Chlamydia trachomatis infection as a risk factor for invasive cervical cancer
Article first published online: 2 DEC 1999
Copyright © 2000 Wiley-Liss, Inc.
International Journal of Cancer
Volume 85, Issue 1, pages 35–39, 1 January 2000
How to Cite
Koskela, P., Anttila, T., Bjørge, T., Brunsvig, A., Dillner, J., Hakama, M., Hakulinen, T., Jellum, E., Lehtinen, M., Lenner, P., Luostarinen, T., Pukkala, E., Saikku, P., Thoresen, S., Youngman, L. and Paavonen, J. (2000), Chlamydia trachomatis infection as a risk factor for invasive cervical cancer. Int. J. Cancer, 85: 35–39. doi: 10.1002/(SICI)1097-0215(20000101)85:1<35::AID-IJC6>3.0.CO;2-A
- Issue published online: 2 DEC 1999
- Article first published online: 2 DEC 1999
- Manuscript Revised: 11 AUG 1999
- Manuscript Received: 15 APR 1999
- Finnish Cancer Organizations
- Nordic Cancer Union
- Helsinki University Central Hospital
- Nordic Education Academy
Cervical carcinoma is a sexually transmitted disease most strongly linked with human-papillomavirus (HPV) infection. We conducted a prospective sero-epidemiologic study to evaluate the role of Chlamydia trachomatis infection in the development of cervical carcinoma, with invasive cancer as an end point. A nested case-control study within a cohort of 530000 Nordic women was performed. Linking data files of 3 Nordic serum banks and the cancer registries of Finland, Norway and Sweden identified 182 women with invasive cervical carcinoma diagnosed during a mean follow-up of 5 years after serum sampling. The serum samples of the cases and matched cancer-free controls were analyzed for IgG antibodies to C. trachomatis, C. pneumoniae (a control microbe) and HPV types 16, 18 and 33, as well as for serum cotinine (an indicator of tobacco smoking). Serum antibodies to C. trachomatis were associated with an increased risk for cervical squamous-cell carcinoma (HPV- and smoking-adjusted OR, 2.2; 95% CI, 1.3–3.5). The association remained also after adjustment for smoking both in HPV16-seronegative and -seropositive cases (OR, 3.0; 95% CI, 1.8–5.1; OR, 2.3, 95% CI, 0.8–7.0 respectively). No such association was found for C. pneumoniae. Our prospective study provides sero-epidemiologic evidence that infection with C. trachomatis confers an increased risk for subsequent development of invasive squamous-cell carcinoma of the uterine cervix. Int. J. Cancer 85:35–39, 2000. © 2000 Wiley-Liss, Inc.