Bone mass and body composition after cessation of therapy for childhood cancer
Article first published online: 25 MAR 1999
Copyright © 1998 Wiley-Liss, Inc.
International Journal of Cancer
Supplement: Nutritional Morbidity in Children With Cancer: Mechanisms, Measures & Management
Volume 78, Issue Supplement 11, pages 40–43, 1998
How to Cite
Nysom, K., Mølgaard, C., Holm, K., Hertz, H. and Fleischer Michaelsen, K. (1998), Bone mass and body composition after cessation of therapy for childhood cancer. Int. J. Cancer, 78: 40–43. doi: 10.1002/(SICI)1097-0215(1998)78:11+<40::AID-IJC12>3.0.CO;2-H
- Issue published online: 25 MAR 1999
- Article first published online: 25 MAR 1999
- Torkil Steenbeck Foundation
- Ville Heise Foundation
- Rosalie Petersen Foundation
- FØTEK (Food Technology Research and Development Programme
- Danish Dairy Research Foundation
Our aim was to review current information on body composition and bone mass after cessation of therapy for childhood cancer and to present preliminary data on body composition and bone mass in a group of Danish survivors of childhood leukaemia or lymphoma. Elevated body-mass index (weight/height2; BMI) is frequent after treatment for childhood acute lymphoblastic leukaemia. BMI increases during therapy or within the first year after therapy and remains abnormal thereafter. Treatment with corticosteroids, abnormal growth-hormone secretion after treatment with cranial irradiation (CI) or corticosteroids, younger age at diagnosis, or female gender were risk factors for elevated BMI in earlier studies. We evaluated 185 survivors of childhood leukaemia or lymphoma by dual-energy X-ray absorptiometry scanning. We found elevated whole-body relative fat mass, which was associated with CI. Other studies found reduced bone mass in the radius, the lumbar spine and the whole body after treatment for childhood cancer. Growth-hormone deficiency that is not adequately corrected, CI, reduced height or reduced weight were risk factors for reduced bone mass. In our 185 participants, the whole-body bone mass was also reduced significantly compared with reference values. CI and older age at follow-up were risk factors for reduced bone mass. We conclude that the elevated relative fat mass and reduced bone mass seen after treatment for childhood leukaemia or lymphoma is associated mainly with CI. Int. J. Cancer Supplement 11: 40–43, 1998. © 1998 Wiley-Liss, Inc.