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Cancer

Cover image for Cancer

1 May 2000

Volume 88, Issue 9

Pages 1979–2197

  1. Original Articles

    1. Top of page
    2. Original Articles
    3. Correspondence
    1. Anatomic Site

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      Chemotherapy for the treatment of patients with primary high grade gastric B-cell lymphoma of modified Ann Arbor stages IE and IIE (pages 1979–1985)

      Markus Raderer, Julia Valencak, Christian Österreicher, Johannes Drach, Michael Hejna, Gabriela Kornek, Werner Scheithauer, Thomas Brodowicz, Andreas Chott and Brigitte Dragosics

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000501)88:9<1979::AID-CNCR1>3.0.CO;2-L

      Chemotherapy using the CHOP regimen (doxorubicin, cyclophosphamide, vincristine, and prednisone) is highly effective in the treatment of patients with primary high grade gastric lymphoma of modified Ann Arbor Stages IE and IIE, and offers the potential for conservation of the stomach, even in very elderly patients.

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      Combined therapy consisting of intraarterial cisplatin infusion and systemic interferon-α for hepatocellular carcinoma patients with major portal vein thrombosis or distant metastasis (pages 1986–1991)

      Young-Hwa Chung, Il Han Song, Byung-Cheol Song, Geun Chan Lee, Moon Soo Koh, Hyum-Ki Yoon, Yung Sang Lee, Kyu-Bo Sung and Dong Jin Suh

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000501)88:9<1986::AID-CNCR2>3.0.CO;2-I

      Combined therapy consisting of intraarterial cisplatin infusion and systemic interferon-α may be useful as a palliative treatment for hepatocellular carcinoma patients with major portal vein thrombosis or distant metastasis.

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      Increased expression of N-myristoyltransferase in gallbladder carcinomas (pages 1992–1999)

      Raju V. S. Rajala, Jasim M. Radhi, Rakesh Kakkar, Raju S. S. Datla and Rajendra K. Sharma

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000501)88:9<1992::AID-CNCR3>3.0.CO;2-G

      Tumors with increased expression of N-myristoyltransferase (NMT) and mutant p53 were associated with poor clinical outcome as evidenced by their mean survival times. In patients with gallbladder carcinoma, NMT is likely to play a pathogenic role.

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      Medroxyprogesterone acetate inhibits human pancreatic carcinoma cell growth by inducing apoptosis in association with Bcl-2 phosphorylation (pages 2000–2009)

      Michio Abe, Jun-ichi Yamashita and Michio Ogawa

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000501)88:9<2000::AID-CNCR4>3.0.CO;2-B

      Clinically attainable concentrations of medroxyprogesterone acetate inhibit the growth of some human pancreatic carcinoma cells in vitro by inducing apoptosis, probably through their progesterone receptor, in association with phosphorylation of bcl-2, indicating that it may be useful for the treatment of human pancreatic carcinoma.

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      Characterization of a newly established human pancreatic carcinoma cell line, UK Pan-1 (pages 2010–2021)

      Kimberly D. Fralix, Mansoor M. Ahmed, Cynthia Mattingly, Carol Swiderski, Patrick C. McGrath, Kolaparthi Venkatasubbarao, Nanao Kamada, Mohammed Mohiuddin, William E. Strodel and James W. Freeman

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000501)88:9<2010::AID-CNCR5>3.0.CO;2-5

      A highly tumorigenic and growth factor independent cell line designated as UK Pan-1 was established from a surgically removed human pancreatic adenocarcinoma. Characterization of UK Pan-1 cells revealed a molecularly complex pattern of mutations and a loss of expression of transforming growth factor-β receptor, qualifying this cell line as a useful model to further the understanding of the mechanisms responsible for the development and progression of pancreatic carcinoma.

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      Giant cell tumor of the bones of the hand and foot (pages 2022–2032)

      Roberto Biscaglia, Patrizia Bacchini and Franco Bertoni

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000501)88:9<2022::AID-CNCR6>3.0.CO;2-Y

      This report of the experience of the Rizzoli Orthopedic Institute with 29 patients who had giant cell tumors of the bones of the hand and foot confirms the predominance of such tumors in females and patients of younger age and the more aggressive behavior compared with giant cell tumors in other locations. Radiographic overlapping is common in giant cell rich lesions of the bones of the hand and foot, and histology is the most important diagnostic tool.

