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Review
Polyvalent Interactions in Biological Systems: Implications for Design and Use of Multivalent Ligands and Inhibitors
Article first published online: 17 DEC 1998
DOI: 10.1002/(SICI)1521-3773(19981102)37:20<2754::AID-ANIE2754>3.0.CO;2-3
© 1998 WILEY-VCH Verlag GmbH, Weinheim, Fed. Rep. of Germany
1521-3773(19981102)37:20<>1.0.CO;2-2/asset/cover.gif?v=1&s=fab6560d5bb72550cb5ee5e687d34d11a0e215a1 "Angewandte Chemie International Edition")
Additional Information
How to Cite
Mammen, M., Choi, S.-K. and Whitesides, G. M. (1998), Polyvalent Interactions in Biological Systems: Implications for Design and Use of Multivalent Ligands and Inhibitors. Angew. Chem. Int. Ed., 37: 2754–2794. doi: 10.1002/(SICI)1521-3773(19981102)37:20<2754::AID-ANIE2754>3.0.CO;2-3
Publication History
- Issue published online: 17 DEC 1998
- Article first published online: 17 DEC 1998
- Manuscript Received: 14 AUG 1997
- Abstract
- Cited By
Keywords:
- Cooperative effects;
- Molecular recognition;
- Noncovalent interactions;
- Polyvalency;
- Receptors
Abstract
Found throughout biology, polyvalent interactions are characterized by the simultaneous binding of multiple ligands on one biological entity to multiple receptors on another (top part of the illustration) and have a number of characteristics that monovalent interactions do not (bottom). In particular, polyvalent interactions can be collectively much stronger than corresponding monovalent interactions, and they can provide the basis for mechanisms of both agonizing and antagonizing biological interactions that are fundamentally different from those available in monovalent systems.