshelman, Gail E. Tomlinson, George R. Buchanan and Barbara M. Foster
Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000401)88:7<1687::AID-CNCR24>3.0.CO;2-M
Late effects are common (with one-third being moderate to severe) in young adult survivors of childhood cancer who are followed longitudinally. Further studies are needed to modify the second version of the Common Toxicity Criteria and validate it for use in long term survivors of childhood cancer.
HIV-Related Non-Hodgkin Lymphoma
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Prognostic factors after non-Hodgkin lymphoma in patients infected with the human immunodeficiency virus : Aquitaine cohort, France, 1986–1997 (pages 1696–1702)Frantz Thiessard, Philippe Morlat, Catherine Marimoutou, Eric Labouyrie, Jean-Marie Ragnaud, Jean-Luc Pellegrin, Michel Dupon and François Dabis, the Groupe d'Epidémiologie Clinique du SIDA en Aquitaine (GECSA)
Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000401)88:7<1696::AID-CNCR25>3.0.CO;2-L
The authors described the survival of 101 patients infected with the human immunodeficiency virus (HIV) followed in the Aquitaine Cohort (southwestern France) after the diagnosis of non-Hodgkin lymphoma (NHL). They individualized 4 independent favorable prognostic factors for survival: CD4+ lymphocyte count > 50/mm3, hemoglobinemia > 10 g/dL, Ann Arbor Stages I–III disease, and antiretroviral therapy after the diagnosis of NHL, mostly protease inhibitors that had already, although recently introduced, been reported to improve the survival of HIV-infected patients with NHL dramatically.
Metastatic Melanoma: Phase II Clinical Trial
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A Phase II study of “decrescendo” interleukin-2 plus interferon-α-2a in patients with progressive metastatic melanoma after chemotherapy (pages 1703–1709)Omar Eton, Antonio C. Buzaid, Agop Y. Bedikian, Teresa M. Smith, Nicholas E. Papadopoulos, Julie A. Ellerhorst, Janelle L. Hibberts, Sewa S. Legha and Robert S. Benjamin
Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000401)88:7<1703::AID-CNCR26>3.0.CO;2-X
The response rate for intravenous recombinant human interleukin-2 administered in a “decrescendo” schedule with subcutaneous interferon-α-2a in patients with metastatic melanoma previously treated with chemotherapy is no greater than 10% with Type I and II errors not exceeding 10% each.
Pediatric Oncology
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Feasibility of oral ciprofloxacin for the outpatient management of febrile neutropenia in selected children with cancer (pages 1710–1714)Victor M. Aquino, Larry Herrera, Eric S. Sandler and George R. Buchanan
Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000401)88:7<1710::AID-CNCR27>3.0.CO;2-1
Forty-five selected children with chemotherapy-induced neutropenia who developed fever were treated on an outpatient basis using oral ciprofloxacin. Forty children (89%) were managed safely without the need for hospitalization. The authors conclude that very carefully selected, low risk patients with febrile neutropenia may be treated successfully without hospitalization using oral ciprofloxacin.
Quality of Life
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Measuring quality of life of Chinese cancer patients : A validation of the Chinese version of the functional assessment of cancer therapy–general (FACT-G) scale (pages 1715–1727)Clara L. M. Yu, Richard Fielding, Cecelia L. W. Chan, Vincent K. C. Tse, Peter H. K. Choi, W. H. Lau, Damon T. K. Choy, S. K. O, Anne W. M. Lee and Jonathan S. T. Sham
Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000401)88:7<1715::AID-CNCR28>3.0.CO;2-K
This article describes the preliminary validation of a Chinese translation of the FACT-G, including data on cultural equivalence and basic psychometrics from a large cohort of Chinese cancer patients.
Upper Aerodigestive Tract
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Cancers of the upper aerodigestive tract in Ontario, Canada, and the United States (pages 1728–1738)David P. Skarsgard, Patti A. Groome, William J. Mackillop, Sam Zhou, Deanna Rothwell, Peter F. Dixon, Brian O'Sullivan, Steven F. Hall and Eric J. Holowaty
Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000401)88:7<1728::AID-CNCR29>3.0.CO;2-7
There are remarkable similarities in the case mix of upper aerodigestive tract cancers between the Canadian province of Ontario and the SEER population of the United States, but their incidence is generally higher in the U.S. than in Ontario. There are significant differences in outcome between the two countries.
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