Genetic Epidemiology

Copyright © 2012 Wiley Periodicals Inc.

Cover image for Genetic Epidemiology

1997

Volume 14, Issue 6

Pages 549–1142

Issue edited by: Lynn R. Goldin, Joan E. Bailey-Wilson, Ingrid B. Borecki, Catherine T. Falk, Alisa M. Goldstein, Brian K. Suarez, Jean W. MacCluer

  1. Problem 1: Analysis of Linkage Data for Bipolar Illness

    1. Top of page
    2. Problem 1: Analysis of Linkage Data for Bipolar Illness
    3. Problem 2A: Analysis of Family Data for a Common Oligogenic Disease (Nuclear Families)
    4. Problem 2B: Analysis of Family Data for A Common Oligogenic Disease (Extended Pedigrees)
    5. Methodological and Theoretical Contributions
    1. Genetic analysis of bipolar disorder: Summary of GAW10 (pages 549–561)

      John Rice

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<549::AID-GEPI1>3.0.CO;2-V

    2. Description of the Genetic Analysis Workshop 10 bipolar disorder linkage data sets (pages 563–568)

      L.R. Goldin, E.S. Gershon, W.H. Berrettini, O.C. Stine, R. DePaulo, F. McMahon, D. Meyers, M. Nothen, P. Propping, S. Cichon, R. Fimmers, M. Baur, M. Albus, E. Franzek, R. Kreiner, W. Maier, M. Rietschel, M. Baron, J. Knowles, C. Gilliam, J. Endicott, H. Gurling, D. Curtis, C. Smyth and J. Kelsoe

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<563::AID-GEPI2>3.0.CO;2-0

    3. Bipolar disorder and chromosome 18: An analysis of multiple data sets (pages 569–574)

      Judith A. Badner and Lynn R. Goldin

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<569::AID-GEPI3>3.0.CO;2-V

    4. Investigation of the candidate genes ACTHR and Golf for bipolar illness by the transmission/disequilibrium test (pages 575–580)

      Heike Bickeböller, Maria Kistler and Michael Scholz

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<575::AID-GEPI4>3.0.CO;2-Z

    5. A new test statistic for linkage applied to bipolar disorder and marker D18S41 (pages 581–586)

      M.A. Cleves, D.V. Dawson, R.C. Elston and A.H. Schnell

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<581::AID-GEPI5>3.0.CO;2-2

    6. Disease classification and transmission effects on linkage analyses in the NIMH1 bipolar disorder pedigrees (pages 587–592)

      J.S. Collins and R.C.P. Go

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<587::AID-GEPI6>3.0.CO;2-X

    7. Confidence intervals for relative risk estimates from affected-sib-pair data (pages 593–598)

      Heather J. Cordell and Jane M. Olson

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<593::AID-GEPI7>3.0.CO;2-0

    8. Do multiple data sets provide support for a bipolar illness susceptibility locus on chromosome 18? (pages 599–604)

      Mark Daly, Andrew Kirby and Leonid Kruglyak

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<599::AID-GEPI8>3.0.CO;2-V

    9. Analysis of bipolar disorder using affected relatives (pages 605–610)

      Sean Davis, Eric Sobel, Marin Marinov and Daniel E. Weeks

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<605::AID-GEPI9>3.0.CO;2-Y

    10. Parental sex effects in bipolar affective disorder pedigrees (pages 611–616)

      J.A. Donald, J.A. Salmon, L.J. Adams, T. Littlejohn, A. Maher, P.B. Mitchell and P.R. Schofield

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<611::AID-GEPI10>3.0.CO;2-T

    11. A meta-analysis of chromosome 18 linkage data for bipolar illness (pages 617–622)

      David A. Dorr, John P. Rice, Chris Armstrong, Theodore Reich and Mary Blehar

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<617::AID-GEPI11>3.0.CO;2-T

    12. Exploring linkage of chromosome 18 markers and bipolar disease (pages 623–627)

      Martina Durner and Paula Abreu

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<623::AID-GEPI12>3.0.CO;2-S

    13. Association of posterior p-values of S.A.G.E. SIBPAL proportion-IBD and Haseman-Elston statistics for ACTHR112 (pages 629–634)

      Derek Gordon, Stephen J. Finch, Adam L. Jacobs, Nancy R. Mendell, Richard M. Single and Thomas G. Marr

