Chromosome arm 6q loss is the most common recurrent autosomal alteration detected in primary pediatric ependymoma
Article first published online: 8 FEB 1999
Copyright © 1999 Wiley-Liss, Inc.
Genes, Chromosomes and Cancer
Volume 24, Issue 3, pages 230–237, March 1999
How to Cite
Reardon, D. A., Entrekin, R. E., Sublett, J., Ragsdale, S., Li, H., Boyett, J., Kepner, J. L. and Look, A. T. (1999), Chromosome arm 6q loss is the most common recurrent autosomal alteration detected in primary pediatric ependymoma. Genes Chromosom. Cancer, 24: 230–237. doi: 10.1002/(SICI)1098-2264(199903)24:3<230::AID-GCC8>3.0.CO;2-C
- Issue published online: 8 FEB 1999
- Article first published online: 8 FEB 1999
- Manuscript Accepted: 9 SEP 1998
- Manuscript Received: 16 JUL 1998
- National Cancer Institute. Grant Numbers: CA71907, CA 29139, CA 21765
- American Lebanese Associated Charities (ALSAC)
We analyzed 23 samples of primary pediatric ependymoma for significant gains or losses of genomic DNA, using comparative genomic hybridization (CGH) and a rigorous statistical approach. Nine of the tumors in this series (39%) appeared normal by CGH. The remainder had a limited number of regions of genomic imbalance, most often involving losses of chromosome arms 6q and 22q and the X chromosome, or gains of either 1q or 9. Recurrent and exclusive losses of 6q or 22q suggest that these regions harbor tumor suppressor genes that may contribute independently to the pathogenesis of childhood ependymoma. Genes Chromosomes Cancer 24:230–237, 1999. © 1999 Wiley-Liss, Inc.