Role of fine-needle aspiration biopsy in breast lesions: Analysis of a series of 4,110 cases
Article first published online: 7 DEC 1998
Copyright © 1998 Wiley-Liss, Inc.
Volume 18, Issue 6, pages 462–467, June 1998
How to Cite
Arisio, R., Cuccorese, C., Accinelli, G., Mano, M. P., Bordon, R. and Fessia, L. (1998), Role of fine-needle aspiration biopsy in breast lesions: Analysis of a series of 4,110 cases. Diagn. Cytopathol., 18: 462–467. doi: 10.1002/(SICI)1097-0339(199806)18:6<462::AID-DC16>3.0.CO;2-F
- Issue published online: 7 DEC 1998
- Article first published online: 7 DEC 1998
- Manuscript Accepted: 22 JUN 1997
- Manuscript Received: 23 FEB 1995
- fine-needle aspiration biopsy;
- breast neoplasms;
- cell block;
- breast cancer detection costs
From January of 1990 to December of 1992, 6,954 consecutive cytologic breast fine-needle aspiration biopsies (FNAB) were performed at the Laboratory of Pathology of Sant'Anna Hospital in Turin. Of these cases 62% were solid nodes, 35% were cystic nodes, and 2.7% were nonpalpable breast lesions (stereotaxic or ultrasound guided FNAB). We verified 4,110 cases: 913 cases underwent surgery and 3,197 were evaluated clinically, and/or cytologically, and/or with mammography at least 1 yr after the first diagnosis, or checked with the database of the Tumor Registry of Turin. In our series the FNAB sensitivity was 94.6%, specificity was 99.9%, accuracy was 98.8%, inadequate samples were 6.4%, false-negative rate was 1.4%, and false-positive rate was 0.3%. Our results indicate that the use of cell block improves sensitivity (from 85.2 to 94.6%) and strongly reduces false-negative results (from 3.9 to 1.4%).
We conclude that FNAB is a discriminant procedure to the surgical biopsy in cases with clinical, ultrasound, or mammographic low or intermediate suspect, contributing to allow a high malignant/benign surgical biopsy rate and to reduce the need for frozen section diagnosis and medical costs. Diagn. Cytopathol. 1998;18:462–467. © 1998 Wiley-Liss, Inc.