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<629::AID-GEPI13>3.0.CO;2-S

    14. Incorporation of covariates into genome scanning using sib-pair analysis in bipolar affective disorder (pages 635–640)

      Celia M.T. Greenwood and Shelley B. Bull

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<635::AID-GEPI14>3.0.CO;2-R

    15. Affected-sib-pair analyses of bipolar disorder using data on chromosome 18 (pages 641–646)

      Fatemeh Haghighi, Wentian Li and Cathy S.J. Fann

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<641::AID-GEPI15>3.0.CO;2-Q

    16. Bipolar disorder: Dominant or recessive on chromosome 5? (pages 647–651)

      Jeanne P. Homer, Pamela L. Flodman and M. Anne Spence

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<647::AID-GEPI16>3.0.CO;2-Q

    17. Linkage analysis of complex disorders with multiple phenotypic categories: Simulation studies and application to bipolar disorder data (pages 653–658)

      Douglas F. Levinson

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<653::AID-GEPI17>3.0.CO;2-P

    18. GENEHUNTER: Application to analysis of bipolar pedigrees and some extensions (pages 659–663)

      Hongzhe Li and Daniel J. Schaid

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<659::AID-GEPI18>3.0.CO;2-P

    19. Parental transmission and D18S37 allele sharing in bipolar affective disorder (pages 665–668)

      JingPing Lin and Sherri J. Bale

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<665::AID-GEPI19>3.0.CO;2-O

    20. Heterogeneity of marker allele frequencies hinders interpretation of linkage analysis: Illustration on chromosome 18 markers (pages 669–674)

      Patricia Margaritte-Jeannin, Marie-Claude Babron, Emmanuelle Génin, Sophie Eichenbaum-Voline and F. Clerget-Darpoux

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<669::AID-GEPI20>3.0.CO;2-N

    21. Modeling age of onset and residual familial correlations for the linkage analysis of bipolar disorder (pages 675–680)

      Audrey H. Schnell, P. Mahinda Karunaratne, John S. Witte, Deborah V. Dawson and Robert C. Elston

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<675::AID-GEPI21>3.0.CO;2-M

    22. A Monte Carlo permutation approach to choosing an affection status model for bipolar affective disorder (pages 681–686)

      Katy L. Simonsen, Norman L. Kaplan and Eden R. Martin

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<681::AID-GEPI22>3.0.CO;2-L

    23. Modeling the phenotype in parametric linkage analysis of bipolar disorder (pages 687–691)

      Gustavo Turecki, Guy Rouleau and Kenneth Morgan

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<687::AID-GEPI23>3.0.CO;2-L

    24. Probabilistic diagnosis in linkage analysis of bipolar disorder: Putting weights on the fringe (pages 693–698)

      Paul Van Eerdewegh, Susan L. Santangelo, Hang Lee, Nan M. Laird and Deborah Blacker

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<693::AID-GEPI24>3.0.CO;2-K

    25. Linkage disequilibrium between the dopamine transporter gene (DAT1) and bipolar disorder: Extending the transmission disequilibrium test (TDT) to examine genetic heterogeneity (pages 699–704)

      Irwin D. Waldman, Byron F. Robinson and Sarah A. Feigon

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<699::AID-GEPI25>3.0.CO;2-K

    26. Comparison of selected methods used to analyze bipolar disorder (pages 705–710)

      Diego F. Wyszynski, Jennifer P. Doetsch, Elizabeth W. Pugh and Joan E. Bailey-Wilson

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<705::AID-GEPI26>3.0.CO;2-T

    27. Model-free age-of-onset methods applied to the linkage of bipolar disorder (pages 711–716)

      Xiaofeng Zhu, Jane M. Olson, Audrey H. Schnell and Robert C. Elston

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<711::AID-GEPI27>3.0.CO;2-S

  2. Problem 2A: Analysis of Family Data for a Common Oligogenic Disease (Nuclear Families)

    1. Top of page
    2. Problem 1: Analysis of Linkage Data for Bipolar Illness
    3. Problem 2A: Analysis of Family Data for a Common Oligogenic Disease (Nuclear Families)
    4. Problem 2B: Analysis of Family Data for A Common Oligogenic Disease (Extended Pedigrees)
    5. Methodological and Theoretical Contributions
    1. Genetic analysis of simulated oligogenic traits in nuclear and extended pedigrees: Summary of GAW10 contributions (pages 719–735)

