Inhibition of the passive diffusion of cholic acid by the Ilex paraguariensis St. Hil. saponins

Authors

  • Fernando Ferreira,

    Corresponding author
    1. Cátedra de Farmacognosia y Productos Naturales, Facultad de Química, General Flores 2124, CP 1157, Montevideo, Uruguay
    • Cátedra de Farmacognosia y Productos Naturales, Facultad de Química, General Flores 2124, CP 1157, Montevideo, Uruguay
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  • Alvaro Vázquez,

    1. Cátedra de Farmacognosia y Productos Naturales, Facultad de Química, General Flores 2124, CP 1157, Montevideo, Uruguay
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  • Carlos Güntner,

    1. Cátedra de Farmacognosia y Productos Naturales, Facultad de Química, General Flores 2124, CP 1157, Montevideo, Uruguay
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  • Patrick Moyna

    1. Cátedra de Farmacognosia y Productos Naturales, Facultad de Química, General Flores 2124, CP 1157, Montevideo, Uruguay
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Abstract

The Ilex paraguariensis St. Hil. (yerba mate) saponins effectively inhibit the passive diffusion of cholic acid through dialysis membranes. The formation of large macromolecular mixed micelles between cholic acid and yerba mate saponins could explain this effect. The observed inhibition of the passive diffusion of cholic acid used as a model of bile acids, could have an antihypercholesterolaemic effect in vivo due to an increased sterols excretion. © 1997 John Wiley & Sons, Ltd.

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