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Acute exposure to a 60 Hz magnetic field increases DNA strand breaks in rat brain cells
Article first published online: 6 DEC 1998
DOI: 10.1002/(SICI)1521-186X(1997)18:2<156::AID-BEM8>3.0.CO;2-1
Copyright © 1997 Wiley-Liss, Inc.
1521-186X/asset/cover.gif?v=1&s=3993f629feef258468e5fe13a495ef5dc0aa6bfc "Bioelectromagnetics")
Additional Information
How to Cite
Lai, H. and Singh, N. P. (1997), Acute exposure to a 60 Hz magnetic field increases DNA strand breaks in rat brain cells. Bioelectromagnetics, 18: 156–165. doi: 10.1002/(SICI)1521-186X(1997)18:2<156::AID-BEM8>3.0.CO;2-1
Publication History
- Issue published online: 6 DEC 1998
- Article first published online: 6 DEC 1998
- Manuscript Revised: 1 JUL 1996
- Manuscript Received: 10 JAN 1996
Funded by
- National Institute of Environmental Health Sciences. Grant Number: ES-06290
- Abstract
- References
- Cited By
Keywords:
- 60 Hz magnetic fields;
- DNA single-strand and double-strand breaks;
- brain cells;
- microgel electrophoresis
Abstract
Acute (2 h) exposure of rats to a 60 Hz magnetic field (flux densities 0.1, 0.25, and 0.5 mT) caused a dose-dependent increase in DNA strand breaks in brain cells of the animals (assayed by a microgel electrophoresis method at 4 h postexposure). An increase in single-strand DNA breaks was observed after exposure to magnetic fields of 0.1, 0.25, and 0.5 mT, whereas an increase in double-strand DNA breaks was observed at 0.25 and 0.5 mT. Because DNA strand breaks may affect cellular functions, lead to carcinogenesis and cell death, and be related to onset of neurodegenerative diseases, our data may have important implications for the possible health effects of exposure to 60 Hz magnetic fields. Bioelectromagnetics 18:156–165, 1997. © 1997 Wiley-Liss, Inc.