      Ellen M. Wijsman and Christopher I. Amos

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<719::AID-GEPI28>3.0.CO;2-S

    2. GAW10: Simulated family data for a common oligogenic disease with quantitative risk factors (pages 737–742)

      Jean W. MacCluer, John Blangero, Thomas D. Dyer and Marcy C. Speer

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<737::AID-GEPI29>3.0.CO;2-Q

    3. Comparison of model-free linkage mapping strategies for the study of a complex trait (pages 743–748)

      C.I. Amos, J. Krushkal, T.J. Thiel, A. Young, D.K. Zhu, E. Boerwinkle and M. de Andrade

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<743::AID-GEPI30>3.0.CO;2-O

    4. Impact of adjustments for intermediate phenotypes on the power to detect linkage (pages 749–754)

      Donna K. Arnett, James S. Pankow, Larry D. Atwood and Thomas A. Sellers

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<749::AID-GEPI31>3.0.CO;2-O

    5. Prior segregation analysis and the power to detect linkage (pages 755–760)

      Larry D. Atwood and Susan H. Slifer

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<755::AID-GEPI32>3.0.CO;2-N

    6. A multivariate approach to affected-sib-pair analysis using highly dense molecular maps (pages 761–766)

      Julia N. Bailey, Christina G.S. Palmer, J. Arthur Woodward and Susan L. Smalley

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<761::AID-GEPI33>3.0.CO;2-M

    7. The effect of selective sampling on mapping quantitative trait loci (pages 767–772)

      Nicola J. Camp and Aruna Bansal

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<767::AID-GEPI34>3.0.CO;2-M

    8. Assessing linkage on chromosome 5 using components of variance approach: Univariate versus multivariate (pages 773–778)

      M. de Andrade, T.J. Thiel, LiPing Yu and C.I. Amos

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<773::AID-GEPI35>3.0.CO;2-L

    9. False discoveries in genome scanning (pages 779–784)

      Eugene I. Drigalenko and Robert C. Elston

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<779::AID-GEPI36>3.0.CO;2-L

    10. Improvement of the power to detect complex disease genes by regional inference procedures (pages 785–789)

      Lynn R. Goldin and Gary A. Chase

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<785::AID-GEPI37>3.0.CO;2-K

    11. Genome screening using extremely discordant and extremely concordant sib pairs (pages 791–796)

      Chi Gu, A.A. Todorov and D.C. Rao

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<791::AID-GEPI38>3.0.CO;2-J

    12. The power of iterated generalized least squares (GLS) method to detect direct relationships in the analysis of correlated quantitative traits (pages 797–801)

      Qimei He, Barbara B. Nemesure and Nancy R. Mendell

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<797::AID-GEPI39>3.0.CO;2-J

    13. A population based family study of a common oligogenic disease — part I: Association/aggregation analysis (pages 803–807)

      Sarah Holte, Filemon Quiaoit, Li Hsu, Ori Davidov and Lue Ping Zhao

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<803::AID-GEPI40>3.0.CO;2-R

    14. Detection of major genes underlying several quantitative traits associated with a common disease using different ascertainment schemes (pages 809–814)

      Sudha Iyengar, Francesc Calafell and Kenneth K. Kidd

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<809::AID-GEPI41>3.0.CO;2-R

    15. A comprehensive analysis of complex traits in problem 2A (pages 815–820)

      S.H. Juo, T.H. Beaty, D.L. Duffy, N.E. Maestri, V.L. Prenger, J. Zeiger, H.H. Lei and J. Coresh

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<815::AID-GEPI42>3.0.CO;2-Q

    16. Linked markers and age at diagnosis (pages 821–825)

      Terri M. King and Ying Wan

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<821::AID-GEPI43>3.0.CO;2-P

    17. Sib-pair linkage analyses of nuclear family data: Quantitative versus dichotomous disease classification (pages 827–832)

