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Full Paper
Non-invasive assessment of axonal fiber connectivity in the human brain via diffusion tensor MRI
Article first published online: 8 JUL 1999
DOI: 10.1002/(SICI)1522-2594(199907)42:1<37::AID-MRM7>3.0.CO;2-O
Copyright © 1999 Wiley-Liss, Inc.
1522-2594/asset/cover.gif?v=1&s=9512352d4133369aa19bc75e4ffa8001ea23b2d9 "Magnetic Resonance in Medicine")
Additional Information
How to Cite
Jones, D. K., Simmons, A., Williams, S. C.R. and Horsfield, M. A. (1999), Non-invasive assessment of axonal fiber connectivity in the human brain via diffusion tensor MRI. Magn. Reson. Med., 42: 37–41. doi: 10.1002/(SICI)1522-2594(199907)42:1<37::AID-MRM7>3.0.CO;2-O
Publication History
- Issue published online: 8 JUL 1999
- Article first published online: 8 JUL 1999
- Manuscript Accepted: 18 MAR 1999
- Manuscript Revised: 31 JAN 1999
- Manuscript Received: 29 JUL 1998
Funded by
- Wellcome Trust. Grant Number: 04235/Z/94/Z
- SmithKline Beecham Pharmaceuticals PLC
- Abstract
- References
- Cited By
Keywords:
- diffusion tensor;
- diffusion anisotropy;
- connectivity;
- magnetic resonance imaging
Abstract
A technique for assessing in vivo fiber connectivity in the human brain is presented. The method utilizes a novel connectivity algorithm that operates in three spatial dimensions and uses estimates of fiber tract orientation and tissue anisotropy, obtained from diffusion tensor magnetic resonance imaging, to establish the pathways of fiber tracts. Sample in vivo connectivity images from healthy human brain are presented that demonstrate connections in the white matter tracts. White matter connectivity information is potentially of interest in the study of a range of neurological, psychiatric, and developmental disorders and shows promise for following the natural history of disease. Magn Reson Med 42:37–41, 1999. © 1999 Wiley-Liss, Inc.