Multiple imputation of missing blood pressure covariates in survival analysis
Article first published online: 12 MAR 1999
Copyright © 1999 John Wiley & Sons, Ltd.
Statistics in Medicine
Volume 18, Issue 6, pages 681–694, 30 March 1999
How to Cite
van Buuren, S., Boshuizen, H. C. and Knook, D. L. (1999), Multiple imputation of missing blood pressure covariates in survival analysis. Statist. Med., 18: 681–694. doi: 10.1002/(SICI)1097-0258(19990330)18:6<681::AID-SIM71>3.0.CO;2-R
- Issue published online: 12 MAR 1999
- Article first published online: 12 MAR 1999
- Manuscript Accepted: JUN 1998
- Manuscript Received: NOV 1996
This paper studies a non-response problem in survival analysis where the occurrence of missing data in the risk factor is related to mortality. In a study to determine the influence of blood pressure on survival in the very old (85+ years), blood pressure measurements are missing in about 12·5 per cent of the sample. The available data suggest that the process that created the missing data depends jointly on survival and the unknown blood pressure, thereby distorting the relation of interest. Multiple imputation is used to impute missing blood pressure and then analyse the data under a variety of non-response models. One special modelling problem is treated in detail; the construction of a predictive model for drawing imputations if the number of variables is large. Risk estimates for these data appear robust to even large departures from the simplest non-response model, and are similar to those derived under deletion of the incomplete records. Copyright © 1999 John Wiley & Sons, Ltd.