      Jeannette F. Korczak and Alisa M. Goldstein

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<827::AID-GEPI44>3.0.CO;2-P

    18. The “possible triangle” test for extreme discordant sib pairs (pages 833–838)

      Rita Kruse, Susanne A. Seuchter, Max P. Baur and Michael Knapp

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<833::AID-GEPI45>3.0.CO;2-O

    19. Multilocus quantitative trait analysis using the multipoint identity-by-descent method (pages 839–844)

      Cathryn M. Lewis and Edward N. Kort

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<839::AID-GEPI46>3.0.CO;2-O

    20. Multipoint analysis of quantitative traits (pages 845–850)

      A.J. Marlow, S. John and J. Worthington

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<845::AID-GEPI47>3.0.CO;2-N

    21. Genomic scanning and the transmission/disequilibrium test: Analysis of error rates (pages 854–856)

      Michael B. Miller

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<854::AID-GEPI48>3.0.CO;2-M

    22. Logistic transmission modeling for the simulated data of GAW10 problem 2 (pages 857–860)

      Barbara R. Neas, Kathy L. Moser and John B. Harley

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<857::AID-GEPI49>3.0.CO;2-M

    23. Analysis of complex oligogenic disease (pages 861–866)

      Jeffrey R. O'Connell, Sean Davis and Daniel E. Weeks

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<861::AID-GEPI50>3.0.CO;2-K

    24. Comparison of sib-pair and variance-components methods for genomic screening (pages 867–872)

      Elizabeth W. Pugh, Cashell E. Jaquish, Alexa J.M. Sorant, Jennifer P. Doetsch, Joan E. Bailey-Wilson and Alexander F. Wilson

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<867::AID-GEPI51>3.0.CO;2-K

    25. The utility of deviant sib pairs in the detection of linkage (pages 873–878)

      Daniel R. Rochberg, Nan Rochberg, Carol L. Hampe and Brian K. Suarez

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<873::AID-GEPI52>3.0.CO;2-J

    26. Effectiveness of extreme discordant sib pairs to detect oligogenic disease loci (pages 879–884)

      John J. Rogus, David P. Harrington, Eric Jorgenson and Xiping Xu

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<879::AID-GEPI53>3.0.CO;2-J

    27. Sequential sib-pair and association studies to detect genes in quantitative traits (pages 885–890)

      Amanda Savage, Fengzhu Sun, Dana C. Crawford, Allison E. Ashley, Quanhe Yang and Stephanie L. Sherman

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<885::AID-GEPI54>3.0.CO;2-I

    28. False positive rates in a genomic screen for complex quantitative traits (pages 891–896)

      William K. Scott, Marcy C. Speer, Suzanne M. Leal, Linda M. Brzustowicz, Carol S. Haynes and Margaret A. Pericak-Vance

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<891::AID-GEPI55>3.0.CO;2-H

    29. The performance of MIM in comparison with MAPMAKER/SIBS to detect QTLs (pages 897–902)

      Yin Y. Shugart and David E. Goldgar

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<897::AID-GEPI56>3.0.CO;2-H

    30. A Bayesian approach to multipoint mapping in nuclear families (pages 903–908)

      Duncan C. Thomas, Sylvia Richardson, James Gauderman and Janne Pitkäniemi

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<903::AID-GEPI57>3.0.CO;2-Q

    31. Probabilities of identity-by-descent patterns in sibships when the parents are not genotyped (pages 909–913)

      A.A. Todorov, K.D. Siegmund, C. Gu, I.B. Borecki and R.C. Elston

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<909::AID-GEPI58>3.0.CO;2-Q

    32. Haplotype sharing analysis in affected individuals from nuclear families with at least one affected offspring (pages 915–919)

      Martin A. Van der Meulen and Gerard J. te Meerman

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<915::AID-GEPI59>3.0.CO;2-P

    33. A multivariate model for the analysis of sibship covariance structure using marker information and multiple quantitative traits (pages 921–926)

      George P. Vogler, Weihong Tang, Tracy L. Nelson, Scott M. Hofer, Julia D. Grant, Lisa M. Tarantino and Jose R. Fernandez

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<921::AID-GEPI60>3.0.CO;2-N

    34. Empirical evaluation of genome scans for linkage of a quantitative trait associated with a complex disorder (pages 927–932)

      Jianfeng Xu, Carolien Panhuysen, Eugene Taylor, Denise Wiesch and Deborah Meyers

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<927::AID-GEPI61>3.0.CO;2-N

    35. Factors influencing the identification of major genes in a complex disease genome scan (pages 933–938)

      Huiying Yang, Yaping Wang, Darlene R. Goldstein, Zhiming Li, Hita Vora and Rita M. Cantor

