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Short Report
Effects of dantrolene sodium on fibrillation potentials in denervated rat muscles
Article first published online: 12 DEC 1998
DOI: 10.1002/(SICI)1097-4598(199812)21:12<1797::AID-MUS28>3.0.CO;2-5
Copyright © 1998 John Wiley & Sons, Inc.
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Additional Information
How to Cite
Izumi, S.-I., Tsubahara, A., Chino, N. and Mineo, K. (1998), Effects of dantrolene sodium on fibrillation potentials in denervated rat muscles. Muscle Nerve, 21: 1797–1799. doi: 10.1002/(SICI)1097-4598(199812)21:12<1797::AID-MUS28>3.0.CO;2-5
Publication History
- Issue published online: 12 DEC 1998
- Article first published online: 12 DEC 1998
- Manuscript Accepted: 29 MAY 1998
- Abstract
- References
- Cited By
Keywords:
- fibrillation potential;
- denervation;
- calcium ion;
- dantrolene sodium;
- electromyography
Abstract
To examine whether a decrease in cytosolic Ca2+ affects fibrillation potentials, we studied effects of dantolene on these potentials in denervated rat muscle. Administered intraperitoneally, dantrolene sodium (12–22 mg/kg) abolished fibrillation potentials and subthreshold oscillating potentials over 2.5–6 h without affecting excitability of the muscle to electrical stimulation. Fibrillation potentials reappeared 36–96 h after administration of dantrolene. We suggest that cytosolic Ca2+ has a specific role in generating fibrillations. © 1998 John Wiley & Sons, Inc. Muscle Nerve 21: 1797–1799, 1998