• Bornfeldt, K.E., Campbell, J.S., Koyama, H., Argast, G.M., Leslie, C.C., Raines, E.W., Krebs, E.G. and Ross, R., The mitogen-activated protein kinase pathway can mediate growth inhibition and proliferation in smooth muscle cells. Dependence on the availability of downstream targets. J. Clin. Invest., 100, 875-885 (1997)
  • Boukamp, P., Petrussevska, R.T., Breitkreutz, D., Hornung, J., Markham, A. and Fusenig, N.E., Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J. Cell. Biol., 106, 761-771 (1988).
  • Buckman, S.Y., Gresham, A., Hale, P., Hruza, G., Anast, J., Masferrer, J. and Pentland, A.P., COX-2 expression is induced by UVB exposure in human skin: implications for the development of skin cancer. Carcinogenesis, 19, 723-729 1998).
  • Chinery, R., Beauchamp, R.D., Shyr, Y., Kirkland, S.C., Coffey, R.J. and Morrow, J.D., Antioxidants reduce cyclooxygenase-2 expression, prostaglandin production, and prolifeation in colorectal cancer cells. Cancer Res., 58, 2323-2327 (1998).
  • Dubois, R.N., Shao, J., Tsujii, M., Sheng, H. and Beauchamp, R.D., G1 delay in cells overexpressing prostaglandin endoperoxide synthase-2. Cancer Res., 56, 733-737 (1996).
  • Evans, C.B., Pillai, S. and Goldyne, M.E., Endogenous prostaglandin E2 modulates calcium-induced differentiation in human skin keratinocytes. Prostaglandins Leukot. Essent. Fatty Acids., 49, 777-781 (1993).
  • Herschman, H.R., Prostaglandin synthase 2. Biochim. Biophys. Acta., 1299, 125-140 (1996).
  • Hla, T. and Neilson, K., Human cyclooxygenase-2 cDNA. Proc. Natl. Acad. Sci. U.S.A., 89, 7384-7388 (1992).
  • Kanekura, T., Laulederkind, S.J., Kirtikara, K., Goorha, S. and Ballou, L.R., Cholecalciferol induces prostaglandin Einline image biosynthesis and transglutaminase activity in human keratinocytes. J. Invest. Dermatol., 111, 634-639 1998),
  • Kawamori, T., Rao, C.V., Seibert, K. and Reddy, B.S., Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, against colon carcinogenesis. Cancer Res., 58, 409-412 (1998).
  • Leong, J., Hughes Fulford, M., Rakhlin, N., Habib, A., Maclouf, J. and Goldyne, M.E., Cyclooxygenases in human and mouse skin and cultured human keratinocytes: association of COX-2 expression with human keratinocyte differentiation. Exp. Cell Res., 224, 79-87 (1996).
  • Muller-Decker, K., Kopp Schneider, A., Marks, F., Seibert, K. and Furstenberger, G., Localization of prostaglandin H synthase isoenzymes in murine epidermal tumors: suppression of skin tumor promotion by inhibition of prostaglandin H synthase-2. Mol. Carcinog., 23, 36-44 (1998).
  • Muller-Decker, K., Reinerth, G., Krieg, P., Zimmermann, R., Heise, H., Bayerl, C., Marks, F. and Furstenberger, G., Prostaglandin-H-synthase isozyme expression in normal and neoplastic human skin. Int. J. Cancer, 82, 648-656 (1999).
  • Oshima, M., Dinchuk, J.E., Kargman, S.L., Oshima, H., Hancock, B., Kwong, E., Trzaskos, J.M., Evans, J.F. and Taketo, M.M., Suppression of intestinal polyposis in Apc Δ716 knockout mice by inhibition of cyclooxygenase 2 (COX-2). Cell, 87, 803-809 (1996).
  • Sheng, H., Shao, J., Morrow, J.D., Beauchamp, R.D. and DuBois, R.N., Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells. Cancer Res., 58, 362-366 (1998a).
  • Sheng, H., Williams, C.S., Shao, J., Liang, P., DuBois, R.N. and Beauchamp, R.D., Induction of cyclooxygenase-2 by activated Ha-ras oncogene in Rat-1 fibroblasts and the role of mitogen-activated protein kinase pathway. J. Biol. Chem., 273, 22120-22127 (1998b).
  • Smith, W.L., Garavito, R.M. and DeWitt, D.L., Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2. J. Biol. Chem., 271, 33157-33160 (1996).
  • Subbaramaiah, K., Telang, N., Ramonetti, J.T., Araki, R., DeVito, B., Weksler, B.B. and Dannenberg, A.J., Transcription of cyclooxygenase-2 is enhanced in transformed mammary epithelial cells. Cancer Res., 56, 4424-4429 (1996).
  • Tsujii, M. and DuBois, R.N., Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Cell, 83, 493-501 (1995).
  • Tsujii, M., Kawano, S., Tsuji, S., Sawaoka, H., Hori, M. and DuBois, R.N., Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell, 93, 705-716 (1998).
  • Zimmermann, K.C., Sarbia, M., Weber, A.A., Borchard, F., Gabbert, H.E. and schror, k., Cyclooxygenase-2 expression in human esophageal carcinoma. Cancer Res., 59, 198-204 (1999).