Communication

Utilizing hemodynamic delay and dispersion to detect fMRI signal change without auditory interference: The behavior interleaved gradients technique

  1. G.F. Eden1,*,
  2. J.E. Joseph1,
  3. H.E. Brown1,
  4. C.P. Brown1,
  5. T.A. Zeffiro1,2

Article first published online: 29 JAN 1999

DOI: 10.1002/(SICI)1522-2594(199901)41:1<13::AID-MRM4>3.0.CO;2-T

Issue

Magnetic Resonance in Medicine

Magnetic Resonance in Medicine

Volume 41, Issue 1, pages 13–20, January 1999

Additional Information

How to Cite

Eden, G., Joseph, J., Brown, H., Brown, C. and Zeffiro, T. (1999), Utilizing hemodynamic delay and dispersion to detect fMRI signal change without auditory interference: The behavior interleaved gradients technique. Magnetic Resonance in Medicine, 41: 13–20. doi: 10.1002/(SICI)1522-2594(199901)41:1<13::AID-MRM4>3.0.CO;2-T

Author Information

  1. 1

    Georgetown Institute for Cognitive and Computational Sciences, Georgetown University Medical Center, Washington DC 20007.

  2. 2

    Sensor Systems, Sterling, Virginia.

*Georgetown University Medical Center, Washington, DC 20007.

Publication History

  1. Issue published online: 29 JAN 1999
  2. Article first published online: 29 JAN 1999
  3. Manuscript Accepted: 8 SEP 1998
  4. Manuscript Revised: 27 AUG 1998
  5. Manuscript Received: 6 APR 1998

Funded by

  • Charles A. Dana Foundation
  • Department of Defense. Grant Number: DAMD17–93-V-3018

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Keywords:

  • neuroimaging;
  • motor cortex;
  • auditory;
  • behavior interleaved gradients;
  • single-trial fMRI

Abstract

A major problem associated with the use of functional magnetic resonance imaging (fMRI) is the attendant gradient noise, which causes undesirable auditory system stimulation. A method is presented here that delays data acquisition to a period immediately after task completion, utilizing the physiological delay and dispersion between neuronal activity and its resulting hemodynamic lag. Subjects performed finger movements with the gradients off, followed by a rest period with the gradients on. This resulted in task-related signals comparable to those obtained with concurrent task performance and image data acquisition. This behavior interleaved gradients technique may be particularly useful for the studies involving auditory stimulation or overt verbal responses. Magn Reson Med 41:13-20, 1999. © 1999 Wiley-Liss, Inc.

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