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Review
EBNA-1: a protein pivotal to latent infection by Epstein–Barr virus
Article first published online: 10 MAR 2000
DOI: 10.1002/(SICI)1099-1654(200003/04)10:2<83::AID-RMV262>3.0.CO;2-T
Copyright © 2000 John Wiley & Sons, Ltd.
1099-1654/asset/cover.gif?v=1&s=5c134e30087ac75193a3e23086b72a34fcfa922b "Reviews in Medical Virology")
Additional Information
How to Cite
Leight, E. R. and Sugden, B. (2000), EBNA-1: a protein pivotal to latent infection by Epstein–Barr virus. Reviews in Medical Virology, 10: 83–100. doi: 10.1002/(SICI)1099-1654(200003/04)10:2<83::AID-RMV262>3.0.CO;2-T
Publication History
- Issue published online: 10 MAR 2000
- Article first published online: 10 MAR 2000
- Manuscript Accepted: 22 AUG 1999
Funded by
- Public Health Service. Grant Numbers: CA-22443, CA-07175, T32-CA-09135, CA-70723
- Abstract
- References
- Cited By
Abstract
Epstein–Barr nuclear antigen 1, or EBNA-1, is required for the replication of the EBV genome as an extra‒chromosomal element and is a key transcriptional regulator of this virus's latent gene expression. In this review we will describe the salient features of EBNA-1 and oriP, the latent origin of EBV to which EBNA-1 binds site-specifically. EBNA-1's association with host cellular factors, its association with metaphase chromosomes, and its ability to link DNAs to which it binds will be discussed in relation to its roles in replication and transcriptional activation. Although the mechanisms by which EBNA-1 facilitates replication and transcription largely remain enigmatic, EBV's viral replicon has been exploited successfully for applications in gene therapy and in the design of eukaryotic vectors for use in cell culture. Copyright © 2000 John Wiley & Sons, Ltd.