Anaplastic large cell lymphoma: a clinicopathologic analysis
Article first published online: 20 MAR 2000
Copyright © 1999 John Wiley & Sons, Ltd.
Volume 17, Issue 4, pages 137–148, December 1999
How to Cite
Skinnider, B. F., Connors, J. M., Sutcliffe, S. B. and Gascoyne, R. D. (1999), Anaplastic large cell lymphoma: a clinicopathologic analysis. Hematol. Oncol., 17: 137–148. doi: 10.1002/(SICI)1099-1069(199912)17:4<137::AID-HON642>3.0.CO;2-V
- Issue published online: 20 MAR 2000
- Article first published online: 20 MAR 2000
- Manuscript Received: 1 SEP 1999
- chromosome 2;
- chromosome 5;
The clinicopathologic features of anaplastic large cell lymphoma (ALCL) are reviewed. ALCL is a heterogeneous group of tumours, and histologic examination alone is not adequate in providing useful prognostic information. However, using a combination of clinical, phenotypic, and genotypic features, several distinct clinicopathologic entities have been identified. A subset of ALCL as presently defined is characterized by a balanced translocation, t(2;5)(p23;q35), resulting in a novel fusion protein (NPM-ALK) that can be readily detected by immunohistochemical methods using antibodies against the ALK protein. Detection of ALK protein, along with other methods for demonstrating the t(2;5), has assisted in identifying a distinct biologic entity within the heterogeneous group of ALCL with significant prognostic implications. It is important to separate these from cases of ALK-negative ALCL, which have a poorer prognosis, and cases of primary cutaneous ALCL, which have an excellent prognosis. Copyright © 1999 John Wiley & Sons, Ltd.