Statistics in Medicine

© John Wiley & Sons, Ltd.

Cover image for Statistics in Medicine

Special Issue: Statistical Issues in Biopharmaceutical Environments: U.S.A. and European Perspectives

15 - 30 August 1998

Volume 17, Issue 15-16

Pages 1661–1892

Issue edited by: Byron Jones

  1. Preface

    1. Top of page
    2. Preface
    3. Research Articles
    4. Discussions
    5. Research Articles
    6. Discussions
    7. Research Articles
    8. Discussions
    9. Research Articles
    10. Discussions
    11. Research Articles
    12. Discussions
    13. Research Articles
    1. Preface (page 1661)

      Byron Jones

      Article first published online: 21 DEC 1998 | DOI: 10.1002/(SICI)1097-0258(19980815/30)17:15/16<1661::AID-SIM968>3.0.CO;2-2

  2. Research Articles

    1. Top of page
    2. Preface
    3. Research Articles
    4. Discussions
    5. Research Articles
    6. Discussions
    7. Research Articles
    8. Discussions
    9. Research Articles
    10. Discussions
    11. Research Articles
    12. Discussions
    13. Research Articles
    1. Statistical shortcomings in licensing applications (pages 1663–1673)

      John A. Lewis and Karen M. Facey

      Article first published online: 21 DEC 1998 | DOI: 10.1002/(SICI)1097-0258(19980815/30)17:15/16<1663::AID-SIM969>3.0.CO;2-U

    2. Methodological advances and plans for improving regulatory success for confirmatory studies (pages 1675–1690)

      Gary G. Koch, Sonia M. Davis and Randy L. Anderson

      Article first published online: 21 DEC 1998 | DOI: 10.1002/(SICI)1097-0258(19980815/30)17:15/16<1675::AID-SIM970>3.0.CO;2-C

    3. Practical issues in equivalence trials (pages 1691–1701)

      A. F. Ebbutt and L. Frith

      Article first published online: 21 DEC 1998 | DOI: 10.1002/(SICI)1097-0258(19980815/30)17:15/16<1691::AID-SIM971>3.0.CO;2-J

    4. Therapeutic equivalence investigations: statistical considerations (pages 1703–1714)

      Joachim Röhmel

      Article first published online: 21 DEC 1998 | DOI: 10.1002/(SICI)1097-0258(19980815/30)17:15/16<1703::AID-SIM972>3.0.CO;2-G

    5. Issues for statisticians in pharmaco-economic evaluations (pages 1715–1723)

      A. P. Grieve

      Article first published online: 21 DEC 1998 | DOI: 10.1002/(SICI)1097-0258(19980815/30)17:15/16<1715::AID-SIM973>3.0.CO;2-6

    6. A forecasting approach to accelerate drug development (pages 1725–1740)

      C. Anthony Hunt, Serge Guzy and Daniel L. Weiner

      Article first published online: 21 DEC 1998 | DOI: 10.1002/(SICI)1097-0258(19980815/30)17:15/16<1725::AID-SIM974>3.0.CO;2-2

  3. Discussions

    1. Top of page
    2. Preface
    3. Research Articles
    4. Discussions
    5. Research Articles
    6. Discussions
    7. Research Articles
    8. Discussions
    9. Research Articles
    10. Discussions
    11. Research Articles
    12. Discussions
    13. Research Articles
    1. Discussion (pages 1741–1743)

      Dr. Jorgen Seldrup

      Article first published online: 21 DEC 1998 | DOI: 10.1002/(SICI)1097-0258(19980815/30)17:15/16<1741::AID-SIM975>3.0.CO;2-9

  4. Research Articles

    1. Top of page
    2. Preface
    3. Research Articles
    4. Discussions
    5. Research Articles
    6. Discussions
    7. Research Articles
    8. Discussions
    9. Research Articles
    10. Discussions
    11. Research Articles
    12. Discussions
    13. Research Articles
    1. Counts and times to events (pages 1745–1751)

      J. K. Lindsey

      Article first published online: 21 DEC 1998 | DOI: 10.1002/(SICI)1097-0258(19980815/30)17:15/16<1745::AID-SIM976>3.0.CO;2-V

    2. Some controversies in planning and analysing multi-centre trials (pages 1753–1765)

      Stephen Senn

      Article first published online: 21 DEC 1998 | DOI: 10.1002/(SICI)1097-0258(19980815/30)17:15/16<1753::AID-SIM977>3.0.CO;2-X

    3. A comparison of various estimators of a treatment difference for a multi-centre clinical trial (pages 1767–1777)

      B. Jones, D. Teather, J. Wang and J. A. Lewis

      Article first published online: 21 DEC 1998 | DOI: 10.1002/(SICI)1097-0258(19980815/30)17:15/16<1767::AID-SIM978>3.0.CO;2-H

    4. Multi-centre trial analysis revisited (pages 1779–1797)

      A. Lawrence Gould

      Article first published online: 21 DEC 1998 | DOI: 10.1002/(SICI)1097-0258(19980815/30)17:15/16<1779::AID-SIM979>3.0.CO;2-7

  5. Discussions

    1. Top of page
    2. Preface
    3. Research Articles
    4. Discussions
    5. Research Articles
    6. Discussions
    7. Research Articles
    8. Discussions
    9. Research Articles
    10. Discussions
    11. Research Articles
    12. Discussions
    13. Research Articles
    1. Discussion (pages 1799–1800)