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      Prospective randomized comparison of morning versus night daily single subcutaneous administration of granulocyte-macrophage–colony stimulating factor in patients with soft tissue or bone sarcoma (pages 2033–2036)

      Dilek Dinçol, Mustafa Samur, Ali Pamir, Orhan Şencan, Hakan Akbulut, Bülent Yalçın, Handan Onur, Ahmet Demirkazık, Filiz Çay Şenler and Fikri İçli

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000501)88:9<2033::AID-CNCR7>3.0.CO;2-R

      Considering the circadian rhythm of the hematopoietic growth factors, the effect of the timing of granulocyte-macrophage–colony stimulating factor administration (morning vs. night) on hematologic recovery was evaluated in 47 chemotherapy cycles. The mean duration of Grade 3–4 neutropenia was shorter in the morning treatment arm (5.3 ± 0.4 vs. 6.5 ± 0.3 days, P = 0.017), but there were no differences related to the number of febrile neutropenic episodes or the duration of antibiotic administration.

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      Treatment of patients with recurrent and primary refractory acute myelogenous leukemia using mitoxantrone and intermediate-dose cytarabine : A pharmacologically based regimen (pages 2037–2041)

      David W. Sternberg, William Aird, Donna Neuberg, Lynn Thompson, Kimberly MacNeill, Philip Amrein and Lawrence N. Shulman

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000501)88:9<2037::AID-CNCR8>3.0.CO;2-K

      Patients with recurrent or refractory acute myelogenous leukemia were treated with intermediate-dose cytarabine, 500 mg/m2, every 12 hours × 12 doses, and mitoxantrone, 5 mg/m2/day × 5 days. The complete remission rate for these patients was 62% and the regimen was well tolerated, including in elderly patients.

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      High dose inhalation interleukin-2 therapy for lung metastases in patients with malignant melanoma (pages 2042–2046)

      Alexander H. Enk, Dorothee Nashan, Albert Rübben and Jürgen Knop

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000501)88:9<2042::AID-CNCR9>3.0.CO;2-J

      The current study reports successful regional treatment of lung metastases in patients with metastatic melanoma who were treated with inhalant interleukin-2.

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      Effects of high dose raloxifene in selected patients with advanced breast carcinoma (pages 2047–2053)

      William Gradishar, Joan Glusman, Yili Lu, Charles Vogel, Fredric J. Cohen and George W. Sledge Jr.

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000501)88:9<2047::AID-CNCR10>3.0.CO;2-E

      Raloxifene HCl (150 mg administered twice daily) demonstrated low toxicity and modest antitumor activity in postmenopausal women with metastatic or locoregionally recurrent, originally estrogen receptor positive breast carcinoma who had not received prior systemic treatment of metastatic disease.

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      Combined modality treatment of locally advanced breast carcinoma in elderly patients or patients with severe comorbid conditions using tamoxifen as the primary therapy (pages 2054–2060)

      Paulo M. Hoff, Vicente Valero, Aman U. Buzdar, S. Eva Singletary, Richard L. Theriault, Daniel Booser, Lina Asmar, Debra Frye, Marsha D. McNeese and Gabriel N. Hortobagyi

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000501)88:9<2054::AID-CNCR11>3.0.CO;2-J

      In elderly or frail patients with locally advanced estrogen receptor positive breast carcinoma, neoadjuvant tamoxifen has been found to be an effective treatment option with a reasonable response rate, including complete responses and good overall survival.

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      Expression of interleukin-6, interleukin-6 receptor, and glycoprotein 130 correlates with good prognoses for patients with breast carcinoma (pages 2061–2071)

      Aldona Karczewska, Sergiusz Nawrocki, Danuta Brȩborowicz, Violetta Filas and Andrzej Mackiewicz

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000501)88:9<2061::AID-CNCR12>3.0.CO;2-O

      mRNA expression of interleukin-6 and its receptor subunits in breast carcinoma tissue correlates with earlier stages of the disease and is a good prognostic factor.

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      Genetic abnormalities in mammary ductal intraepithelial neoplasia-flat type (“clinging ductal carcinoma in situ”) : A simulator of normal mammary epithelium (pages 2072–2081)

      Farid Moinfar, Yan-Gao Man, Gary L. Bratthauer, Manfred Ratschek and Fattaneh A. Tavassoli

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000501)88:9<2072::AID-CNCR13>3.0.CO;2-H

      Breast epithelial cells that appear in architecturally normal ducts contain genetic alterations similar to those observed in association with in situ and invasive breast tumors. On further examination, these normal-appearing cells are shown to exhibit subtle cytologic changes differentiating them from cytologically normal cells and may represent the first phenotypic indicator of breast carcinogenesis.

