Research Article

A Study of Some Pharmacodynamic Actions of Certain Melaleuca Species Grown in Egypt

  1. E. A. Aboutabl1,*,
  2. G. Abdelhakim1,
  3. F. A. Moharram2

Article first published online: 4 DEC 1998

DOI: 10.1002/(SICI)1099-1573(199606)10:4<345::AID-PTR835>3.0.CO;2-E

Issue

Phytotherapy Research

Phytotherapy Research

Volume 10, Issue 4, pages 345–347, June 1996

Additional Information

How to Cite

Aboutabl, E. A., Abdelhakim, G. and Moharram, F. A. (1996), A Study of Some Pharmacodynamic Actions of Certain Melaleuca Species Grown in Egypt. Phytotherapy Research, 10: 345–347. doi: 10.1002/(SICI)1099-1573(199606)10:4<345::AID-PTR835>3.0.CO;2-E

Author Information

  1. 1

    Pharmacognosy and Pharmacology Departments, Faculties of Pharmacy, and Veterinary Medicine, Cairo University, Egypt

  2. 2

    Department of Chemistry of Natural and Microbial Products, National Research Center, Dokki, Cairo, Egypt

*Pharmacognosy and Pharmacology Departments, Faculties of Pharmacy, and Veterinary Medicine, Cairo University, Egypt

Publication History

  1. Issue published online: 4 DEC 1998
  2. Article first published online: 4 DEC 1998
  3. Manuscript Accepted: 12 JUN 1995

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

Get PDF (267K)

Keywords:

  • Melaleuca elliptica;
  • M. bracteata;
  • M. quinquenervia;
  • M. styphelioides;
  • LD50;
  • analgesic;
  • antipyretic;
  • antiinflammatory;
  • antimicrobial;
  • molluscicidal

Abstract

Some pharmacological actions of ethanol extracts of M. elliptica, M. bracteata, M. quinquenervia and M. styphelioides as well as the volatile oil of M. elliptica were experimentally investigated. The ethanol extracts of the plants were nontoxic (LD50 are 102.5, 260.0, 147.5 and 168.0 mg/kg b.wt, respectively). The extracts inhibited spontaneous contraction of smooth muscle of isolated rabbit intestine and rat uterus. They produced myocardial inhibition and decreased the motility of Taenia worms. Ethanol extracts of M. elliptica, M. bracteata, M. quinquenervia and M. styphelioides had no antipyretic, antiinflammatory or molluscicidal activities, whereas the ethanol extract of M. styhphelioides had an analgesic effect in mice. The volatile oil of M. elliptica inhibited the intestinal motility but stimulated the myocardial contractions of rabbits. It had analgesic, molluscicidal and antimicrobial activities, but lacked both antipyretic and antiinflammatory effects.

Get PDF (267K)