      Professor Peter R. Freeman

      Article first published online: 21 DEC 1998 | DOI: 10.1002/(SICI)1097-0258(19980815/30)17:15/16<1799::AID-SIM980>3.0.CO;2-V

  6. Research Articles

    1. Top of page
    2. Preface
    3. Research Articles
    4. Discussions
    5. Research Articles
    6. Discussions
    7. Research Articles
    8. Discussions
    9. Research Articles
    10. Discussions
    11. Research Articles
    12. Discussions
    13. Research Articles
    1. The management of interim analyses in drug development (pages 1801–1809)

      Karen M. Facey and John A. Lewis

      Article first published online: 21 DEC 1998 | DOI: 10.1002/(SICI)1097-0258(19980815/30)17:15/16<1801::AID-SIM981>3.0.CO;2-L

  7. Discussions

    1. Top of page
    2. Preface
    3. Research Articles
    4. Discussions
    5. Research Articles
    6. Discussions
    7. Research Articles
    8. Discussions
    9. Research Articles
    10. Discussions
    11. Research Articles
    12. Discussions
    13. Research Articles
    1. Discussion (pages 1811–1812)

      Professor John Whitehead

      Article first published online: 21 DEC 1998 | DOI: 10.1002/(SICI)1097-0258(19980815/30)17:15/16<1811::AID-SIM982>3.0.CO;2-H

  8. Research Articles

    1. Top of page
    2. Preface
    3. Research Articles
    4. Discussions
    5. Research Articles
    6. Discussions
    7. Research Articles
    8. Discussions
    9. Research Articles
    10. Discussions
    11. Research Articles
    12. Discussions
    13. Research Articles
    1. Providing evidence of efficacy for a new drug (pages 1813–1823)

      Stephen Ruberg and Victoria Cairns

      Article first published online: 21 DEC 1998 | DOI: 10.1002/(SICI)1097-0258(19980815/30)17:15/16<1813::AID-SIM983>3.0.CO;2-8

  9. Discussions

    1. Top of page
    2. Preface
    3. Research Articles
    4. Discussions
    5. Research Articles
    6. Discussions
    7. Research Articles
    8. Discussions
    9. Research Articles
    10. Discussions
    11. Research Articles
    12. Discussions
    13. Research Articles
    1. Discussion (pages 1825–1827)

      A. Lawrence Gould

      Article first published online: 21 DEC 1998 | DOI: 10.1002/(SICI)1097-0258(19980815/30)17:15/16<1825::AID-SIM984>3.0.CO;2-Z

  10. Research Articles

    1. Top of page
    2. Preface
    3. Research Articles
    4. Discussions
    5. Research Articles
    6. Discussions
    7. Research Articles
    8. Discussions
    9. Research Articles
    10. Discussions
    11. Research Articles
    12. Discussions
    13. Research Articles
    1. A framework establishing clear decision criteria for the assessment of drug efficacy (pages 1829–1838)

      William J. Huster and Gregory G. Enas

      Article first published online: 21 DEC 1998 | DOI: 10.1002/(SICI)1097-0258(19980815/30)17:15/16<1829::AID-SIM985>3.0.CO;2-K

    2. Statistical issues in pharmacoepidemiological case-control studies (pages 1839–1850)

      Deborah Ashby, Rosalind L. Smyth and Philip J. Brown

      Article first published online: 21 DEC 1998 | DOI: 10.1002/(SICI)1097-0258(19980815/30)17:15/16<1839::AID-SIM986>3.0.CO;2-G

    3. Biostatistical considerations in pharmacovigilance and pharmacoepidemiology: linking quantitative risk assessment in pre-market licensure application safety data, post-market alert reports and formal epidemiological studies (pages 1851–1858)

      Robert T. O'Neill

      Article first published online: 21 DEC 1998 | DOI: 10.1002/(SICI)1097-0258(19980815/30)17:15/16<1851::AID-SIM987>3.0.CO;2-Z

  11. Discussions

    1. Top of page
    2. Preface
    3. Research Articles
    4. Discussions
    5. Research Articles
    6. Discussions
    7. Research Articles
    8. Discussions
    9. Research Articles
    10. Discussions
    11. Research Articles
    12. Discussions
    13. Research Articles
    1. Discussion (pages 1859–1862)

      Professor Stephen J. W. Evans

      Article first published online: 21 DEC 1998 | DOI: 10.1002/(SICI)1097-0258(19980815/30)17:15/16<1859::AID-SIM988>3.0.CO;2-8

  12. Research Articles

    1. Top of page
    2. Preface
    3. Research Articles
    4. Discussions
    5. Research Articles
    6. Discussions
    7. Research Articles
    8. Discussions
    9. Research Articles
    10. Discussions
    11. Research Articles
    12. Discussions
    13. Research Articles
    1. Issues for covariance analysis of dichotomous and ordered categorical data from randomized clinical trials and non-parametric strategies for addressing them (pages 1863–1892)

      Gary G. Koch, Catherine M. Tangen, Jin-Whan Jung and Ingrid A. Amara

      Article first published online: 21 DEC 1998 | DOI: 10.1002/(SICI)1097-0258(19980815/30)17:15/16<1863::AID-SIM989>3.0.CO;2-M

SEARCH

SEARCH BY CITATION