Research Article

Efficient syntheses of multiply 2H- and 13C-labeled acrylic acid, glyceric acid, glycidic acid and glycerol

  1. János Pitlik,
  2. Craig A. Townsend*

Article first published online: 4 DEC 1998

DOI: 10.1002/(SICI)1099-1344(199712)39:12<999::AID-JLCR45>3.0.CO;2-Q

Issue

Journal of Labelled Compounds and Radiopharmaceuticals

Journal of Labelled Compounds and Radiopharmaceuticals

Volume 39, Issue 12, pages 999–1009, December 1997

Additional Information

How to Cite

Pitlik, J. and Townsend, C. A. (1997), Efficient syntheses of multiply 2H- and 13C-labeled acrylic acid, glyceric acid, glycidic acid and glycerol. Journal of Labelled Compounds and Radiopharmaceuticals, 39: 999–1009. doi: 10.1002/(SICI)1099-1344(199712)39:12<999::AID-JLCR45>3.0.CO;2-Q

Author Information

  1. Department of Chemistry, The Johns Hopkins University, Baltimore, MD 21218, USA

*Department of Chemistry, The Johns Hopkins University, Baltimore, MD 21218, USA

Publication History

  1. Issue published online: 4 DEC 1998
  2. Article first published online: 4 DEC 1998
  3. Manuscript Revised: 11 AUG 1997
  4. Manuscript Received: 4 JUN 1997

Funded by

  • National Institute of Health. Grant Numbers: RO1-AI14937, FO5 TW05111

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Keywords:

  • paired isotope (2H,13C) synthesis;
  • acrylic acid;
  • glyceric acid;
  • glycidic acid;
  • glycerol

Abstract

Syntheses of multiply 2H- and 13C-labeled C-3 carbohydrates have been carried out from commercially available [1,2-13C2]bromoacetic acid. The syntheses are illustrated for [1,2-13C2]acrylate, [2,3,3-2H3, 1,2-13C2]acrylate, [1,2-13C2]glycerate, [2,3,3-2H3, 1,2-13C2]glycerate, [1,2-13C2]glycidate and [1,1-2H2, 1,2-13C2]glycerol. © 1997 John Wiley & Sons, Ltd.

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