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Communication
Total Syntheses of Vancomycin and Eremomycin Aglycons
Article first published online: 17 DEC 1998
DOI: 10.1002/(SICI)1521-3773(19981016)37:19<2700::AID-ANIE2700>3.0.CO;2-P
© 1998 WILEY-VCH Verlag GmbH, Weinheim, Fed. Rep. of Germany
1521-3773(19981016)37:19<>1.0.CO;2-R/asset/cover.gif?v=1&s=15eec42e7837eaff4c51dc7206e90aba4232adea "Angewandte Chemie International Edition")
Additional Information
How to Cite
Evans, D. A., Wood, M. R., Trotter, B. W., Richardson, T. I., Barrow, J. C. and Katz, J. L. (1998), Total Syntheses of Vancomycin and Eremomycin Aglycons. Angew. Chem. Int. Ed., 37: 2700–2704. doi: 10.1002/(SICI)1521-3773(19981016)37:19<2700::AID-ANIE2700>3.0.CO;2-P
Publication History
- Issue published online: 17 DEC 1998
- Article first published online: 17 DEC 1998
- Manuscript Received: 17 AUG 1998
- Abstract
- Cited By
Keywords:
- Antibiotics;
- Eremomycin;
- Natural products;
- Total synthesis;
- Vancomycin
Abstract
Controlling the elements of planar and axial chirality are the principal challenges in the synthesis of the aglycon of vancomycin. Vancomycin is the prototypical member of the glycopeptide family of antibiotics which are effective for the treatment of infections by methicillin-resistant Staphylococcus aureus. The first total syntheses of the vancomycin and eremomycin aglycons provide insight into the influence of structure on kinetic and thermodynamic control of atropselective macrocyclizations.