Diabetes and endometrial cancer: An Italian case-control study
Article first published online: 8 NOV 1999
Copyright © 1999 Wiley-Liss, Inc.
International Journal of Cancer
Volume 81, Issue 4, pages 539–542, 17 May 1999
How to Cite
Parazzini, F., La Vecchia, C., Negri, E., Luca Riboldi, G., Surace, M., Benzi, G., Maina, A. and Chiaffarino, F. (1999), Diabetes and endometrial cancer: An Italian case-control study. Int. J. Cancer, 81: 539–542. doi: 10.1002/(SICI)1097-0215(19990517)81:4<539::AID-IJC6>3.0.CO;2-Q
- Issue published online: 8 NOV 1999
- Article first published online: 8 NOV 1999
- Manuscript Revised: 17 NOV 1998
- Manuscript Received: 24 AUG 1998
- Associazione Italiana per la Ricerca sul Cancro
We considered the association between diabetes and risk of endometrial cancer using data from a large case-control study conducted in Italy. Cases were 752 women with incident, histologically confirmed endometrial cancer <75 years of age (median age 60 years, range 28–74) admitted to a network of hospitals in Milan. Controls were 2,606 patients (median age 54 years, range 25–74) aged <75 years, admitted for acute non-neoplastic, non-gynecological, non-hormone-related conditions to the same network of hospitals where cases had been identified. A total of 132 (17.6%) cases and 116 controls (4.5%) reported a history of diabetes. The corresponding multivariate odds ratio (OR) was 2.9 [95% confidence interval (CI) 2.2–3.9]. No association emerged with diabetes diagnosed under age 40 (likely to be insulin-dependent diabetes), whereas the OR of endometrial cancer was 3.1 (95% CI 2.3–4.2) for diabetes diagnosed at age ≥40 years. The OR of endometrial cancer in women with history of diabetes was 3.0 for women with a body mass index (BMI) (QI) kg/m2 <25, 3.6 for those with a BMI of 25–29, and 3.3 for those with a BMI ≥30. No consistent interaction or modifying effect was observed for any other covariate. Our results confirm that non-insulin-dependent diabetes is associated with the risk of endometrial cancer. The association may be mediated through elevated oestrogen levels in diabetic women, hyperinsulinemia or insulin-like growth factor-I (IGF-I).Int. J. Cancer 81:539–542, 1999. © 1999 Wiley-Liss, Inc.