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<933::AID-GEPI62>3.0.CO;2-M

    36. The method of sib-pair linkage analysis in context of case-control design (pages 939–944)

      Quanhe Yang, Michael Atkinson, Fengzhu Sun, Stephanie Sherman and Muin J. Khoury

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<939::AID-GEPI63>3.0.CO;2-M

    37. A population-based family study (II): Segregation analysis (pages 945–949)

      L.P. Zhao, F. Quiaoit, L. Hsu, O. Davidov and S. Holte

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<945::AID-GEPI64>3.0.CO;2-L

  3. Problem 2B: Analysis of Family Data for A Common Oligogenic Disease (Extended Pedigrees)

    1. Top of page
    2. Problem 1: Analysis of Linkage Data for Bipolar Illness
    3. Problem 2A: Analysis of Family Data for a Common Oligogenic Disease (Nuclear Families)
    4. Problem 2B: Analysis of Family Data for A Common Oligogenic Disease (Extended Pedigrees)
    5. Methodological and Theoretical Contributions
    1. Bivariate quantitative trait linkage analysis: Pleiotropy versus co-incident linkages (pages 953–958)

      Laura Almasy, Thomas D. Dyer and John Blangero

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<953::AID-GEPI65>3.0.CO;2-K

    2. Multipoint oligogenic linkage analysis of quantitative traits (pages 959–964)

      John Blangero and Laura Almasy

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<959::AID-GEPI66>3.0.CO;2-K

    3. Comparison of evidence for linkage from different analytic methods (pages 965–970)

      Shelley B. Bull, Dushanthi Pinnaduwage, Janey Shin, Fang Xie and David Tritchler

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<965::AID-GEPI67>3.0.CO;2-J

    4. WPC test based on randomization for analyzing quantitative traits on simulated pedigrees (pages 971–974)

      Daniel Commenges and Marie Beurton-Aimar

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<971::AID-GEPI68>3.0.CO;2-I

    5. Exploiting pleiotropy to map genes for oligogenic phenotypes using extended pedigree data (pages 975–980)

      Anthony G. Comuzzie, Michael C. Mahaney, Laura Almasy, Thomas D. Dyer and John Blangero

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<975::AID-GEPI69>3.0.CO;2-I

    6. Detecting linkage for a complex disease using simulated extended pedigrees (pages 981–986)

      Anita L. DeStefano, L. Adrienne Cupples, Richard H. Myers and Lindsay A. Farrer

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<981::AID-GEPI70>3.0.CO;2-G

    7. A variance component approach to dichotomous trait linkage analysis using a threshold model (pages 987–992)

      Ravindranath Duggirala, Jeff T. Williams, Sarah Williams-Blangero and John Blangero

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<987::AID-GEPI71>3.0.CO;2-G

    8. Joint segregation and linkage analysis of a quantitative trait compared to separate analyses (pages 993–998)

      W. James Gauderman, Cheryl L. Faucett, John L. Morrison and Catherine L. Carpenter

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<993::AID-GEPI72>3.0.CO;2-F

    9. Segregation and linkage analysis of a quantitative versus a qualitative trait in large pedigrees (pages 999–1004)

      Jinko Graham, Nicola H. Chapman, Katrina A.B. Goddard, Ellen L. Goode, Ellen M. Wijsman and Gail P. Jarvik

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<999::AID-GEPI73>3.0.CO;2-F

    10. An extension of affected-pedigree-member analyses to triads of relatives (pages 1005–1010)

      Elena L. Grigorenko and Joseph T. Chang

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<1005::AID-GEPI74>3.0.CO;2-M

    11. MCMC segregation and linkage analysis (pages 1011–1016)

      S.C. Heath, G.L. Snow, E.A. Thompson, C. Tseng and E.M. Wijsman

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<1011::AID-GEPI75>3.0.CO;2-L

    12. Power of variance component linkage analysis to detect epistasis (pages 1017–1022)

      Braxton D. Mitchell, Soumitra Ghosh, Jennifer L. Schneider, Gunther Birznieks and John Blangero

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<1017::AID-GEPI76>3.0.CO;2-L

    13. Detection and replication of linkage to a complex human disease (pages 1023–1028)

      Steven O. Moldin

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<1023::AID-GEPI77>3.0.CO;2-K

    14. Affected-only multiplex pedigree analysis of GAW10 problem 2 (pages 1029–1034)

      Derek J. Nancarrow and Bryan J. Mowry

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<1029::AID-GEPI78>3.0.CO;2-K

    15. Testing the utility of mod scores and sib-pair analysis to detect presence of disease susceptibility loci (pages 1035–1040)

      Rosalind J. Neuman and Hong Xian

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<1035::AID-GEPI79>3.0.CO;2-J

