Carboxyl/cholinesterases: a case study of the evolution of a successful multigene family
Article first published online: 1 DEC 1999
Copyright © 1999 John Wiley & Sons, Inc.
Volume 21, Issue 12, pages 1031–1042, December 1999
How to Cite
Oakeshott, J.G., Claudianos, C., Russell, R.J. and Robin, G.C. (1999), Carboxyl/cholinesterases: a case study of the evolution of a successful multigene family. Bioessays, 21: 1031–1042. doi: 10.1002/(SICI)1521-1878(199912)22:1<1031::AID-BIES7>3.0.CO;2-J
- Issue published online: 1 DEC 1999
- Article first published online: 1 DEC 1999
The evolution of organismal diversity among the Metazoa is dependent on the proliferation of genes and diversification of functions in multigene families. Here we analyse these processes for one highly successful family, the carboxyl/cholinesterases. One key to the expansion of the functional niche of this group of enzymes is associated with versatile substrate binding and catalytic machinery. Qualitatively new functions can be obtained by substitution of one or a very few amino acids. This crudely adapted new functionality is then refined rapidly by a pulse of change elsewhere in the molecule; in one case about 13% amino acid divergence occurred in 5–10 million years. Furthermore, we postulate that the versatility of the substrate binding motifs underpins the recruitment of several family members to additional noncatalytic signal transduction functions. BioEssays 21:1031–1042, 1999. © 1999 John Wiley & Sons, Inc.