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      Combined analysis of germline polymorphisms of p53, GSTM1, GSTT1, CYP1a1, and CYP2e1 : Relation to the incidence rate of cervical carcinoma (pages 2082–2091)

      Jin W. Kim, Chun G. Lee, Yong G. Park, Kyung S. Kim, In-K. Kim, Yeo W. Sohn, Hong K. Min, Joon M. Lee and Sung E. Namkoong

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000501)88:9<2082::AID-CNCR14>3.0.CO;2-D

      The arginine/proline genotype of p53, independently or in conjunction with the GSTT1 null genotype, affects the genetic susceptibility of human papillomavirus positive cervical carcinoma.

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      Thiol-mediated apoptosis in prostate carcinoma cells (pages 2092–2104)

      Ronan N. T. Coffey, R. William G. Watson, Nicholas J. Hegarty, Amanda O'Neill, Norma Gibbons, Hugh R. Brady and John M. Fitzpatrick

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000501)88:9<2092::AID-CNCR15>3.0.CO;2-9

      Thiol depletion of glutathione through diethylmaleate leads to the direct activation of caspase-3 and apoptotic induction in both androgen sensitive and insensitive prostate carcinoma cells. Direct activation of this downstream effector caspase is independent of the overexpression of Bcl-2 and may prove an effective strategy for inducing apoptosis in prostate carcinoma cells.

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      The use of artificial intelligence technology to predict lymph node spread in men with clinically localized prostate carcinoma (pages 2105–2109)

      E. David Crawford, Joseph T. Batuello, Peter Snow, Eduard J. Gamito, David G. McLeod, Alan W. Partin, Nelson Stone, James Montie, Richard Stock, John Lynch and Jeff Brandt

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000501)88:9<2105::AID-CNCR16>3.0.CO;2-3

      Artificial intelligence methods can be used to predict accurately the low risk of lymph node spread in men with clinically localized prostate carcinoma.

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      Prostate specific antigen outcome based on the extent of extracapsular extension and margin status in patients with seminal vesicle negative prostate carcinoma of Gleason score ≤ 7 (pages 2110–2115)

      Anthony V. D'Amico, Richard Whittington, S. Bruce Malkowicz, Delray Schultz, John E. Tomaszewski and Alan Wein

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000501)88:9<2110::AID-CNCR17>3.0.CO;2-E

      Patients with specimen confined focal or established extracapsular extension or margin positive prostate carcinoma who also have a prostatectomy Gleason score of ≤ 7 and no evidence of seminal vesicle invasion may benefit from adjuvant postoperative radiation therapy.

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      Long term survivors of childhood brain cancer have an increased risk for cardiovascular disease (pages 2116–2121)

      Janneke Heikens, Mathilde C. Ubbink, Heleen P. J. van der Pal, Piet J. M. Bakker, Eric Fliers, Tineke J. Smilde, John J. P. Kastelein and Mieke D. Trip

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000501)88:9<2116::AID-CNCR18>3.0.CO;2-U

      The risk for cardiovascular disease is greatly increased, for long term survivors of brain cancer, particularly those with growth hormone deficiency. In this study, the first effects of this increased risk for cardiovascular disease were observed in the carotid bulb, as assessed by carotid intima-media thickness measurements.

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      Prognostic factors in chordoma of the sacrum and mobile spine : A study of 39 patients (pages 2122–2134)

      Peter Bergh, Lars-Gunnar Kindblom, Björn Gunterberg, Fabrizio Remotti, Walter Ryd and Jeanne M. Meis-Kindblom

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000501)88:9<2122::AID-CNCR19>3.0.CO;2-1

      Modern surgical techniques enabling complete removal of sacral and spinal chordomas result in significant improvement in local tumor control and patient survival, and a decrease in long term complications.

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      The role of lung perfusion imaging in predicting the direction of radiation-induced changes in pulmonary function tests (pages 2135–2141)

      Lawrence B. Marks, Donna Hollis, Michael Munley, Gunilla Bentel, Melahat Garipagaoglu, Ming Fan, Jeanne Poulson, Robert Clough, Gregory Sibley, R. Edward Coleman and Ronald Jaszczak

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000501)88:9<2135::AID-CNCR20>3.0.CO;2-H

      The pattern of intrathoracic blood flow prior to radiation therapy can be used to identify patients likely to have an improvement in their diffusion capacity following radiation therapy.

