Synthesis of 2H3-labelled misoprostol and its primary plasma metabolite

Authors

  • Ana Rodriguez,

    1. Department of Cell Biology, University of Medicine and Dentistry of New Jersey, SOM, Stratford, New Jersey 08084, USA
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  • Miguel Nomen,

    1. Department of Cell Biology, University of Medicine and Dentistry of New Jersey, SOM, Stratford, New Jersey 08084, USA
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  • Bernd W. Spur,

    Corresponding author
    1. Department of Cell Biology, University of Medicine and Dentistry of New Jersey, SOM, Stratford, New Jersey 08084, USA
    • Department of Cell Biology, University of Medicine and Dentistry, 2 Medical Center Drive, Stratford, New Jersey, NJ 08084, USA.
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  • Jean-Jacques Godfroid

    1. Laboratorie de Pharmacochimie Moléculaire, Universite Paris 7, Paris 75251, France
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Abstract

Misoprostol-d3 (15) and its major plasma metabolite misoprostol free acid-d3 (5) were synthesized starting from commercially available methyl-d3-magnesium iodide. Copyright © 1999 John Wiley & Sons, Ltd.

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