Dr. Rao obtained his medical degree from Grant Medical College in India and his Ph.D. from Caltech. He is currently an Assistant Professor at the University of Utah Medical School. His laboratory focus continues to be neural stem cell biology.
Multipotent and restricted precursors in the central nervous system
Article first published online: 7 DEC 1999
Copyright © 1999 Wiley-Liss, Inc.
The Anatomical Record
Volume 257, Issue 4, pages 137–148, 15 August 1999
How to Cite
Rao, M. S. (1999), Multipotent and restricted precursors in the central nervous system. Anat. Rec., 257: 137–148. doi: 10.1002/(SICI)1097-0185(19990815)257:4<137::AID-AR7>3.0.CO;2-Q
- Issue published online: 26 DEC 2002
- Article first published online: 7 DEC 1999
- stem cell;
- neuronal stem cell;
Acquisition of cell type-specific properties in the nervous system is likely a process of sequential restriction in developmental potential. At least two classes of pluripotent stem cells, neuroepithelial (NEP) stem cells and EGF-dependent neurosphere stem cells, have been identified in distinct spatial and temporal domains. Pluripotent stem cells likely generate central nervous system (CNS) and peripheral nervous system (PNS) derivatives via the generation of intermediate lineage-restricted precursors that differ from each other and from multipotent stem cells. Neuronal precursors termed neuronal-restricted precursors (NRPs), multiple classes of glial precursors termed glial-restricted precursors (GRPs), oligodendrocyte-type 2 astrocytes (O2As), astrocyte precursor cells (APCs), and PNS precursors termed neural crest stem cells (NCSCs) have been identified. Multipotent stem cells and restricted precursor cells can be isolated from embryonic stem (ES) cell cultures providing a non-fetal source of such cells. Analysis in multiple species illustrates similarities between rat, mouse, and human cell differentiation raising the possibility that similar factors and markers may be used to isolate precursor cells from human tissue or ES cells. Anat Rec (New Anat): 257:137–143, 1999. © 1999 Wiley-Liss, Inc.