Reduced oxidative muscle metabolism in chronic fatigue syndrome
Article first published online: 7 DEC 1998
Copyright © 1996 John Wiley & Sons, Inc.
Muscle & Nerve
Volume 19, Issue 5, pages 621–625, May 1996
How to Cite
McCully, K. K., Natelson, B. H., Iotti, S., Sisto, S. and Leigh, J. S. (1996), Reduced oxidative muscle metabolism in chronic fatigue syndrome. Muscle Nerve, 19: 621–625. doi: 10.1002/(SICI)1097-4598(199605)19:5<621::AID-MUS10>3.0.CO;2-Q
- Issue published online: 7 DEC 1998
- Article first published online: 7 DEC 1998
- Manuscript Accepted: 6 JAN 1996
- NIH. Grant Numbers: AI-32247, RR02305
- 31P MRS;
- muscle injury;
- calf muscles
The purpose of this study was to determine if chronic fatigue syndrome (CSF) is characterized by abnormalities in oxidative muscle metabolism. Patients with CFS according to Centers for Disease Control (CDC) criteria (n = 22) were compared to normal sedentary subjects (n = 15). CFS patients were also tested before and 2 days after a maximal treadmill test. Muscle oxidative capacity was measured as the maximal rate of postexercise phosphocreatine (PCr) resynthesis using the ADP model (Vmax) in the calf muscles using 31P magnetic resonance spectroscopy. Vmax was significantly reduced in CFS patients (39.6 ± 2.8 mmol/L/min, mean ± SE) compared to controls (53.8 ± 2.8 mmol/L/min). Two days postexercise there was no change in resting inorganic phosphate (Pi)/PCr or Vmax in the CFS patients (n = 14). In conclusion, oxidative metabolism is reduced in CFS patients compared to sedentary controls. In addition, a single bout of strenuous exercise did not cause a further reduction in oxidative metabolism, or alter resting Pi/PCr ratios. © 1996 John Wiley & Sons, Inc.