    16. Identifying genetic markers to assess the presence of gene-environment interactions (pages 1041–1046)

      F. Seillier-Moiseiwitsch, H. Pinheiro, H. Li and B. Newman

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<1041::AID-GEPI80>3.0.CO;2-H

    17. The role of smoothing techniques in the interpretation of results from genomic scans using sib-pair data (pages 1047–1052)

      K.D. Siegmund, A.A. Todorov, D.C. Rao and I.B. Borecki

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<1047::AID-GEPI81>3.0.CO;2-H

    18. Effects of genotype-by-sex interaction on quantitative trait linkage analysis (pages 1053–1058)

      Bradford Towne, Roger M. Siervogel and John Blangero

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<1053::AID-GEPI82>3.0.CO;2-G

    19. Covariate effects on linkage and association using a general pair method (pages 1059–1064)

      Patrick J. Ward

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<1059::AID-GEPI83>3.0.CO;2-G

    20. Statistical properties of a variance components method for quantitative trait linkage analysis in nuclear families and extended pedigrees (pages 1065–1070)

      Jeff T. Williams, Ravindranath Duggirala and John Blangero

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<1065::AID-GEPI84>3.0.CO;2-F

  4. Methodological and Theoretical Contributions

    1. Top of page
    2. Problem 1: Analysis of Linkage Data for Bipolar Illness
    3. Problem 2A: Analysis of Family Data for a Common Oligogenic Disease (Nuclear Families)
    4. Problem 2B: Analysis of Family Data for A Common Oligogenic Disease (Extended Pedigrees)
    5. Methodological and Theoretical Contributions
    1. Empirical affected-sib-pair statistics: Two simulation strategies (pages 1073–1078)

      Christian Dina, Jean-Claude Buzzi, Florence Demenais and Maria Martinez

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<1073::AID-GEPI85>3.0.CO;2-E

    2. Caution in the interpretation of MLS (pages 1079–1083)

      Sophie Eichenbaum-Voline, Emmanuelle Génin, Marie-Claude Babron, Patricia Margaritte-Jeannin, Bernard Prum and Françoise Clerget-Darpoux

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<1079::AID-GEPI86>3.0.CO;2-E

    3. Detecting gene-environment interactions using a case-control design (pages 1085–1089)

      Alisa M. Goldstein, Roni T. Falk, Jeannette F. Korczak and Jay H. Lubin

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<1085::AID-GEPI87>3.0.CO;2-D

    4. A new statistical test for age-of-onset anticipation: Application to bipolar disorder (pages 1091–1096)

      Jian Huang and Veronica Vieland

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<1091::AID-GEPI88>3.0.CO;2-C

    5. Analysis of two-locus traits under heterogeneity for recessive versus dominant inheritance (pages 1097–1100)

      Suzanne M. Leal and Jurg Ott

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<1097::AID-GEPI89>3.0.CO;2-C

    6. Neural network analysis of complex traits (pages 1101–1106)

      Paul R. Lucek and Jurg Ott

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<1101::AID-GEPI90>3.0.CO;2-K

    7. Affected sib-pair tests for linkage: Type I errors with dependent sib-pairs (pages 1107–1111)

      Flavie Meunier, Anne Philippi, Maria Martinez and Florence Demenais

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<1107::AID-GEPI91>3.0.CO;2-K

    8. Genotype relative-risks and association tests for nuclear families with missing parental data (pages 1113–1118)

      Daniel J. Schaid and Hongzhe Li

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<1113::AID-GEPI92>3.0.CO;2-J

    9. Investigating the numerical effects of ascertainment bias in linkage analysis: Development of methods and preliminary results (pages 1119–1124)

      Susan L. Slager and Veronica J. Vieland

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<1119::AID-GEPI93>3.0.CO;2-J

    10. Genomic sharing surrounding alleles identical by descent: Effects of genetic drift and population growth (pages 1125–1130)

      Gerard J. te Meerman and Martin A. Van der Meulen

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<1125::AID-GEPI94>3.0.CO;2-I

    11. Deriving components of genetic variance for multilocus models (pages 1131–1136)

      Hemant K. Tiwari and Robert C. Elston

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<1131::AID-GEPI95>3.0.CO;2-H

    12. Genetic analysis with hierarchical models (pages 1137–1142)

      J.S. Witte

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1098-2272(1997)14:6<1137::AID-GEPI96>3.0.CO;2-H

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