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Review
The Art and Science of Total Synthesis at the Dawn of the Twenty-First Century
Article first published online: 12 JAN 2000
DOI: 10.1002/(SICI)1521-3773(20000103)39:1<44::AID-ANIE44>3.0.CO;2-L
© 2000 WILEY-VCH Verlag GmbH, Weinheim, Fed. Rep. of Germany
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Additional Information
How to Cite
Nicolaou, K. C., Vourloumis, D., Winssinger, N. and Baran, P. S. (2000), The Art and Science of Total Synthesis at the Dawn of the Twenty-First Century. Angewandte Chemie International Edition, 39: 44–122. doi: 10.1002/(SICI)1521-3773(20000103)39:1<44::AID-ANIE44>3.0.CO;2-L
Publication History
- Issue published online: 12 JAN 2000
- Article first published online: 12 JAN 2000
- Manuscript Received: 10 JUN 1999
- Abstract
- Cited By
Keywords:
- drug research;
- natural products;
- synthetic methods;
- total synthesis
Abstract
A new millenium has begun—grounds enough to question the present state of the total synthesis of natural products. In this review we answer this question by tracing the evolution of this fine art and science from its birth to the present time. This retrospective on total synthesis should serve to demonstrate how far we have come, yet show that the science of total synthesis is still in its infancy.