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Keywords:

  • Antitumor agents;
  • Cyclophanes;
  • Eleuthesides;
  • Natural products;
  • Total synthesis

Abstract

A ring expansion/ring contraction sequence is one of the key steps in the stereoselective synthesis of the tricyclic eleutheside skeleton 2 from α-phellandrene 1. Eleuthesides are natural products that are isolated from different marine sources, and several of these compounds display taxol-like anticancer activity.