Effects of peppermint oil and caraway oil on gastroduodenal motility
Article first published online: 11 MAY 2000
Copyright © 2000 John Wiley & Sons, Ltd.
Volume 14, Issue 1, pages 20–23, February 2000
How to Cite
Micklefield, G. H., Greving, I. and May, B. (2000), Effects of peppermint oil and caraway oil on gastroduodenal motility. Phytother. Res., 14: 20–23. doi: 10.1002/(SICI)1099-1573(200002)14:1<20::AID-PTR542>3.0.CO;2-Z
- Issue published online: 11 MAY 2000
- Article first published online: 11 MAY 2000
- Manuscript Accepted: 9 MAR 1999
- Manuscript Received: 27 JAN 1999
- peppermint oil;
- caraway oil;
- gastroduodenal motility
The effect of enteric-coated (Enteroplant®) and non-enteric-coated preparations containing a peppermint–caraway oil combination with 90 mg peppermint oil and 50 mg caraway oil was studied on gastroduodenal motility with stationary manometry in six healthy volunteers. The results showed that: (1) both enteric-coated and non-enteric-coated preparations have effects on the migrating motor complex (MMC); (2) mainly a decrease in the number of contractions and contraction amplitudes is seen during the various phases of the MMC; (3) non-enteric-coated preparations have their effects mainly during the first MMC after administration; (4) enteric-coated preparations have their effects temporally delayed during the second MMC after administration. In conclusion, enteric-coated and non-enteric-coated peppermint–caraway oil combinations are safe preparations, acting locally to cause smooth muscle relaxation. Copyright © 2000 John Wiley & Sons, Ltd.