Measuring phase synchrony in brain signals
Article first published online: 30 NOV 1999
Copyright © 1999 Wiley-Liss, Inc.
Human Brain Mapping
Volume 8, Issue 4, pages 194–208, 1999
How to Cite
Lachaux, J.-P., Rodriguez, E., Martinerie, J. and Varela, F. J. (1999), Measuring phase synchrony in brain signals. Hum. Brain Mapp., 8: 194–208. doi: 10.1002/(SICI)1097-0193(1999)8:4<194::AID-HBM4>3.0.CO;2-C
- Issue published online: 30 NOV 1999
- Article first published online: 30 NOV 1999
- Manuscript Accepted: 17 MAY 1999
- Manuscript Received: 13 MAR 1998
- Human Science Frontier
- neural synchrony;
This article presents, for the first time, a practical method for the direct quantification of frequency-specific synchronization (i.e., transient phase-locking) between two neuroelectric signals. The motivation for its development is to be able to examine the role of neural synchronies as a putative mechanism for long-range neural integration during cognitive tasks. The method, called phase-locking statistics (PLS), measures the significance of the phase covariance between two signals with a reasonable time-resolution (<100 ms). Unlike the more traditional method of spectral coherence, PLS separates the phase and amplitude components and can be directly interpreted in the framework of neural integration. To validate synchrony values against background fluctuations, PLS uses surrogate data and thus makes no a priori assumptions on the nature of the experimental data. We also apply PLS to investigate intracortical recordings from an epileptic patient performing a visual discrimination task. We find large-scale synchronies in the gamma band (45 Hz), e.g., between hippocampus and frontal gyrus, and local synchronies, within a limbic region, a few cm apart. We argue that whereas long-scale effects do reflect cognitive processing, short-scale synchronies are likely to be due to volume conduction. We discuss ways to separate such conduction effects from true signal synchrony. Hum Brain Mapping 8:194–208, 1999. © 1999 Wiley-Liss, Inc.