Antibodies to the chlamydial 60 kilodalton heat shock protein in women with tubal factor infertility
Article first published online: 11 DEC 1998
Copyright © 1998 Wiley-Liss, Inc.
Infectious Diseases in Obstetrics and Gynecology
Volume 6, Issue 4, pages 163–167, 1998
How to Cite
Ault, K.A., Statland, B.D., King, M.M. S., Dozier, D.I.L., Joachims, M.L. and Gunter, J. (1998), Antibodies to the chlamydial 60 kilodalton heat shock protein in women with tubal factor infertility. Infect. Dis. Obstet. Gynecol., 6: 163–167. doi: 10.1002/(SICI)1098-0997(1998)6:4<163::AID-IDOG5>3.0.CO;2-6
- Issue published online: 11 DEC 1998
- Article first published online: 11 DEC 1998
- Manuscript Accepted: 20 AUG 1998
- Manuscript Received: 1 JUN 1998
- 1995 American College of Obstetricians and Gynecologists/Curatek Pharmaceuticals Research Award to Dr. Ault
- Cited By
- heat shock proteins
Fallopian tube damage and subsequent infertility are common sequelae of upper genital tract infection with Chlamydia trachomatis. This fallopian tube damage is thought to be immune mediated. The 60 kilodalton chlamydial heat shock protein (hsp) may be the key antigen associated with this pathogenic response. Our objective was to study the relationship between antibody response to 60 kilodalton chlamydial hsp and tubal factor infertility (TFI).
Subjects and Methods
Twenty-three women with TFI and 33 women with male factor infertility (controls) were studied. Tubal factor infertility was defined as infertility for one year with hydrosalpinx or distal tubal occlusion. Patients' sera were tested for antibodies to the chlamydial hsp using an enzyme-linked immunosorbent assay (ELISA). A stepwise logistic regression was performed by each patient's age, race/ethnicity, self-reported history of chlamydia infection, gonorrhea, or pelvic inflammatory disease (PID), history of ectopic pregnancy, and antibodies to the chlamydial hsp.
Eighteen of the 23 women with TFI had a positive result on the hsp ELISA (78.6%) versus 23.4% of controls. Risk factors for TFI were a history of PID (P = 0.022), “nonwhite” race (P = 0.004), history of ectopic pregnancy (P = 0.027), and antibodies to the 60 kilodalton chlamydial hsp (P < 0.001).
Antibodies to 60 kilodalton chlamydial hsp are strongly associated with TFI. Infect. Dis. Obstet. Gynecol. 6:163–167, 1998. © 1998 Wiley-Liss, Inc.