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      Hybrid chemotherapy consisting of cyclophosphamide, vincristine, procarbazine, prednisone, doxorubicin, bleomycin, and vinblastine (C-MOPP/ABV) as first-line treatment for patients with advanced hodgkin disease (pages 2142–2148)

      Silvia Montoto, Mireia Camós, Armando López-Guillermo, Francesc Bosch, Francisco Cervantes, Joan Bladé, Jordi Esteve, Francesc Cobo, Benet Nomdedeu, Elías Campo and Emilio Montserrat

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000501)88:9<2142::AID-CNCR21>3.0.CO;2-M

      Hybrid chemotherapy consisting of cyclophosphamide, vincristine, procarbazine, prednisone, doxorubicin, bleomycin, and vinblastine (C-MOPP/ABV) as first-line treatment for patients with advanced Hodgkin disease induces a high complete response rate with acceptable toxicity, especially in young patients.

    22. General Topic

      Chemotherapy: Cardiotoxicity
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      Impairment of heart rate variability during paclitaxel therapy (pages 2149–2153)

      Eeva M. K. Ekholm, Eeva K. Salminen, Heikki V. Huikuri, Jarmo Jalonen, Kari J. Antila, Tuula A. Salmi and Virpi T. Rantanen

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000501)88:9<2149::AID-CNCR22>3.0.CO;2-Z

      In the current study, autonomic modulation of the heart rate was found to be impaired after two courses of paclitaxel therapy.

    23. Gynecologic Cancer Detection by Tumor Markers
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      Synucleins are expressed in the majority of breast and ovarian carcinomas and in preneoplastic lesions of the ovary (pages 2154–2163)

      Wendy Bruening, Benoit I. Giasson, Andres J. P. Klein-Szanto, Virginia M.-Y. Lee, John Q. Trojanowski and Andrew K. Godwin

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000501)88:9<2154::AID-CNCR23>3.0.CO;2-9

      α, β, and γ synuclein are expressed in a high percentage of ovarian and breast carcinomas, and abnormal γ synuclein expression may be a biomarker of impending ovarian carcinoma.

    24. Palliative Care
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      Validation of the Edmonton Symptom Assessment Scale (pages 2164–2171)

      Victor T. Chang, Shirley S. Hwang and Martin Feuerman

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000501)88:9<2164::AID-CNCR24>3.0.CO;2-5

      The Edmonton Symptom Assessment Scale is a valid symptom assessment instrument in a general medical oncology population, and the “distress” score tends to reflect physical symptoms. Test-retest reliability is better at 2 days than at 1 week.

    25. Pediatric Oncology
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      Bone sarcomas of the head and neck in children : The St. Jude Children's Research Hospital experience (pages 2172–2180)

      Najat C. Daw, Hazem H. Mahmoud, William H. Meyer, Jesse J. Jenkins, Sue C. Kaste, Catherine A. Poquette, Larry E. Kun, Charles B. Pratt and Bhaskar N. Rao

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000501)88:9<2172::AID-CNCR25>3.0.CO;2-7

      Bone sarcomas originating in the head and neck are rare among children and most often are localized at the time of diagnosis. Incomplete surgical resection of osteosarcoma is associated with local failure and poor outcome.

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      Primary chondrosarcoma of the head and neck in pediatric patients : A clinicopathologic study of 14 cases with a review of the literature (pages 2181–2188)

      Shyam R. Gadwal, Julie C. Fanburg-Smith, Francis H. Gannon and Lester D. R. Thompson

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000501)88:9<2181::AID-CNCR26>3.0.CO;2-6

      Chondrosarcoma of the head and neck in pediatric patients usually involves the maxillary sinus and portends a good prognosis despite invasive growth or high grade histology.

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      Outcome for children with supratentorial primitive neuroectodermal tumors treated with surgery, radiation, and chemotherapy (pages 2189–2193)

      Alyssa T. Reddy, Anna J. Janss, Peter C. Phillips, Heidi L. Weiss and Roger J. Packer

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000501)88:9<2189::AID-CNCR27>3.0.CO;2-G

      In a prospective study, children with supratentorial primitive neuroectodermal tumors were treated with surgery, craniospinal radiation, and chemotherapy (comprised of cisplatin, vincristine, and lomustine) utilizing protocols also used to treat patients with high risk medulloblastoma. The outcome for these patients was poor, with a 5-year progression free survival of only 37%.

  2. Correspondence

    1. Top of page
    2. Original Articles
    3. Correspondence
    1. General Topic

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    2. You have free access to this content
      Author reply (page 2195)

      Leonard B. Saltz

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000501)88:9<2195::AID-CNCR29>3.0.CO;2-L

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      Author reply (pages 2196–2197)

      Michael Froehner, Rainer Fischer and Manfred P. Wirth

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(20000501)88:9<2196::AID-CNCR31>3.0.CO;2-4

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