A Convergent Route for the Total Synthesis of the Eleuthesides

Authors

  • Xiao-Tao Chen,

    1. Department of Chemistry, Columbia University, Havemeyer Hall, New York, NY 10027, USA, [+] Other address:, Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10021, USA, Fax: Int. code +(1) 212 772-8691
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  • Clare E. Gutteridge,

    1. Department of Chemistry, Columbia University, Havemeyer Hall, New York, NY 10027, USA, [+] Other address:, Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10021, USA, Fax: Int. code +(1) 212 772-8691
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  • Samit K. Bhattacharya,

    1. Department of Chemistry, Columbia University, Havemeyer Hall, New York, NY 10027, USA, [+] Other address:, Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10021, USA, Fax: Int. code +(1) 212 772-8691
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  • Bishan Zhou,

    1. Department of Chemistry, Columbia University, Havemeyer Hall, New York, NY 10027, USA, [+] Other address:, Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10021, USA, Fax: Int. code +(1) 212 772-8691
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  • Thomas R. R. Pettus,

    1. Department of Chemistry, Columbia University, Havemeyer Hall, New York, NY 10027, USA, [+] Other address:, Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10021, USA, Fax: Int. code +(1) 212 772-8691
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  • Tony Hascall,

    1. Department of Chemistry, Columbia University, Havemeyer Hall, New York, NY 10027, USA, [+] Other address:, Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10021, USA, Fax: Int. code +(1) 212 772-8691
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  • Samuel J. Danishefsky

    1. Department of Chemistry, Columbia University, Havemeyer Hall, New York, NY 10027, USA, [+] Other address:, Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10021, USA, Fax: Int. code +(1) 212 772-8691
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Abstract

A ring expansion/ring contraction sequence is one of the key steps in the stereoselective synthesis of the tricyclic eleutheside skeleton 2 from α-phellandrene 1. Eleuthesides are natural products that are isolated from different marine sources, and several of these compounds display taxol-like anticancer activity.

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