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Non-melanoma skin cancer may be a marker of poor prognosis in patients with non-Hodgkin's lymphoma

  1. Henrik Hjalgrim1,*,
  2. Morten Frisch1,
  3. Hans H. Storm2,
  4. Bengt Glimelius3,
  5. Jakob Bøje Pedersen1,
  6. Mads Melbye1

Article first published online: 2 MAR 2000

DOI: 10.1002/(SICI)1097-0215(20000301)85:5<639::AID-IJC7>3.0.CO;2-L

Issue

International Journal of Cancer

International Journal of Cancer

Volume 85, Issue 5, pages 639–642, 1 March 2000

Additional Information

How to Cite

Hjalgrim, H., Frisch, M., Storm, H. H., Glimelius, B., Pedersen, J. B. and Melbye, M. (2000), Non-melanoma skin cancer may be a marker of poor prognosis in patients with non-Hodgkin's lymphoma. International Journal of Cancer, 85: 639–642. doi: 10.1002/(SICI)1097-0215(20000301)85:5<639::AID-IJC7>3.0.CO;2-L

Author Information

  1. 1

    Department of Epidemiology Research, Danish Epidemiology Science Centre, Statens Serum Institut, Copenhagen, Denmark

  2. 2

    Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark

  3. 3

    Department of Oncology, Uppsala University Hospital, Uppsala, Sweden

*Danish Epidemiology Science Centre, Statens Serum Institut, 5 Artillerivej, DK-2300 Copenhagen S, Denmark. Fax: +45 32 68 31 65;

Publication History

  1. Issue published online: 2 MAR 2000
  2. Article first published online: 2 MAR 2000
  3. Manuscript Revised: 8 SEP 1999
  4. Manuscript Received: 5 JUL 1999

Funded by

  • Danish Cancer Society. Grant Number: KB 97-100-79)
  • Danish National Research Foundation. Grant Number: Grosserer L.F. Foght's Foundation

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Abstract

According to recent results, patients with non-melanoma skin cancers are at increased risk of developing non-Hodgkin's lymphoma (NHL). The prognostic significance of this association is unknown. Two cohorts of patients with a first diagnosis of non-melanoma skin cancer and a subsequent diagnosis of either NHL (n = 170) or colon cancer (n = 435) were established using national cancer registry data in Denmark. Two other cohorts of patients in whom NHL (n = 600) or colon cancer (n = 1,541) was the patients' first known malignancy served as comparison groups. Mortality rates were compared using Cox's regression analysis. Among patients younger than 80 years at NHL diagnosis, a history of non-melanoma skin cancer was associated with significantly increased mortality [relative risk (RR) = 1.54; 95% confidence interval: 1.19–1.99]. This association was present in both men (RR = 1.38; 1.02–1.86) and women (RR = 2.15; 1.31–3.54) and was similar after both major subtypes of non-melanoma skin cancer. Overall, antedating non-melanoma skin cancer had no prognostic significance for colon cancer patients (RR = 1.00; 0.84–1.18). Whatever the underlying mechanism, our observation has potential clinical implications. If substantiated in other settings, NHL patients with prior non-melanoma skin cancer may constitute a subgroup of lymphoma patients in need of particular therapeutic attention. Int. J. Cancer 85:639–642, 2000. © 2000 Wiley-Liss, Inc.

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