• 1
    Dinarello, C. A., Biologic basis for interleukin-1 in disease. Blood 1996. 87: 20952147.
  • 2
    Tarlow, J. L., Blakemore, A. I. R., Lennard, A., Solari, R., Hughes, H. N., Steinkasser, A. and Duff, G. W., Polymorphism in human IL-1 receptor antagonist gene intron 2 is caused by variable numbers of an 86-bp tandem repeat. Hum. Genet. 1993. 91: 403404.
  • 3
    Mansfield, J. C., Holden, H., Tarlow, J. K., di Giovine, F. S., McDowell, T. L., Wilson, A. G., Holdsworth, C. D. and Duff, G. W., Novel genetic association between ulcerative colitis and the anti-inflammatory cytokine interleukin-1 receptor antagonist. Gastroenterology 1994. 106: 637642.
  • 4
    Crusius, J. B. A., Pena, A. S., van Oosten, B. W., Bioque, G., Garcia, A., Dijkstra, C. D. and Polman, C. H., Interleukin-1 receptor antagonist gene polymorphism and multiple sclerosis. Lancet 1995. 346: 979980.
  • 5
    Tarlow, J. K., Clay, R. E., Cork, M. J., Blakemore, A. I. F., McDonagh, A. J. G., Messenger, A. G. and Duff, G. W., Severity of alopecia areata is associated with polymorphism in the interleukin-1 receptor antagonist gene. J. Invest. Dermatol. 1994. 103: 387390.
  • 6
    Blakemore, A. I. R., Cox, A., Gonzales, A.-M., Maskill, J. K., Hughes, M. E., Wilson, R. M., Ward, J. D. and Duff, G. W., Interleukin-1 receptor antagonist allele (IL1 RN*2) associated with nephropathy in diabetes mellitus. Hum. Genet. 1996. 97: 369374.
  • 7
    Blakemore, A. I. F., Watson, P. F., Weetman, A. P. and Duff, G. W., Association of Graves' disease with an allele of the interleukin-1 receptor antagonist gene. J. Clin. Endocrinol. Metab. 1995. 80: 111115.
  • 8
    Danis, V. A., Millington, M., Hyland, V. J. and Grennan, D., Cytokine production by normal human monocytes: inter-subject variation and relationship to an IL-1 receptor antagonist (IL-1Ra) gene polymorphism. Clin. Exp. Immunol. 1995. 99: 303310.
  • 9
    Mandrup-Poulsen, T., Pociot, F., Molvig, J., Shapiro, L., Nilsson, P., Emdal, T., Roder, M., Kjems, L. L., Dinarello, C. A. and Nerup, J., Monokine antagonism is reduced in patients with IDDM. Diabetes 1994. 43: 12421247.
  • 10
    Di Giovine, F. S., Takhsh, E., Blakemore, A. I. F. and Duff, G. W., Single base polymorphism at −511 in the human interleukin-1β gene. Hum. Mol. Genet. 1992. 1: 450451.
  • 11
    Pociot, F., Molvig, J., Wogensen, L., Worsaae, H. and Nerup, J., A Taql polymorphism in the human interleukin-1β (IL-1β gene correlates with IL-1β secretion in vitro. Eur. J. Clin. Invest. 1992. 22: 396402.
  • 12
    Bioque, G., Crusius, J. B. A., Koutroubakis, I., Bouma, G., Kostense, P. J., Meuwissen, S. G. M. and Pena, A. S., Allelic polymorphism in IL-1β and IL-1 receptor antagonist (IL-1Ra) genes in inflammatory bowel diseases. Clin. Exp. Immunol. 1995. 102: 379383.
  • 13
    Tilg, H., Trehu, E., Shapiro, L., Pape, D., Atkins, M. B., Dinarello, C. A. and Mier, J. W., Induction of circulating soluble tumor necrosis factor receptor and interleukin-1 receptor antagonist following interleukin 1α infusion in humans. Cytokine 1994. 6: 215219.
  • 14
    Santtila, S., Savinainen, K. and Hurme, M., Presence of the IL-1RA allele 2 (IL1RN*2) is associated with enhanced IL-1β production in vitro. Scand. J. Immunol. 1998. 47: 195198.
  • 15
    Miller, S. A., Dykes, D. D. and Polesky, H. F., A simple salting out procedure fir extracting DNA from human nucleated cells. Nucleic Acids Res. 1988. 16: 1215.